IGSF2

CD101
Identifiers
Aliases	CD101, EWI-101, IGSF2, V7, CD101 molecule
External IDs	OMIM: 604516; MGI: 2685862; HomoloGene: 3142; GeneCards: CD101; OMA:CD101 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	117,036,552 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	100,936,872 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; testicle; ; right lung; ; mucosa of transverse colon; ; bone marrow cells; ; ventricular zone; ; upper lobe of left lung; ; blood; ; rectum;
	Top expressed in
	granulocyte; ; morula; ; jejunum; ; duodenum; ; muscle of thigh; ; bone marrow; ; ileum; ; lung; ; colon; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;
Cellular component	plasma membrane; extracellular exosome; membrane; integral component of membrane;
Biological process	cell surface receptor signaling pathway; positive regulation of myeloid leukocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	9398
	630146
	ENSG00000134256
	ENSMUSG00000086564
	Q93033
	A8E0Y8
	NM_001256106; NM_001256109; NM_001256111; NM_004258
	NM_001099332; NM_001167906
	NP_001243035; NP_001243038; NP_001243040; NP_004249
	NP_001161378
	Wikidata
View/Edit Human	View/Edit Mouse

Immunoglobulin superfamily, member 2 (IGSF2) also known as CD101 (Cluster of Differentiation 101), is a human gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134256 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000086564 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IGSF2 immunoglobulin superfamily, member 2".

Rivas A, Ruegg CL, Zeitung J, et al. (1995). "V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies". J. Immunol. 154 (9): 4423–33. doi:10.4049/jimmunol.154.9.4423. PMID 7722299.
Ruegg CL, Rivas A, Madani ND, et al. (1995). "V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene". J. Immunol. 154 (9): 4434–43. doi:10.4049/jimmunol.154.9.4434. PMID 7722300. S2CID 22225700.
Soares LR, Rivas A, Tsavaler L, Engleman EG (1997). "Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism". J. Immunol. 159 (3): 1115–24. doi:10.4049/jimmunol.159.3.1115. PMID 9233604. S2CID 32846335.
Bagot M, Martinel I, Charue D, et al. (1998). "CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation". Tissue Antigens. 50 (5): 439–48. doi:10.1111/j.1399-0039.1997.tb02898.x. PMID 9389317.
Soares LR, Tsavaler L, Rivas A, Engleman EG (1998). "V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation". J. Immunol. 161 (1): 209–17. doi:10.4049/jimmunol.161.1.209. PMID 9647226. S2CID 24815632.
Bouloc A, Boulland ML, Geissmann F, et al. (2000). "CD101 expression by Langerhans cell histiocytosis cells". Histopathology. 36 (3): 229–32. doi:10.1046/j.1365-2559.2000.00827.x. PMID 10692025. S2CID 36983914.
Bouloc A, Bagot M, Delaire S, et al. (2001). "Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL-10 production". Eur. J. Immunol. 30 (11): 3132–9. doi:10.1002/1521-4141(200011)30:11<3132::AID-IMMU3132>3.0.CO;2-E. PMID 11093127. S2CID 45350340.
Stipp CS, Kolesnikova TV, Hemler ME (2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J. Biol. Chem. 276 (44): 40545–54. doi:10.1074/jbc.M107338200. PMID 11504738.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Meyer N, Petrella T, Poszepczynska-Guigne E, et al. (2005). "CD4+ CD56+ blastic tumor cells express CD101 molecules". J. Invest. Dermatol. 124 (3): 668–9. doi:10.1111/j.0022-202X.2005.23617.x. PMID 15737213.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

IGSF2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134256 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000086564 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IGSF2 immunoglobulin superfamily, member 2".

[1]

[2]

[3]

[4]

[5]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

IGSF2

See also

References

Further reading

External links