NFIA

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NFIA
Identifiers
Aliases	NFIA, CTF, NF-I/A, NF1-A, NFI-A, NFI-L, nuclear factor I A, BRMUTD
External IDs	OMIM: 600727; MGI: 108056; HomoloGene: 4086; GeneCards: NFIA; OMA:NFIA - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p31.3 Start 60,865,259 bp End 61,462,788 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 C5- C6|4 45.52 cM Start 97,660,971 bp End 98,007,111 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus urethra saphenous vein vena cava buccal mucosa cell cardia nipple parietal pleura endothelial cell synovial joint Top expressed in seminal vesicula vestibular membrane of cochlear duct vestibular sensory epithelium external carotid artery Rostral migratory stream internal carotid artery lobe of cerebellum cerebellar vermis atrioventricular valve facial motor nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding chromatin binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cell junction intracellular anatomical structure nucleus nucleoplasm Biological process viral genome replication DNA replication regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated synapse maturation transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II ureter development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4774 18027 Ensembl ENSG00000162599 ENSMUSG00000028565 UniProt Q12857 Q02780 RefSeq (mRNA) NM_001134673 NM_001145511 NM_001145512 NM_005595 NM_001122952 NM_001122953 NM_010905 RefSeq (protein) NP_001128145 NP_001138983 NP_001138984 NP_005586 NP_001116424 NP_001116425 NP_035035 Location (UCSC) Chr 1: 60.87 – 61.46 Mb Chr 4: 97.66 – 98.01 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Nuclear factor 1 A-type is a protein that in humans is encoded by the NFIA gene.

Function

Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. They function as cellular transcription factors and as replication factors for adenovirus DNA replication. Diversity in this protein family is generated by multiple genes, differential splicing, and heterodimerization.[supplied by OMIM]

Further reading

• Leahy P, Crawford DR, Grossman G, Gronostajski RM, Hanson RW (March 1999). "CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription". The Journal of Biological Chemistry. 274 (13): 8813–22. doi:10.1074/jbc.274.13.8813. PMID 10085123.
• das Neves L, Duchala CS, Tolentino-Silva F, Haxhiu MA, Colmenares C, Macklin WB, Campbell CE, Butz KG, Gronostajski RM, Godinho F (October 1999). "Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum". Proceedings of the National Academy of Sciences of the United States of America. 96 (21): 11946–51. Bibcode:1999PNAS...9611946D. doi:10.1073/pnas.96.21.11946. PMC 18392. PMID 10518556.
• Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (February 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Xu H, Uno JK, Inouye M, Collins JF, Ghishan FK (February 2005). "NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene". American Journal of Physiology. Gastrointestinal and Liver Physiology. 288 (2): G175-81. doi:10.1152/ajpgi.00396.2004. PMID 15458926. S2CID 14194207.
• Wang W, Stock RE, Gronostajski RM, Wong YW, Schachner M, Kilpatrick DL (December 2004). "A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression". The Journal of Biological Chemistry. 279 (51): 53491–7. doi:10.1074/jbc.M410370200. PMID 15466411.
• Champ PC, Maurice S, Vargason JM, Camp T, Ho PS (2005). "Distributions of Z-DNA and nuclear factor I in human chromosome 22: a model for coupled transcriptional regulation". Nucleic Acids Research. 32 (22): 6501–10. doi:10.1093/nar/gkh988. PMC 545456. PMID 15598822.
• Berry FB, O'Neill MA, Coca-Prados M, Walter MA (February 2005). "FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner". Molecular and Cellular Biology. 25 (4): 1415–24. doi:10.1128/MCB.25.4.1415-1424.2005. PMC 548007. PMID 15684392.
• Fazi F, Rosa A, Fatica A, Gelmetti V, De Marchis ML, Nervi C, Bozzoni I (December 2005). "A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis". Cell. 123 (5): 819–31. doi:10.1016/j.cell.2005.09.023. PMID 16325577. S2CID 6003724.
• Lin YL, Wang YH, Lee HJ (November 2006). "Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A". Biochemical and Biophysical Research Communications. 350 (2): 430–6. doi:10.1016/j.bbrc.2006.09.061. PMID 17010934.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Lu W, Quintero-Rivera F, Fan Y, Alkuraya FS, Donovan DJ, Xi Q, Turbe-Doan A, Li QG, Campbell CG, Shanske AL, Sherr EH, Ahmad A, Peters R, Rilliet B, Parvex P, Bassuk AG, Harris DJ, Ferguson H, Kelly C, Walsh CA, Gronostajski RM, Devriendt K, Higgins A, Ligon AH, Quade BJ, Morton CC, Gusella JF, Maas RL (May 2007). "NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects". PLOS Genetics. 3 (5): e80. doi:10.1371/journal.pgen.0030080. PMC 1877820. PMID 17530927.

External links

• NFIA+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.