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Ipratropium bromide/salbutamol

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Ipratropium bromide/salbutamol
Combination of
Ipratropium bromideMuscarinic antagonist
SalbutamolShort-acting β2-adrenergic agonist
Clinical data
Trade namesCombivent, Duoneb, Breva, others
AHFS/Drugs.comProfessional Drug Facts
MedlinePlusa601063
License data
Routes of
administration		Inhalation
ATC code
Legal status
Legal status
Identifiers
CAS Number
  (verify)

Ipratropium bromide/salbutamol, sold under the brand name Combivent among others, is a combination medication used to treat chronic obstructive pulmonary disease (COPD).[1][4][5] It contains ipratropium (an anticholinergic) and salbutamol (albuterol, a β2-adrenergic agonist).[1]

Common side effects include sore throat, muscle cramps, and nausea.[1] Other side effects may include bronchospasm, allergic reactions, and upper respiratory tract infections.[1] Safety in pregnancy is unclear.[6][1]

The combination was approved for medical use in the United States in 1996.[7] It is available as a generic medication.[4] In 2022, it was the 178th most commonly prescribed medication in the United States, with more than 2 million prescriptions.[8][9]

Medical uses

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Ipratropium bromide/salbutamol can be used for the treatment of COPD[5] and asthma.[10]

Society and culture

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Since Combivent contains a chlorofluorocarbon-based propellant, its use was discontinued in 2013 in the United States and other countries. This is because chlorofluorocarbons are attributed to depletion of the ozone layer.[11]

References

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  1. ^ a b c d e f "Combivent Respimat- ipratropium bromide and albuterol spray, metered". DailyMed. 24 January 2022. Retrieved 30 October 2022.
  2. ^ "DuoNeb". DailyMed. Retrieved 30 October 2022.
  3. ^ "Combivent (ipratropium bromide and albuterol sulfate) Inhalation Aerosol". DailyMed. Retrieved 30 October 2022.
  4. ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 247. ISBN 9780857113382.
  5. ^ a b Gordon J, Panos RJ (March 2010). "Inhaled albuterol/salbutamol and ipratropium bromide and their combination in the treatment of chronic obstructive pulmonary disease". Expert Opinion on Drug Metabolism & Toxicology. 6 (3): 381–92. doi:10.1517/17425251003649549. PMID 20163324. S2CID 31806856.
  6. ^ "Albuterol / ipratropium Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
  7. ^ "Ipratropium and Albuterol - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 18 April 2019.
  8. ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
  9. ^ "Albuterol; Ipratropium Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.
  10. ^ Donohue JF, Wise R, Busse WW, Garfinkel S, Zubek VB, Ghafouri M, et al. (April 2016). "Efficacy and safety of ipratropium bromide/albuterol compared with albuterol in patients with moderate-to-severe asthma: a randomized controlled trial". BMC Pulmonary Medicine. 16 (1): 65. doi:10.1186/s12890-016-0223-3. PMC 4851785. PMID 27130202.
  11. ^ "Phase Out of Combivent Inhalation Aerosol - Questions and Answers". FDA. 3 November 2018.
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