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MEIS1

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MEIS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMEIS1, Meis homeobox 1
External IDsOMIM: 601739; MGI: 104717; HomoloGene: 135741; GeneCards: MEIS1; OMA:MEIS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002398

NM_001193271
NM_010789

RefSeq (protein)

NP_002389

NP_001180200
NP_034919

Location (UCSC)Chr 2: 66.43 – 66.57 MbChr 11: 18.83 – 18.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.[5][6]

Function

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Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.[6]

Interactions

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MEIS1 has been shown to interact with PBX1[7][8][9] and HOXA9.[7][10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143995Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020160Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM (October 1995). "Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice". Molecular and Cellular Biology. 15 (10): 5434–5443. doi:10.1128/mcb.15.10.5434. PMC 230793. PMID 7565694.
  6. ^ a b "Entrez Gene: MEIS1 Meis homeobox 1".
  7. ^ a b Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (April 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–3061. doi:10.1128/mcb.19.4.3051. PMC 84099. PMID 10082572.
  8. ^ Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (November 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology. 19 (11): 7577–7588. doi:10.1128/mcb.19.11.7577. PMC 84774. PMID 10523646.
  9. ^ Jacobs Y, Schnabel CA, Cleary ML (July 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology. 19 (7): 5134–5142. doi:10.1128/mcb.19.7.5134. PMC 84356. PMID 10373562.
  10. ^ Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, et al. (November 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology. 17 (11): 6448–6458. doi:10.1128/MCB.17.11.6448. PMC 232497. PMID 9343407.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.