UH-301

UH-301
Identifiers
	IUPAC name (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin;
CAS Number	127126-22-1 ;
IUPHAR/BPS	61;
UNII	1T7773JH5N;
CompTox Dashboard (EPA)	DTXSID70155410 ;
Chemical and physical data
Formula	C16H24FNO
Molar mass	265.372 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C2Cc1c(c(O)ccc1F)CC2N(CCC)CCC;
	(verify)

(S)-UH-301 is a drug and research chemical widely used in scientific studies. It acts as a selective 5-HT_1A receptor silent antagonist.^[1] It is structurally related to 8-OH-DPAT.^[1] UH-301 was found to produce a head-twitch response in mice which is usually typical of 5-HT_2A agonist drugs, and has subsequently been used to investigate how 5-HT_1A receptor activity modulates 5-HT_2A receptors downstream.^[2]

References

^ ^a ^b Björk L, Cornfield LJ, Nelson DL, Hillver SE, Andén NE, Lewander T, Hacksell U (July 1991). "Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects". The Journal of Pharmacology and Experimental Therapeutics. 258 (1): 58–65. PMID 1830099.
^ Darmani NA, Reeves SL (September 1996). "The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice". Pharmacology, Biochemistry, and Behavior. 55 (1): 1–10. doi:10.1016/0091-3057(96)00072-X. PMID 8870031. S2CID 25607128.

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[pmid1830099-1] Björk L, Cornfield LJ, Nelson DL, Hillver SE, Andén NE, Lewander T, Hacksell U (July 1991). "Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects". The Journal of Pharmacology and Experimental Therapeutics. 258 (1): 58–65. PMID 1830099.

[2] Darmani NA, Reeves SL (September 1996). "The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice". Pharmacology, Biochemistry, and Behavior. 55 (1): 1–10. doi:10.1016/0091-3057(96)00072-X. PMID 8870031. S2CID 25607128.

[1]

[2]

See also

References