Incumbent Republican Trent Kelly, who had represented the district since 2015 ran for re-election. He won a special election to replace the late Alan Nunnelee with 70% of the vote in 2015 and the district had a PVI of R+16.
Incumbent Democrat Bennie Thompson, who had represented the district since 1993, ran for re-election. He won re-election with 68% of the vote in 2014 and the district had a PVI of D+13.
Incumbent Republican Gregg Harper, who had represented the district since 2009, ran for re-election. He won re-election with 69% of the vote in 2014 and the district had a PVI of R+14.
Incumbent Republican Steven Palazzo, who had represented the district since 2011, ran for re-election. He was re-elected with 70% of the vote in 2014 and the district had a PVI of R+21.