LY-367642

LY-367642
Identifiers
	IUPAC name 1-[2-[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl]-3-pyridin-4-yl-methyl-tetrahydro-pyrimidin-2-one;
CAS Number	721417-29-4;
PubChem CID	90710983;
CompTox Dashboard (EPA)	DTXSID001336905 ;
Chemical and physical data
Formula	C25H28FN5O
Molar mass	433.531 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(N(CC1=CC=NC=C1)CCC2)N2CCN3CCC(C4=CNC5=CC(F)=CC=C54)=CC3;
	InChI InChI=1S/C25H28FN5O/c26-21-2-3-22-23(17-28-24(22)16-21)20-6-12-29(13-7-20)14-15-30-10-1-11-31(25(30)32)18-19-4-8-27-9-5-19/h2-6,8-9,16-17,28H,1,7,10-15,18H2; Key:BMJOWGWDSXFWQE-UHFFFAOYSA-N;

LY-367642 is a potent and selective serotonin 5-HT_1D receptor antagonist which has been used in research to study the function of presynaptic 5-HT_1D autoreceptors.^[1]

References

^ Pullar IA, Boot JR, Broadmore RJ, Eyre TA, Cooper J, Sanger GJ, Wedley S, Mitchell SN (June 2004). "The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig". European Journal of Pharmacology. 493 (1–3): 85–93. doi:10.1016/j.ejphar.2004.04.029. PMID 15189767.

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