Frizzled-9

FZD9
Identifiers
Aliases	FZD9, CD349, FZD3, frizzled class receptor 9
External IDs	OMIM: 601766; MGI: 1313278; HomoloGene: 2619; GeneCards: FZD9; OMA:FZD9 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	73,436,120 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,280,084 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; muscle of thigh; ; gastrocnemius muscle; ; amygdala; ; cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; C1 segment; ; hypothalamus; ; right frontal lobe;
	Top expressed in
	rib; ; myotome; ; soleus muscle; ; lumbar subsegment of spinal cord; ; lumbar spine; ; ventricular zone; ; stria vascularis; ; plantaris muscle; ; larynx; ; extensor digitorum longus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; signal transducer activity; Wnt-protein binding; protein heterodimerization activity; transmembrane signaling receptor activity; G protein-coupled receptor activity; Wnt-activated receptor activity;
Cellular component	cytoplasm; membrane; plasma membrane; cell surface; perinuclear region of cytoplasm; filopodium membrane; endoplasmic reticulum membrane; Golgi apparatus; mitochondrial membranes; integral component of membrane; postsynapse; glutamatergic synapse;
Biological process	G protein-coupled receptor signaling pathway; Wnt signaling pathway; nervous system development; multicellular organism development; cell surface receptor signaling pathway; learning or memory; neuroblast proliferation; B cell differentiation; signal transduction; ossification; release of cytochrome c from mitochondria; positive regulation of bone mineralization; positive regulation of apoptotic process; negative regulation of neuron apoptotic process; regulation of cytosolic calcium ion concentration; negative regulation of mitochondrial depolarization; negative regulation of necroptotic process; positive regulation of canonical Wnt signaling pathway; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; regulation of skeletal muscle acetylcholine-gated channel clustering; negative regulation of skeletal muscle acetylcholine-gated channel clustering; bone regeneration; positive regulation of neural precursor cell proliferation; non-canonical Wnt signaling pathway; canonical Wnt signaling pathway; postsynapse organization; regulation of postsynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	8326
	14371
	ENSG00000188763
	ENSMUSG00000049551
	O00144
	Q9R216
	NM_003508
	NM_010246
	NP_003499
	NP_034376
	Wikidata
View/Edit Human	View/Edit Mouse

Frizzled-9 (Fz-9) is a protein that in humans is encoded by the FZD9 gene.^[5]^[6]^[7] Fz-9 has also been designated as CD349 (cluster of differentiation 349).

Function

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188763 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049551 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang YK, Samos CH, Peoples R, Pérez-Jurado LA, Nusse R, Francke U (Mar 1997). "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23". Human Molecular Genetics. 6 (3): 465–72. doi:10.1093/hmg/6.3.465. PMID 9147651.
^ Wang YK, Spörle R, Paperna T, Schughart K, Francke U (Apr 1999). "Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome". Genomics. 57 (2): 235–48. doi:10.1006/geno.1999.5773. PMID 10198163.
^ ^a ^b "Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)".

External links

"Frizzled Receptors: FZD₉". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2012-03-19. Retrieved 2008-12-04.
FZD9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000188763 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049551 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9147651-5] Wang YK, Samos CH, Peoples R, Pérez-Jurado LA, Nusse R, Francke U (Mar 1997). "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23". Human Molecular Genetics. 6 (3): 465–72. doi:10.1093/hmg/6.3.465. PMID 9147651.

[pmid10198163-6] Wang YK, Spörle R, Paperna T, Schughart K, Francke U (Apr 1999). "Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome". Genomics. 57 (2): 235–48. doi:10.1006/geno.1999.5773. PMID 10198163.

[entrez-7] "Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)".

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Function

References

Further reading

External links