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Protein-coding gene in the species Homo sapiens
Lysophosphatidic acid receptor 2 also known as LPA2 is a protein that in humans is encoded by the LPAR2 gene .[ 5] [ 6] [ 7] 2 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[ 8]
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.[ 5]
LPAR2 has been shown to interact with TRIP6 .[ 9]
Source:[ 10] [ 11]
^ a b c GRCh38: Ensembl release 89: ENSG00000064547 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031861 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2" .^ An S, Bleu T, Hallmark OG, Goetzl EJ (April 1998). "Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid" . J. Biol. Chem . 273 (14): 7906–10. doi :10.1074/jbc.273.14.7906 PMID 9525886 . ^ An S, Bleu T, Zheng Y, Goetzl EJ (November 1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol . 54 (5): 881–8. doi :10.1124/mol.54.5.881 . PMID 9804623 . S2CID 37327084 . ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology . 50 (1): 157–186. doi :10.1146/annurev.pharmtox.010909.105753 . PMID 20055701 . ^ Xu J, Lai Yun-Ju, Lin Weei-Chin, Lin Fang-Tsyr (March 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor" . J. Biol. Chem . 279 (11). United States: 10459–68. doi :10.1074/jbc.M311891200 ISSN 0021-9258 . PMC 3904432 PMID 14688263 . ^ "GeneCards®: The Human Gene Database" .^ "Ensembl Genome Browser" .
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .
