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Chemical compound
Mazaticol Routes of administration Oral ATC code Legal status
[(1R ,3R ,5R )-6,6,9-trimethyl-9-azabicyclo[3.3.1]non-3-yl hydroxy(di-2-thienyl)acetate
CAS Number PubChem CID ChemSpider UNII CompTox Dashboard (EPA ) Formula C 21 H 27 N O 3 S 2 Molar mass 405.57 g·mol−1 3D model (JSmol )
CC1(CC[C@@H]2C[C@H](C[C@H]1N2C)OC(=O)C(c3cccs3)(c4cccs4)O)C
InChI=1S/C21H27NO3S2/c1-20(2)9-8-14-12-15(13-16(20)22(14)3)25-19(23)21(24,17-6-4-10-26-17)18-7-5-11-27-18/h4-7,10-11,14-16,24H,8-9,12-13H2,1-3H3/t14-,15-,16-/m1/s1
Key:AMHPTVWBZSYFSS-BZUAXINKSA-N
(verify)
Mazaticol (Pentona ) is an anticholinergic used as an antiparkinsonian agent in Japan.
The compound was known as PG-501 is first mentioned in Japanese studies in the early 1970s, noting "PG-501 was found to have pronounced anti-acetylcholine, anti-tremorine-induced tremor, anti-physostigmine-induced death, anti-haloperidol-induced parkinsonism and anti EEG arousal activities."[ 1] [ 2]
^ Nose T, Kojima M, Ishida R, Shintomi K, Kowa Y (July 1971). "[Pharmacological properties of 6,6,9-trimethyl-9-azabicyclo (3,3,1)non-3 beta-yl-alpha, alpha-di(2-thienyl) glycolate hydrochloride monohydrate (PG-501), a new anti-parkinsonian agent]" . Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 67 (4): 387–405. doi :10.1254/fpj.67.387 . PMID 5000167 .
^ Kosaka K (1971). "パ ー キ ン ソ ン病 に対 す るPG-501の 使 用 経 験/The Beneficial Effect of PG-501 on Parkinsonism" . Rinsho Yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics . 2 (3): 230–235. doi :10.3999/jscpt.2.230 . Retrieved December 18, 2023 .
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