F-11,461

F-11,461
Identifiers
	IUPAC name 2-[4-[4-[7-(Methoxy-11C)-1-naphthalenyl]-1-piperazinyl]butyl]-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione;
CAS Number	874471-25-7 ;
PubChem CID	10324985;
ChemSpider	9850903 ;
UNII	RKG24J8KJR;
ChEMBL	ChEMBL199824;
Chemical and physical data
Formula	C23H29N5O3
Molar mass	423.517 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1C=NN(C(=O)N1C)CCCCN2CCN(C3=CC=CC4=CC=C(O[11C])C=C43)CC2;
	InChI InChI=InChI=1S/C23H29N5O3/c1-25-22(29)17-24-28(23(25)30)11-4-3-10-26-12-14-27(15-13-26)21-7-5-6-18-8-9-19(31-2)16-20(18)21/h5-9,16-17H,3-4,10-15H2,1-2H3/i2-1; Key:GKTQBPYMIGXPKG-JVVVGQRLSA-N;

F-11,461 is a drug that acts as an agonist of the 5-HT_1A receptor (K_i = 1.36 nM) that has been used as a radioligand in PET studies. It possesses modest affinity for the 5-HT₇ (K_i = 9.1 nM) and D₄ (K_i = 8.5 nM) receptors, although the interaction of F-11,461 with these receptors is not detectable with PET due to their relative scarcity in the brain.^[1]

References

^ Kumar JS, Majo VJ, Hsiung SC, Millak MS, Liu KP, Tamir H, et al. (January 2006). "Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand". Journal of Medicinal Chemistry. 49 (1): 125–134. doi:10.1021/jm050725j. PMID 16392798.

[1] Kumar JS, Majo VJ, Hsiung SC, Millak MS, Liu KP, Tamir H, et al. (January 2006). "Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand". Journal of Medicinal Chemistry. 49 (1): 125–134. doi:10.1021/jm050725j. PMID 16392798.

[1]

See also

References