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Chemical compound
Piroheptine (brand name Trimol ) is an anticholinergic and antihistamine used as an antiparkinsonian agent.
Piroheptine was observed to prevent the reuptake of dopamine and is therefore a DRI .[ 1] [ 2]
Piroheptine comes from a family of drugs that includes pridefine and etifelmine .
^ Saitoh T (February 1988). "Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mouse brain by piroheptine and trihexyphenidyl". Journal of the Neurological Sciences . 83 (2–3): 161–166. doi :10.1016/0022-510X(88)90065-2 . PMID 3258627 . S2CID 25230405 .
^ Ohashi T, Akita H, Tamura T, Noda K, Honda F (June 1972). "Effect of piroheptine, a new antiparkinson drug, on dopamine uptake into synaptosomes from corpus striatum of rat brain". Arzneimittel-Forschung . 22 (6): 966–972. PMID 5068358 .
H1
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H2
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RU-47,213
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WIN-2299
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Precursors (and prodrugs )