CCR10

CCR10
Identifiers
Aliases	CCR10, GPR2, C-C motif chemokine receptor 10
External IDs	OMIM: 600240; MGI: 1096320; HomoloGene: 7271; GeneCards: CCR10; OMA:CCR10 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.2 Start 42,678,889 bp End 42,683,917 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 D|11 64.34 cM Start 101,063,823 bp End 101,066,269 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Pituitary Gland anterior pituitary right hemisphere of cerebellum body of uterus left uterine tube apex of heart canal of the cervix left ovary right ovary Top expressed in embryo embryo esophagus duodenum granulocyte neural layer of retina lip jejunum muscle tissue cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function C-C chemokine receptor activity G protein-coupled receptor activity chemokine receptor activity signal transducer activity protein binding chemokine binding C-C chemokine binding Cellular component cell surface integral component of membrane plasma membrane integral component of plasma membrane membrane endoplasmic reticulum external side of plasma membrane Biological process positive regulation of cytosolic calcium ion concentration chemotaxis chemokine-mediated signaling pathway G protein-coupled receptor signaling pathway immune response signal transduction calcium-mediated signaling cell chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2826 12777 Ensembl ENSG00000184451 ENSMUSG00000044052 UniProt P46092 Q9JL21 RefSeq (mRNA) NM_016602 NM_007721 RefSeq (protein) NP_057686 NP_031747 Location (UCSC) Chr 17: 42.68 – 42.68 Mb Chr 11: 101.06 – 101.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.

Function

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.

CCR10 is a chemokine receptor. Its ligands are CCL27 and CCL28. This receptor is normally expressed by melanocytes, plasma cells and skin-homing T cells. B16 melanoma cell transduction of CCR10 significantly increases the development of lymph node metastasis in mice after inoculation in the skin, suggesting a role for the receptor in directing metastasis. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Bonini JA, Martin SK, Dralyuk F, et al. (1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3". DNA Cell Biol. 16 (10): 1249–56. doi:10.1089/dna.1997.16.1249. PMID 9364936.
• Gosling J, Dairaghi DJ, Wang Y, et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK". J. Immunol. 164 (6): 2851–6. doi:10.4049/jimmunol.164.6.2851. PMID 10706668.
• Jarmin DI, Rits M, Bota D, et al. (2000). "Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine". J. Immunol. 164 (7): 3460–4. doi:10.4049/jimmunol.164.7.3460. PMID 10725696.
• Homey B, Wang W, Soto H, et al. (2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
• Wang W, Soto H, Oldham ER, et al. (2000). "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)". J. Biol. Chem. 275 (29): 22313–23. doi:10.1074/jbc.M001461200. PMID 10781587.
• Pan J, Kunkel EJ, Gosslar U, et al. (2000). "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues". J. Immunol. 165 (6): 2943–9. doi:10.4049/jimmunol.165.6.2943. PMID 10975800.
• Patel L, Charlton SJ, Chambers JK, Macphee CH (2001). "Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations". Cytokine. 14 (1): 27–36. doi:10.1006/cyto.2000.0851. PMID 11298490.
• Homey B, Alenius H, Müller A, et al. (2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900. S2CID 35433583.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Notohamiprodjo M, Segerer S, Huss R, et al. (2005). "CCR10 is expressed in cutaneous T-cell lymphoma". Int. J. Cancer. 115 (4): 641–7. doi:10.1002/ijc.20922. PMID 15700309. S2CID 45425929.
• Rodrigues-Lisoni FC, Mehet DK, Mehemet DK, et al. (2006). "In vitro and in vivo studies on CCR10 regulation by Annexin A1". FEBS Lett. 580 (5): 1431–8. doi:10.1016/j.febslet.2006.01.072. hdl:11449/21716. PMID 16460738. S2CID 11454792.
• Fujita Y, Abe R, Sasaki M, et al. (2006). "Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides". Clin. Cancer Res. 12 (9): 2670–5. doi:10.1158/1078-0432.CCR-05-1513. PMID 16675558. S2CID 6562342.
• Eksteen B, Miles A, Curbishley SM, et al. (2006). "Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10". J. Immunol. 177 (1): 593–603. doi:10.4049/jimmunol.177.1.593. PMID 16785557. S2CID 43279609.
• Harasawa H, Yamada Y, Hieshima K, et al. (2007). "Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma". Leuk. Lymphoma. 47 (10): 2163–73. doi:10.1080/10428190600775599. PMID 17071491. S2CID 32495340.

External links

• Human CCR10 genome location and CCR10 gene details page in the UCSC Genome Browser.
• "Chemokine Receptors: CCR10". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.