Glycopyrronium tosylate

Glycopyrronium tosylate
Clinical data
Trade names	Qbrexza, Rapifort
Other names	Glycopyrronium tosilate hydrate (JAN JP)
AHFS/Drugs.com	Monograph
License data	US DailyMed: Glycopyrronium;
Routes of; administration	Topical
Drug class	Muscarinic antagonist
ATC code	D11AA01 (WHO) ;
Legal status
Legal status	US: ℞-only; In general: ℞ (Prescription only);
Identifiers
CAS Number	1624259-25-1;
PubChem CID	121225724;
DrugBank	DBSALT002800;
ChemSpider	58902513;
UNII	1PVF6JLU7B;
KEGG	D10939;
ChEMBL	ChEMBL3707243;
Chemical and physical data
3D model (JSmol)	Interactive image;
	SMILES O.Cc1ccc(cc1)S(=O)(=O)[O-].C[N+]2(C)CC[C@@H](C2)OC(=O)[C@@](O)(C3CCCC3)c4ccccc4;
	InChI InChI=1S/C19H28NO3.C7H8O3S.H2O/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15;1-6-2-4-7(5-3-6)11(8,9)10;/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3;2-5H,1H3,(H,8,9,10);1H2/q+1;;/p-1/t17-,19-;;/m0../s1; Key:UOWOLENSDISMPG-FFUVTKDNSA-M;

Glycopyrronium tosylate, sold under the brand name Qbrexza among others, is a medication used for the treatment of primary axillary hyperhidrosis.^[1]^[2]^[3]

It was approved for medical use in the United States in June 2018,^[4] and in Japan in January 2022.^[5]

References

^ ^a ^b "Qbrexza- glycopyrronium cloth". DailyMed. 17 January 2022. Retrieved 2 November 2022.
^ Nwannunu CE, Limmer AL, Coleman K, Shah R, Patel RR, Mui UN, Tyring SK (March 2019). "Glycopyrronium Tosylate (Qbrexza) for Hyperhidrosis". Skin Therapy Letter. 24 (2): 1–3. PMID 30970203.
^ Lamb YN (November 2019). "Topical Glycopyrronium Tosylate in Primary Axillary Hyperhidrosis: A Profile of Its Use". Clinical Drug Investigation. 39 (11): 1141–1147. doi:10.1007/s40261-019-00853-x. PMC 6877702. PMID 31571127.
^ "Drug Approval Package: Qbrexza (glycopyrronium)". U.S. Food and Drug Administration (FDA). 20 November 2018. Retrieved 1 November 2022.
^ "Maruho Launches Primary Axillary Hyperhidrosis Treatment". Maruho. 23 May 2022. Retrieved 2 November 2022.

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[Qbrexza_FDA_label-1] "Qbrexza- glycopyrronium cloth". DailyMed. 17 January 2022. Retrieved 2 November 2022.

[pmid30970203-2] Nwannunu CE, Limmer AL, Coleman K, Shah R, Patel RR, Mui UN, Tyring SK (March 2019). "Glycopyrronium Tosylate (Qbrexza) for Hyperhidrosis". Skin Therapy Letter. 24 (2): 1–3. PMID 30970203.

[pmid31571127-3] Lamb YN (November 2019). "Topical Glycopyrronium Tosylate in Primary Axillary Hyperhidrosis: A Profile of Its Use". Clinical Drug Investigation. 39 (11): 1141–1147. doi:10.1007/s40261-019-00853-x. PMC 6877702. PMID 31571127.

[4] "Drug Approval Package: Qbrexza (glycopyrronium)". U.S. Food and Drug Administration (FDA). 20 November 2018. Retrieved 1 November 2022.

[5] "Maruho Launches Primary Axillary Hyperhidrosis Treatment". Maruho. 23 May 2022. Retrieved 2 November 2022.

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v t e Other dermatological preparations (D11)
Anti-seborrheics	Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide) Ciclopirox olamine (ciclopirox) Climbazole Clotrimazole Ketoconazole Miconazole Piroctone olamine Selenium disulfide (selenium sulfide) Xenysalate Zinc pyrithione (pyrithione zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea (urea-containing cream) Lithium salts Lithium gluconate Lithium succinate Topical corticosteroids (e.g., hydrocortisone)
Skin lightening	Hydroquinone Mequinol Monobenzone
Skin darkening	Afamelanotide Melanotan II
Anti-inflammatories	Alitretinoin Gamolenic acid Oxaceprol Pimecrolimus Tacrolimus Topical corticosteroids (e.g., hydrocortisone)
Alopecia treatments	5α-Reductase inhibitors Alfatradiol Dutasteride Finasteride Saw palmetto extract Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Topilutamide (fluridil) Potassium channel openers Minoxidil Others Nepidermin Ritlecitinib
Hair growth inhibitors	5α-Reductase inhibitors Dutasteride Finasteride Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Eflornithine
Others	Abrocitinib Aminobenzoate potassium Androgens (e.g., testosterone) Benzoylperoxide Brimonidine Caffeine Calcium gluconate Collagen Crisaborole Cromoglicic acid Delgocitinib Deoxycholic acid Diclofenac Dupilumab Estrogens (e.g., estradiol) Glycopyrronium bromide Glycopyrronium tosylate Hyaluronic acid Hydrogen peroxide Ivermectin Lebrikizumab Lokivetmab Magnesium sulfate Metandienone Nemolizumab Oclacitinib Oxymetazoline Povidone-iodine Pregnenolone acetate Progestogens (e.g., progesterone) Ruxolitinib Tiratricol Tralokinumab