Decoy receptor 2

TNFRSF10D
Identifiers
Aliases	TNFRSF10D, CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD, tumor necrosis factor receptor superfamily member 10d, TNF receptor superfamily member 10d
External IDs	OMIM: 603614; HomoloGene: 136778; GeneCards: TNFRSF10D; OMA:TNFRSF10D - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	23,164,027 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; pancreatic epithelial cell; ; stromal cell of endometrium; ; pancreatic ductal cell; ; islet of Langerhans; ; mucosa of ileum; ; right lobe of liver; ; endothelial cell; ; gastric mucosa; ; monocyte;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane signaling receptor activity; tumor necrosis factor-activated receptor activity; TRAIL binding;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; cell surface;
Biological process	multicellular organism development; response to lipopolysaccharide; inflammatory response; negative regulation of apoptotic process; regulation of cell population proliferation; immune response; signal transduction; apoptotic process; tumor necrosis factor-mediated signaling pathway; regulation of apoptotic process; leukocyte migration; apoptotic signaling pathway; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cell surface receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8793
	n/a
	ENSG00000173530
	n/a
	Q9UBN6
	n/a
	NM_003840
	n/a
	NP_003831
	n/a
	Wikidata
View/Edit Human

Decoy receptor 2 (DCR2), also known as TRAIL receptor 4 (TRAILR4) and tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), is a human cell surface receptor of the TNF-receptor superfamily.^[3]^[4]^[5]

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain.

This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173530 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenazi A (Feb 1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain". Curr Biol. 7 (12): 1003–6. Bibcode:1997CBio....7.1003M. doi:10.1016/S0960-9822(06)00422-2. PMID 9382840. S2CID 21645158.
^ Pan G, Ni J, Yu G, Wei YF, Dixit VM (Apr 1998). "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling" (PDF). FEBS Lett. 424 (1–2): 41–5. doi:10.1016/S0014-5793(98)00135-5. PMID 9537512. S2CID 2964615.
^ ^a ^b "Entrez Gene: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain".

Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors". Cell Res. 14 (5): 359–72. doi:10.1038/sj.cr.7290236. PMID 15538968.
Degli-Esposti MA, Dougall WC, Smolak PJ, et al. (1998). "The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain". Immunity. 7 (6): 813–20. doi:10.1016/S1074-7613(00)80399-4. PMID 9430226.
Phillips TA, Ni J, Pan G, et al. (1999). "TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications for immune privilege". J. Immunol. 162 (10): 6053–9. doi:10.4049/jimmunol.162.10.6053. PMID 10229846.
Zhang XD, Franco AV, Nguyen T, et al. (2000). "Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells". J. Immunol. 164 (8): 3961–70. doi:10.4049/jimmunol.164.8.3961. PMID 10754286.
Daigle I, Simon HU (2001). "Alternative functions for TRAIL receptors in eosinophils and neutrophils". Swiss Medical Weekly. 131 (17–18): 231–7. doi:10.4414/smw.2001.09707. PMID 11420819.
Dörr J, Bechmann I, Waiczies S, et al. (2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain". J. Neurosci. 22 (4): RC209. doi:10.1523/JNEUROSCI.22-04-j0001.2002. PMC 6757573. PMID 11844843.
Sun SY, Yue P, Chen X, et al. (2002). "The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells". Cancer Res. 62 (8): 2430–6. PMID 11956107.
Matysiak M, Jurewicz A, Jaskolski D, Selmaj K (2002). "TRAIL induces death of human oligodendrocytes isolated from adult brain". Brain. 125 (Pt 11): 2469–80. doi:10.1093/brain/awf254. PMID 12390973.
Robertson NM, Zangrilli JG, Steplewski A, et al. (2003). "Differential expression of TRAIL and TRAIL receptors in allergic asthmatics following segmental antigen challenge: evidence for a role of TRAIL in eosinophil survival". J. Immunol. 169 (10): 5986–96. doi:10.4049/jimmunol.169.10.5986. PMID 12421985.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ou D, Metzger DL, Wang X, et al. (2003). "TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction". Diabetologia. 45 (12): 1678–88. doi:10.1007/s00125-002-0926-2. PMID 12488957.
Hasel C, Dürr S, Rau B, et al. (2003). "In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas". Lab. Invest. 83 (6): 825–36. doi:10.1097/01.lab.0000073126.56932.46. PMID 12808117.
Kotelkin A, Prikhod'ko EA, Cohen JI, et al. (2003). "Respiratory syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand". J. Virol. 77 (17): 9156–72. doi:10.1128/JVI.77.17.9156-9172.2003. PMC 187410. PMID 12915532.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Shivapurkar N, Toyooka S, Toyooka KO, et al. (2004). "Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types". Int. J. Cancer. 109 (5): 786–92. doi:10.1002/ijc.20041. PMID 14999791. S2CID 10876221.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173530 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9382840-3] Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenazi A (Feb 1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain". Curr Biol. 7 (12): 1003–6. Bibcode:1997CBio....7.1003M. doi:10.1016/S0960-9822(06)00422-2. PMID 9382840. S2CID 21645158.

[pmid9537512-4] Pan G, Ni J, Yu G, Wei YF, Dixit VM (Apr 1998). "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling" (PDF). FEBS Lett. 424 (1–2): 41–5. doi:10.1016/S0014-5793(98)00135-5. PMID 9537512. S2CID 2964615.

[entrez-5] "Entrez Gene: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain".

[1]

[2]

[3]

[4]

[5]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Function

References

Further reading