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Amidephrine

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Amidephrine
Clinical data
Trade namesDricol, Fentrinol, Nalde
Other namesAmidefrine; MJ-1996; MJ-5190; 3-Methylsulfonamidyl-β-hydroxy-N-methylphenethylamine; 3-Methylsulfonamidyl-β-hydroxy-N-methyl-β-phenylethylamine
ATC code
  • None
Identifiers
  • (RS)-N-{3-[1-hydroxy-2-(methylamino)ethyl]phenyl}methanesulfonamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC10H16N2O3S
Molar mass244.31 g·mol−1
3D model (JSmol)
  • O=S(=O)(Nc1cc(ccc1)C(O)CNC)C
  • InChI=1S/C10H16N2O3S/c1-11-7-10(13)8-4-3-5-9(6-8)12-16(2,14)15/h3-6,10-13H,7H2,1-2H3 checkY
  • Key:ZHOWHMXTJFZXRB-UHFFFAOYSA-N checkY
  (verify)

Amidephrine (BANTooltip British Approved Name), or amidefrine, sold under the brand name Fentrinol among others, is a selective α1-adrenergic receptor agonist which is described as an adrenergic or sympathomimetic, vasoconstrictor, and topical nasal decongestant used to treat allergic rhinitis.[1][2][3][4][5] It is used as the mesylate salt, which has the generic names amidefrine mesilate (INNTooltip International Nonproprietary Name) and amidephrine mesylate (USANTooltip United States Adopted Name).[2] The drug is a substituted phenethylamine derivative and is also known as 3-methylsulfonamidyl-β-hydroxy-N-methylphenethylamine.[2][1][6] As of 2000, it remained marketed only in Austria.[3]

References

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  1. ^ a b Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 40. ISBN 978-1-4757-2085-3. Retrieved 2024-08-31.
  2. ^ a b c Morton IK, Hall JM (2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Netherlands. p. 13. ISBN 978-94-011-4439-1. Retrieved 2024-08-31.
  3. ^ a b Schweizerischer Apotheker-Verein (2000). Index Nominum 2000: International Drug Directory. Medpharm Scientific Publishers. p. 39. ISBN 978-3-88763-075-1. Retrieved 2024-08-31.
  4. ^ "Amidephrine: Uses, Interactions, Mechanism of Action". DrugBank Online. 24 February 2021. Retrieved 31 August 2024.
  5. ^ MacLean MR, Thomson M, Hiley CR (June 1989). "Pressor effects of the alpha 2-adrenoceptor agonist B-HT 933 in anaesthetized and haemorrhagic rats: comparison with the haemodynamic effects of amidephrine". British Journal of Pharmacology. 97 (2): 419–432. doi:10.1111/j.1476-5381.1989.tb11969.x. PMC 1854522. PMID 2569342.
  6. ^ "Amidephrine". PubChem. U.S. National Library of Medicine. Retrieved 31 August 2024.
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