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HOXA7

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HOXA7
Identifiers
AliasesHOXA7, ANTP, HOX1, HOX1.1, HOX1A, homeobox A7
External IDsOMIM: 142950; MGI: 96179; HomoloGene: 56001; GeneCards: HOXA7; OMA:HOXA7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006896

NM_010455

RefSeq (protein)

NP_008827

NP_034585

Location (UCSC)Chr 7: 27.15 – 27.16 MbChr 6: 52.19 – 52.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.[5][6][7]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122592Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038236Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. ^ Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–553. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
  7. ^ a b "Entrez Gene: HOXA7 homeobox A7".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.