Benapryzine

Benapryzine
Clinical data
Trade names	Brizin
Other names	Benapryzine; Beneprizine; Benepryzine; BRL-1288; BRL1288; AP-1288; AP1288
Routes of; administration	Oral
Identifiers
	IUPAC name 2-[ethyl(propyl)amino]ethyl 2-hydroxy-2,2-diphenylacetate;
CAS Number	22487-42-9 ; 3202-55-9 (hydrochloride);
PubChem CID	18551;
ChemSpider	17520;
UNII	14FPC4V3AX;
ChEBI	CHEBI:191253;
ChEMBL	ChEMBL2110766;
CompTox Dashboard (EPA)	DTXSID00865055 ;
Chemical and physical data
Formula	C21H27NO3
Molar mass	341.451 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCN(CC)CCOC(=O)C(C1=CC=CC=C1)(C2=CC=CC=C2)O;
	InChI InChI=1S/C21H27NO3/c1-3-15-22(4-2)16-17-25-20(23)21(24,18-11-7-5-8-12-18)19-13-9-6-10-14-19/h5-14,24H,3-4,15-17H2,1-2H3; Key:PYPJRLVCFAVWFR-UHFFFAOYSA-N;

Benapryzine (BANTooltip British Approved Name), or benaprizine (INNTooltip International Nonproprietary Name), also known as benapryzine hydrochloride (USANTooltip United States Adopted Name in the case of the hydrochloride salt and sold under the brand name Brizin, is an antiparkinsonian agent and anticholinergic which has been used in the treatment of parkinsonism.^[2]^[3]^[4]^[1] As an anticholinergic, it is specifically a muscarinic acetylcholine receptor antagonist.^[1] Structurally, benapryzine is a benzilate, and is closely related to other antimuscarinic benzilate derivatives like benactyzine.^[4] The drug was first described in the literature by 1973.^[2]^[5]

References

^ ^a ^b ^c "Benapryzine". Inxight Drugs. Retrieved 21 October 2024.
^ ^a ^b Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 125. ISBN 978-1-4757-2085-3. Retrieved 21 October 2024.
^ Negwer M, Scharnow HG (2001). Organic-chemical Drugs and Their Synonyms: An International Survey. Wiley-VCH. p. 2143. ISBN 978-3-527-30247-5. Retrieved 21 October 2024.
^ ^a ^b Morton IK, Hall JM (2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Netherlands. p. 46. ISBN 978-94-011-4439-1. Retrieved 21 October 2024.
^ CatchWord Ltd (1971). Xenobiotica. Taylor & Francis. p. 176. Retrieved 21 October 2024. Benactyzine, which differs from Benapryzine only by the presence of an ethyl group in place of the n-propyl group, can be dealkylated before being hydrolysed.

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