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5-HT5B receptor

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HTR5BP
Identifiers
AliasesHTR5BP, 5-HT5B, GPR134, HTR5B, 5-hydroxytryptamine receptor 5B, pseudogene
External IDsMGI: 96284; GeneCards: HTR5BP; OMA:HTR5BP - orthologs
Orthologs
SpeciesHumanMouse
Entrez

645694

15564

Ensembl

ENSG00000125631

ENSMUSG00000050534

UniProt

n
a

P31387

RefSeq (mRNA)

n/a

NM_010483

RefSeq (protein)

n/a

NP_034613

Location (UCSC)n/aChr 1: 121.44 – 121.46 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

5-HT5B receptor is a 5-HT receptor protein and the gene which encodes it. The protein is found in rodents, but not in humans, because stop codons in the gene's coding sequence prevent the gene from expressing a functional protein.[4] It is believed that the function of the 5-HT5B receptor has been replaced in humans by some other subclass of 5-HT receptor.[5] 5-HT5B receptor is a G protein-coupled receptor.[6] 5-HT5B receptor mRNA is expressed primarily in the habenula, hippocampus and inferior olive of rat brains.[7] Known agonists for 5-HT5B include ergotamine and LSD. Known antagonists include methiothepin.

References

[edit]
  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050534 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Grailhe, R; Grabtree, GW; Hen, R (2001-04-27). "Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution". European Journal of Pharmacology. 418 (3): 157–67. doi:10.1016/S0014-2999(01)00933-5. PMID 11343685.
  5. ^ Roth, Bryan L., ed. (2006). The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics. The receptors (1st ed.). Humana Press. p. 25. ISBN 978-1-58829-568-2. Retrieved 2009-11-08.
  6. ^ Wisden, William; Parker, Eric M.; Mahle, Cathy D.; Grisel, Darcy A.; Nowak, Henry P.; Yocca, Frank D.; Felder, Christian C.; Seeburg, Peter H.; Voigt, Mark M. (1993-10-25). "Cloning and characterization of the rat 5-HT5B receptor: Evidence that the 5-HT5B receptor couples to a G protein in mammalian cell membranes". FEBS Letters. 333 (1): 25–31. doi:10.1016/0014-5793(93)80368-5. PMID 8224165. S2CID 46535116.
  7. ^ Kinsey, AM; Wainwright, A; Heavens, R; Sirinathsinghji, DJ; Oliver, KR (2001-03-31). "Distribution of 5-ht(5A), 5-ht(5B), 5-ht(6) and 5-HT(7) receptor mRNAs in the rat brain". Molecular Brain Research. 88 (1–2): 194–8. doi:10.1016/S0169-328X(01)00034-1. PMID 11295248.


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