SOX12

SOX12
Identifiers
Aliases	SOX12, SOX22, SRY-box 12, SRY-box transcription factor 12
External IDs	OMIM: 601947; MGI: 98360; HomoloGene: 5057; GeneCards: SOX12; OMA:SOX12 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	330,224 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	152,239,983 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; stromal cell of endometrium; ; apex of heart; ; right hemisphere of cerebellum; ; right uterine tube; ; right adrenal cortex; ; sural nerve; ; right ovary; ; right frontal lobe;
	Top expressed in
	aortic valve; ; Gonadal ridge; ; genital tubercle; ; somite; ; ventricular zone; ; ascending aorta; ; maxillary prominence; ; mandibular prominence; ; internal carotid artery; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription cis-regulatory region binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	protein-DNA complex; nucleus; nucleoplasm; cellular component;
Biological process	regulation of transcription by RNA polymerase II; protein-DNA complex assembly; cell fate commitment; regulation of transcription, DNA-templated; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; spinal cord development; transcription, DNA-templated; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	6666
	20667
	ENSG00000177732
	ENSMUSG00000051817
	O15370
	Q04890
	NM_006943
	NM_011438
	NP_008874
	NP_035568
	Wikidata
View/Edit Human	View/Edit Mouse

SOX12 is a protein that in humans is encoded by the SOX12 gene.^[5]^[6] Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11.^[7] Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.^[8]

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177732 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051817 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jay P, Sahly I, Goze C, Taviaux S, Poulat F, Couly G, Abitbol M, Berta P (Aug 1997). "SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue". Hum Mol Genet. 6 (7): 1069–77. doi:10.1093/hmg/6.7.1069. PMID 9215677.
^ ^a ^b "Entrez Gene: SOX12 SRY (sex determining region Y)-box 12".
^ Hoser M, Potzner MR, Koch JM, Bösl MR, Wegner M, Sock E (August 2008). "Sox12 Deletion in the Mouse Reveals Nonreciprocal Redundancy with the Related Sox4 and Sox11 Transcription Factors". Mol. Cell. Biol. 28 (15): 4675–87. doi:10.1128/MCB.00338-08. PMC 2493363. PMID 18505825.
^ Dy P, Penzo-Méndez A, Wang H, Pedraza CE, Macklin WB, Lefebvre V (May 2008). "The three SoxC proteins—Sox4, Sox11 and Sox12—exhibit overlapping expression patterns and molecular properties". Nucleic Acids Res. 36 (9): 3101–17. doi:10.1093/nar/gkn162. PMC 2396431. PMID 18403418.

References

Further reading