Leukotriene receptor
(Redirected from Leukotriene receptors)
The leukotriene (LT) receptors are G protein-coupled receptors that bind and are activated by the leukotrienes. They include the following proteins:
- Leukotriene B4 receptors (BLTRs) – bind to and are activated by LTB4:
- BLT1 (Leukotriene B4 receptor 1) – LTB4R
- BLT2 (Leukotriene B4 receptor 2) – LTB4R2
- Cysteinyl leukotriene receptors (CysLTRs) – bind to and are activated by LTC4, LTD4, and LTE4:
- CysLT1 (Cysteinyl leukotriene receptor 1) – CYSLTR1
- CysLT2 (Cysteinyl leukotriene receptor 2) – CYSLTR2
The recently elucidated CysLTE, represented by GPR99/OXGR1, may constitute a third CysLTR.[1]
See also
[edit]References
[edit]- ^ Kanaoka Y, Maekawa A, Austen KF (2013). "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand". J. Biol. Chem. 288 (16): 10967–72. doi:10.1074/jbc.C113.453704. PMC 3630866. PMID 23504326.
External links
[edit]- IUPHAR GPCR Database – Leukotriene receptors
- Leukotriene+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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