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HOXB9

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HOXB9
Identifiers
AliasesHOXB9, HOX-2.5, HOX2, HOX2E, homeobox B9
External IDsOMIM: 142964; MGI: 96190; HomoloGene: 7367; GeneCards: HOXB9; OMA:HOXB9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024017

NM_008270

RefSeq (protein)

NP_076922

NP_032296

Location (UCSC)Chr 17: 48.62 – 48.63 MbChr 11: 96.16 – 96.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.[5][6][7]

Function

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This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer.[7]

Interactions

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HOXB9 has been shown to interact with BTG2[8] and BTG1.[8]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170689Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020875Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. ^ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
  7. ^ a b "Entrez Gene: HOXB9 homeobox B9".
  8. ^ a b Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, Corbo L (January 2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. doi:10.1074/jbc.275.1.147. PMID 10617598.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.