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PRDM2

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PRDM2
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesPRDM2, HUMHOXY1, KMT8, MTB-ZF, RIZ, RIZ1, RIZ2, PR domain 2, PR/SET domain 2, KMT8A
External IDsOMIM: 601196; MGI: 107628; HomoloGene: 40822; GeneCards: PRDM2; OMA:PRDM2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001081355
NM_001256380

RefSeq (protein)

NP_001007258
NP_001129082
NP_036363
NP_056950

n/a

Location (UCSC)Chr 1: 13.7 – 13.83 MbChr 4: 143.11 – 143.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PR domain zinc finger protein 2 is a protein that in humans is encoded by the PRDM2 gene.[5][6]

Function

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This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.[6]

Interactions

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PRDM2 has been shown to interact with Estrogen receptor alpha[7] and Retinoblastoma protein.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116731Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057637Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Buyse IM, Shao G, Huang S (May 1995). "The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein". Proceedings of the National Academy of Sciences of the United States of America. 92 (10): 4467–71. Bibcode:1995PNAS...92.4467B. doi:10.1073/pnas.92.10.4467. PMC 41965. PMID 7538672.
  6. ^ a b "Entrez Gene: PRDM2 PR domain containing 2, with ZNF domain".
  7. ^ Abbondanza C, Medici N, Nigro V, Rossi V, Gallo L, Piluso G, Belsito A, Roscigno A, Bontempo P, Puca AA, Molinari AM, Moncharmont B, Puca GA (Mar 2000). "The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3130–5. doi:10.1073/pnas.050015697. PMC 16204. PMID 10706618.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.