Tertatolol

Tertatolol
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	C07AA16 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name (±)-1-(tert-Butylamino)-3-(3,4-dihydro-2H-thiochromen-8-yloxy)propan-2-ol;
CAS Number	83688-84-0 ;
PubChem CID	36920;
IUPHAR/BPS	571;
ChemSpider	33875 ;
UNII	9ZO341YQXP;
KEGG	D07182 ;
ChEMBL	ChEMBL434200 ;
CompTox Dashboard (EPA)	DTXSID80865735 ;
ECHA InfoCard	100.073.179
Chemical and physical data
Formula	C16H25NO2S
Molar mass	295.44 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES CC(C)(C)NCC(COC1=CC=CC2=C1SCCC2)O;
	InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 ; Key:HTWFXPCUFWKXOP-UHFFFAOYSA-N ;
	(what is this?) (verify)

Tertatolol (Artex, Artexal, Prenalex) is a medication in the class of beta blockers, used in the treatment of high blood pressure. It was discovered by the French pharmaceutical company Servier and is marketed in Europe.^[1]

Tertatolol has also been shown to act as a serotonin 5-HT_1A and 5-HT_1B receptor antagonist, similarly to propranolol and pindolol.^[2]^[3]^[4]

References

^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
^ Langlois M, Brémont B, Rousselle D, Gaudy F (January 1993). "Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors". European Journal of Pharmacology. 244 (1): 77–87. doi:10.1016/0922-4106(93)90061-d. PMID 8093601.
^ Jolas T, Haj-Dahmane S, Lanfumey L, Fattaccini CM, Kidd EJ, Adrien J, et al. (May 1993). "(-)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain". Naunyn-Schmiedeberg's Archives of Pharmacology. 347 (5): 453–463. doi:10.1007/bf00166735. PMID 7686633. S2CID 22129922.
^ van Wijngaarden I, Soudijn W, Tulp MT (1997). "5-HT_1A Receptors". In Soudijn W, Olivier B, van Wijngaarden I (eds.). Serotonin Receptors and Their Ligands. Amsterdam: Elsevier. ISBN 0-444-82041-8.

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[isbn3-88763-075-0-1] Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.

[pmid8093601-2] Langlois M, Brémont B, Rousselle D, Gaudy F (January 1993). "Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors". European Journal of Pharmacology. 244 (1): 77–87. doi:10.1016/0922-4106(93)90061-d. PMID 8093601.

[pmid7686633-3] Jolas T, Haj-Dahmane S, Lanfumey L, Fattaccini CM, Kidd EJ, Adrien J, et al. (May 1993). "(-)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain". Naunyn-Schmiedeberg's Archives of Pharmacology. 347 (5): 453–463. doi:10.1007/bf00166735. PMID 7686633. S2CID 22129922.

[isbn0-444-82041-8-4] van Wijngaarden I, Soudijn W, Tulp MT (1997). "5-HT_1A Receptors". In Soudijn W, Olivier B, van Wijngaarden I (eds.). Serotonin Receptors and Their Ligands. Amsterdam: Elsevier. ISBN 0-444-82041-8.

[1]

[2]

[3]

[4]

v t e Beta blockers (C07)
β, non-selective	Alprenolol Bopindolol Bupranolol Carteolol Cloranolol Mepindolol Nadolol Oxprenolol Penbutolol Pindolol/Iodopindolol Propranolol^# Sotalol Tertatolol Timolol^#
β₁-selective	Acebutolol Atenolol Betaxolol Bevantolol Bisoprolol^# Celiprolol Epanolol Esmolol Landiolol Metoprolol Nebivolol Practolol Talinolol
β₂-selective	Butaxamine
α₁- + β-selective	Arotinolol Carvedilol Labetalol
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

See also

References