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GNRHR

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GNRHR
Identifiers
AliasesGNRHR, GNRHR1, GRHR, HH7, LHRHR, LRHR, gonadotropin releasing hormone receptor
External IDsOMIM: 138850; MGI: 95790; HomoloGene: 350; GeneCards: GNRHR; OMA:GNRHR - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001012763
NM_000406

NM_010323
NM_001310651
NM_001310653

RefSeq (protein)

NP_000397
NP_001012781

NP_001297580
NP_001297582
NP_034453

Location (UCSC)Chr 4: 67.74 – 67.75 MbChr 5: 86.33 – 86.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gonadotropin-releasing hormone receptor is a protein that in humans is encoded by the GNRHR gene.[5][6]

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109163Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029255Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chi L, Zhou W, Prikhozhan A, Flanagan C, Davidson JS, Golembo M, Illing N, Millar RP, Sealfon SC (May 1993). "Cloning and characterization of the human GnRH receptor". Mol Cell Endocrinol. 91 (1–2): R1–6. doi:10.1016/0303-7207(93)90278-R. PMID 8386108. S2CID 22807298.
  6. ^ a b "Entrez Gene: GNRHR gonadotropin-releasing hormone receptor".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.