Didesmethylcitalopram

Didesmethylcitalopram
Clinical data
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Pharmacokinetic data
Elimination half-life	100 h
Identifiers
	IUPAC name (RS or S)-1-[3-aminopropyl]-1-; (4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile;
CAS Number	62498-69-5 ;
ChemSpider	23935928 ;
UNII	ZE9YVI4ZEE;
CompTox Dashboard (EPA)	DTXSID30168066 ;
Chemical and physical data
Formula	C18H17FN2O
Molar mass	296.345 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1cc(ccc1[C@]2(c3ccc(cc3CO2)C#N)CCCN)F;
	InChI InChI=1S/C18H17FN2O/c19-16-5-3-15(4-6-16)18(8-1-9-20)17-7-2-13(11-21)10-14(17)12-22-18/h2-7,10H,1,8-9,12,20H2/t18-/m0/s1 ; Key:RKUKMUWCRLRPEJ-SFHVURJKSA-N ;
	(what is this?) (verify)

Didesmethylcitalopram is an active metabolite of the antidepressant drug citalopram (racemic).^[1] Didesmethylescitalopram is an active metabolite of the antidepressant escitalopram, the S-enantiomer of citalopram. Like citalopram and escitalopram, didesmethyl(es)citalopram functions as a selective serotonin reuptake inhibitor (SSRI), and is responsible for some of its parents' therapeutic benefits.

References

^ Rop PP, Durand A, Viala A, Jørgensen A (April 1990). "Simultaneous determination of citalopram, monodesmethylcitalopram and didesmethylcitalopram in plasma by high-performance liquid chromatography after column extraction". Journal of Chromatography. 527 (1): 226–32. doi:10.1016/s0378-4347(00)82105-2. PMID 2365786.

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