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Neurotensin receptor 2

From Wikipedia, the free encyclopedia

NTSR2
Identifiers
AliasesNTSR2, NTR2, Neurotensin receptor 2
External IDsOMIM: 605538; MGI: 108018; HomoloGene: 7452; GeneCards: NTSR2; OMA:NTSR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012344

NM_008747
NM_001361702
NM_001361703

RefSeq (protein)

NP_036476

NP_032773
NP_001348631
NP_001348632

Location (UCSC)Chr 2: 11.66 – 11.67 MbChr 12: 16.7 – 16.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.[5][6][7]

Function

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The protein encoded by this gene belongs to the G protein-coupled receptor family that activates a phosphatidylinositol-calcium second messenger system.[7] Binding and pharmacological studies demonstrate that this receptor binds Neurotensin (NT) as well as several other ligands already described for Neurotensin receptor 1. NT function is known to be a neuromodulator of dopamine and has hypothermic and analgesic properties in the brain and some peripheral organ function as well.[8] NTS2 is found mostly in the brain through Northern-blot analysis.[8]Unlike NTS1, NTS2 has a low affinity with NT and a high sensitivity to levocabastine, an antihistamine, which competes with NT for binding.[8]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169006Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020591Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, et al. (May 1996). "Molecular cloning of a levocabastine-sensitive neurotensin binding site". FEBS Letters. 386 (2–3): 91–94. doi:10.1016/0014-5793(96)00397-3. PMID 8647296. S2CID 5802578.
  6. ^ Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, et al. (November 1998). "Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells". European Journal of Pharmacology. 360 (2–3): 265–272. doi:10.1016/S0014-2999(98)00678-5. PMID 9851594.
  7. ^ a b "NTSR2 neurotensin receptor 2". Entrez Gene. U.S. National Library of Medicine.
  8. ^ a b c Vincent JP, Mazella J, Kitabgi P (July 1999). "Neurotensin and neurotensin receptors". Trends in Pharmacological Sciences. 20 (7): 302–309. doi:10.1016/s0165-6147(99)01357-7. PMID 10390649.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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