LYL1

LYL1
Identifiers
Aliases	LYL1, bHLHa18, lymphoblastic leukemia associated hematopoiesis regulator 1, basic helix-loop-helix family member, LYL1 basic helix-loop-helix family member
External IDs	OMIM: 151440; MGI: 96891; HomoloGene: 4078; GeneCards: LYL1; OMA:LYL1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.13 Start 13,099,033 bp End 13,103,161 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 C3|8 41.02 cM Start 85,428,078 bp End 85,431,569 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood granulocyte monocyte trabecular bone bone marrow spleen bone marrow cells vena cava superficial temporal artery lymph node Top expressed in granulocyte spleen bone marrow tibiofemoral joint stroma of bone marrow fetal liver hematopoietic progenitor cell blood mesenteric lymph nodes interventricular septum endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process positive regulation of transcription, DNA-templated B cell differentiation definitive hemopoiesis regulation of transcription, DNA-templated transcription, DNA-templated blood vessel maturation regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4066 17095 Ensembl ENSG00000104903 ENSMUSG00000034041 UniProt P12980 P27792 RefSeq (mRNA) NM_005583 NM_008535 RefSeq (protein) NP_005574 NP_032561 Location (UCSC) Chr 19: 13.1 – 13.1 Mb Chr 8: 85.43 – 85.43 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.

Interactions

LYL1 has been shown to interact with TCF3 and NFKB1.

Further reading

• Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ (December 1991). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proceedings of the National Academy of Sciences of the United States of America. 88 (24): 11416–20. Bibcode:1991PNAS...8811416X. doi:10.1073/pnas.88.24.11416. PMC 53146. PMID 1763056.
• Kuo SS, Mellentin JD, Copeland NG, Gilbert DJ, Jenkins NA, Cleary ML (June 1991). "Structure, chromosome mapping, and expression of the mouse Lyl-1 gene". Oncogene. 6 (6): 961–8. PMID 2067848.
• Saltman DL, Mellentin JD, Smith SD, Cleary ML (November 1990). "Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization". Genes, Chromosomes & Cancer. 2 (4): 259–65. doi:10.1002/gcc.2870020402. PMID 2268576. S2CID 103922.
• Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". The EMBO Journal. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
• Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A (January 1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.
• Miyamoto A, Cui X, Naumovski L, Cleary ML (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Molecular and Cellular Biology. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. PMC 231228. PMID 8628307.
• Mahajan MA, Park ST, Sun XH (June 1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins". Oncogene. 12 (11): 2343–50. PMID 8649774.
• Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (January 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene. 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. PMID 10023675.
• Meng YS, Khoury H, Dick JE, Minden MD (November 2005). "Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia". Leukemia. 19 (11): 1941–7. doi:10.1038/sj.leu.2403836. PMID 16094422.

External links

• LYL1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)