Cardiotrophin 1
| cardiotrophin 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CTF1, CT1, CT-1 | ||||||
| NCBI gene | 1489 | ||||||
| HGNC | 2499 | ||||||
| OMIM | 600435 | ||||||
| RefSeq | NM_001330 | ||||||
| UniProt | Q16619 | ||||||
| Other data | |||||||
| Locus | Chr. 16 p11.2-16p11.1 | ||||||
| |||||||
Cardiotrophin-1 (CT-1) is a cytokine. It is a cardiac hypertrophic factor of 21.5 kDa and a protein member of the IL-6 cytokine family.
Pathology
[edit]CT-1 is associated with the pathophysiology of heart diseases, including hypertension, myocardial infarction, valvular heart disease, and congestive heart failure.
Mode of action
[edit]The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-κB DNA -binding activities.
CT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine. [1]
References
[edit]- ^ "Recombinant human Cardiotrophin 1 protein (ab9838)". www.abcam.com. Retrieved 2017-08-09.
External links
[edit]- cardiotrophin+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Irving, Michael (August 8, 2017). "The protein that can make your heart think you exercise". newatlas.com. Retrieved 2017-08-09.
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