CEBPD

CEBPD
Identifiers
Aliases	CEBPD, C/EBP-delta, CELF, CRP3, NF-IL6-beta, CCAAT/enhancer binding protein delta, CCAAT enhancer binding protein delta
External IDs	OMIM: 116898; MGI: 103573; HomoloGene: 3808; GeneCards: CEBPD; OMA:CEBPD - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	47,738,164 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	15,708,895 bp
RNA expression pattern
	Top expressed in
	pericardium; ; vena cava; ; lower lobe of lung; ; trachea; ; cardia; ; beta cell; ; mucosa of paranasal sinus; ; olfactory bulb; ; cartilage tissue; ; gastric mucosa;
	Top expressed in
	left lung lobe; ; granulocyte; ; umbilical cord; ; endothelial cell of lymphatic vessel; ; gastrula; ; right lung; ; muscle of thigh; ; carotid body; ; ankle; ; ankle joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein homodimerization activity; protein heterodimerization activity;
Cellular component	nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; cytokine-mediated signaling pathway; hematopoietic progenitor cell differentiation; regulation of transcription by RNA polymerase II; fat cell differentiation; positive regulation of osteoblast differentiation; negative regulation of transcription, DNA-templated; inner ear development;
	Sources:Amigo / QuickGO
Orthologs
	1052
	12609
	ENSG00000221869
	ENSMUSG00000071637
	P49716
	Q00322
	NM_005195
	NM_007679
	NP_005186
	NP_031705
	Wikidata
View/Edit Human	View/Edit Mouse

CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.^[5]^[6]

Function

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.^[7]

Functions

CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.^[8]

One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.^[9]

Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.^[10]

Interactions

CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000221869 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071637 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cao Z, Umek RM, McKnight SL (September 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development. 5 (9): 1538–1552. doi:10.1101/gad.5.9.1538. PMID 1840554.
^ Williams SC, Cantwell CA, Johnson PF (September 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes & Development. 5 (9): 1553–1567. doi:10.1101/gad.5.9.1553. PMID 1884998.
^ "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta".
^ Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP (February 2005). "C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation". Oncogene. 24 (9): 1589–1597. doi:10.1038/sj.onc.1208393. PMID 15674331. S2CID 24347537.
^ Duitman J, Borensztajn KS, Pulskens WP, Leemans JC, Florquin S, Spek CA (January 2014). "CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (1): 89–97. doi:10.1038/labinvest.2013.127. PMID 24247561.
^ Munkácsy G, Sztupinszki Z, Herman P, Bán B, Pénzváltó Z, Szarvas N, et al. (September 2016). "Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments". Molecular Therapy. Nucleic Acids. 5 (9): e366. doi:10.1038/mtna.2016.66. PMC 5056990. PMID 27673562.
^ Choy L, Derynck R (March 2003). "Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function". The Journal of Biological Chemistry. 278 (11): 9609–9619. doi:10.1074/jbc.M212259200. PMID 12524424.

External links

Human CEBPD genome location and CEBPD gene details page in the UCSC Genome Browser.
CEBPD+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000221869 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071637 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1840554-5] Cao Z, Umek RM, McKnight SL (September 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development. 5 (9): 1538–1552. doi:10.1101/gad.5.9.1538. PMID 1840554.

[pmid1884998-6] Williams SC, Cantwell CA, Johnson PF (September 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes & Development. 5 (9): 1553–1567. doi:10.1101/gad.5.9.1553. PMID 1884998.

[entrez-7] "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta".

[pmid_=_15674331-8] Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP (February 2005). "C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation". Oncogene. 24 (9): 1589–1597. doi:10.1038/sj.onc.1208393. PMID 15674331. S2CID 24347537.

[pmid_=_24247561-9] Duitman J, Borensztajn KS, Pulskens WP, Leemans JC, Florquin S, Spek CA (January 2014). "CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (1): 89–97. doi:10.1038/labinvest.2013.127. PMID 24247561.

[10] Munkácsy G, Sztupinszki Z, Herman P, Bán B, Pénzváltó Z, Szarvas N, et al. (September 2016). "Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments". Molecular Therapy. Nucleic Acids. 5 (9): e366. doi:10.1038/mtna.2016.66. PMC 5056990. PMID 27673562.

[pmid12524424-11] Choy L, Derynck R (March 2003). "Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function". The Journal of Biological Chemistry. 278 (11): 9609–9619. doi:10.1074/jbc.M212259200. PMID 12524424.

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