MNT (gene)

MNT
Identifiers
Aliases	MNT, MAD6, MXD6, ROX, bHLHd3, MAX network transcriptional repressor, lncRNA-HAL
External IDs	OMIM: 603039; MGI: 109150; HomoloGene: 7842; GeneCards: MNT; OMA:MNT - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	2,401,104 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	74,736,551 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; Region I of hippocampus proper; ; endothelial cell; ; dorsal motor nucleus of vagus nerve; ; Brodmann area 10; ; sural nerve; ; gingival epithelium; ; orbitofrontal cortex; ; tendon of biceps brachii;
	Top expressed in
	Rostral migratory stream; ; motor neuron; ; stroma of bone marrow; ; iris; ; ciliary body; ; gastrula; ; vestibular membrane of cochlear duct; ; substantia nigra; ; blood; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; transcription coactivator activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; chromatin binding; protein dimerization activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	multicellular organism development; negative regulation of apoptotic signaling pathway; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; negative regulation of cell population proliferation; regulation of cell cycle; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	4335
	17428
	ENSG00000070444
	ENSMUSG00000000282
	Q99583
	O08789
	NM_020310
	NM_010813
	NP_064706
	NP_034943
	Wikidata
View/Edit Human	View/Edit Mouse

MNT (Max-binding protein MNT) is a Max-binding protein that is encoded by the MNT gene^[5]^[6]^[7]

Function

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. Its delta signature is 44. This protein is a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA and recruiting Sin3 corepressor proteins through its N-terminal Sin3-interaction domain ^[5]^[8]

Interactions

MNT (gene) has been shown to interact with MLX,^[9]^[10] SIN3A^[11] and MAX.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000070444 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000282 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Hurlin PJ, Quéva C, Eisenman RN (January 1997). "Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites". Genes & Development. 11 (1): 44–58. doi:10.1101/gad.11.1.44. PMID 9000049.
^ Lo Nigro C, Venesio T, Reymond A, Meroni G, Alberici P, Cainarca S, Enrico F, Stack M, Ledbetter DH, Liscia DS, Ballabio A, Carrozzo R (April 1998). "The human ROX gene: genomic structure and mutation analysis in human breast tumors". Genomics. 49 (2): 275–282. doi:10.1006/geno.1998.5241. PMID 9598315.
^ "Entrez Gene: MNT MAX binding protein".
^ Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal. 16 (10): 2892–2906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233.
^ Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617–627. doi:10.1093/hmg/10.6.617. PMID 11230181.
^ Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene. 19 (29): 3266–3277. doi:10.1038/sj.onc.1203634. PMID 10918583.
^ ^a ^b Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal. 16 (10): 2892–2906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233.

External links

MNT+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000070444 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000282 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[ReferenceA-5] Hurlin PJ, Quéva C, Eisenman RN (January 1997). "Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites". Genes & Development. 11 (1): 44–58. doi:10.1101/gad.11.1.44. PMID 9000049.

[pmid9598315-6] Lo Nigro C, Venesio T, Reymond A, Meroni G, Alberici P, Cainarca S, Enrico F, Stack M, Ledbetter DH, Liscia DS, Ballabio A, Carrozzo R (April 1998). "The human ROX gene: genomic structure and mutation analysis in human breast tumors". Genomics. 49 (2): 275–282. doi:10.1006/geno.1998.5241. PMID 9598315.

[entrez-7] "Entrez Gene: MNT MAX binding protein".

[8] Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal. 16 (10): 2892–2906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233.

[pmid11230181-9] Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617–627. doi:10.1093/hmg/10.6.617. PMID 11230181.

[pmid10918583-10] Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene. 19 (29): 3266–3277. doi:10.1038/sj.onc.1203634. PMID 10918583.

[pmid9184233-11] Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal. 16 (10): 2892–2906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233.

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Function

Interactions

References

Further reading

External links