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GPR34

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GPR34
Identifiers
AliasesGPR34, LYPSR1, G protein-coupled receptor 34
External IDsOMIM: 300241; MGI: 1346334; HomoloGene: 36174; GeneCards: GPR34; OMA:GPR34 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001033513
NM_001033514
NM_001097579
NM_005300

NM_011823

RefSeq (protein)

NP_001091048
NP_005291

NP_035953

Location (UCSC)Chr X: 41.69 – 41.7 MbChr X: 13.5 – 13.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 34 is a protein that in humans is encoded by the GPR34 gene.[5][6][7] The receptor binds to lysophosphatidylserine. [8]

Function

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G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171659Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040229Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schöneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G, Gudermann T (July 1999). "A novel subgroup of class I G-protein-coupled receptors". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1446 (1–2): 57–70. doi:10.1016/s0167-4781(99)00081-0. PMID 10395919.
  6. ^ Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (February 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181.
  7. ^ a b "Entrez Gene: GPR34 G protein-coupled receptor 34".
  8. ^ Sugo T, Tachimoto H, Chikatsu T, Murakami Y, Kikukawa Y, Sato S; et al. (2006). "Identification of a lysophosphatidylserine receptor on mast cells". Biochem Biophys Res Commun. 341 (4): 1078–87. doi:10.1016/j.bbrc.2006.01.069. PMID 16460680.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Further reading

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