The 1980 United States Senate election in Indiana took place on November 4, 1980, along with elections to the United States Senate in other states as well as the presidential election, elections to the United States House of Representatives and various state and local elections. Incumbent Democratic U.S. Senator Birch Bayh ran for a fourth term, but was defeated by Republican nominee, U.S. Representative Dan Quayle. Dan Quayle's swearing-in marked the first time since 1959 that Republicans held both United States Senate seats from Indiana.