Lysophosphatidylserine

A lysophosphatidylserine is a lysophospholipid. Various lysophosphatidylserines trigger TLR 2.^[1] They can also modulate T cell function via suppression of Interleukin_2 (IL-2) production in CD4 T cells.^[2] They can also trigger mast cell degranulation.^[3] They interact with three G protein-coupled receptors (GPCRs), LPS1/GPR34, LPS2/P2Y10, and LPS3/GPR174.^[2]

A recent study showed that lysophosphatidylserines do not stimulate normal leukocytes.^[4] They also enhances glucose transport, lowering blood glucose levels while leaving secretion of insulin unaffected.^[5]

References

^ van der Kleij D, Latz E, Brouwers JF, Kruize YC, Schmitz M, Kurt-Jones EA, et al. (2002). "A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization". J Biol Chem. 277 (50): 48122–9. doi:10.1074/jbc.M206941200. PMID 12359728.
^ ^a ^b Shinjo Y, Makide K, Satoh K, Fukami F, Inoue A, Kano K, et al. (2017). "Lysophosphatidylserine suppresses IL-2 production in CD4 T cells through LPS3/GPR174". Biochem Biophys Res Commun. 494 (1–2): 332–338. doi:10.1016/j.bbrc.2017.10.028. PMID 29017923.
^ Sugo T, Tachimoto H, Chikatsu T, Murakami Y, Kikukawa Y, Sato S, et al. (2006). "Identification of a lysophosphatidylserine receptor on mast cells". Biochem Biophys Res Commun. 341 (4): 1078–87. doi:10.1016/j.bbrc.2006.01.069. PMID 16460680.
^ Park KS, Lee HY, Kim MK, Shin EH, Bae YS (Jul 2005). "Lysophosphatidylserine stimulates leukemic cells but not normal leukocytes". Biochemical and Biophysical Research Communications. 333 (2): 353–8. doi:10.1016/j.bbrc.2005.05.109. PMID 15946646.
^ Yea K, Kim J, Lim S, Kwon T, Park HS, Park KS, Suh PG, Ryu SH (Jan 2009). "Lysophosphatidylserine regulates blood glucose by enhancing glucose transport in myotubes and adipocytes". Biochemical and Biophysical Research Communications. 378 (4): 783–8. doi:10.1016/j.bbrc.2008.11.122. PMID 19063864.

External links

Lysophosphatidylserine at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[pmid12359728-1] van der Kleij D, Latz E, Brouwers JF, Kruize YC, Schmitz M, Kurt-Jones EA, et al. (2002). "A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization". J Biol Chem. 277 (50): 48122–9. doi:10.1074/jbc.M206941200. PMID 12359728.

[pmid29017923-2] Shinjo Y, Makide K, Satoh K, Fukami F, Inoue A, Kano K, et al. (2017). "Lysophosphatidylserine suppresses IL-2 production in CD4 T cells through LPS3/GPR174". Biochem Biophys Res Commun. 494 (1–2): 332–338. doi:10.1016/j.bbrc.2017.10.028. PMID 29017923.

[pmid16460680-3] Sugo T, Tachimoto H, Chikatsu T, Murakami Y, Kikukawa Y, Sato S, et al. (2006). "Identification of a lysophosphatidylserine receptor on mast cells". Biochem Biophys Res Commun. 341 (4): 1078–87. doi:10.1016/j.bbrc.2006.01.069. PMID 16460680.

[pmid15946646-4] Park KS, Lee HY, Kim MK, Shin EH, Bae YS (Jul 2005). "Lysophosphatidylserine stimulates leukemic cells but not normal leukocytes". Biochemical and Biophysical Research Communications. 333 (2): 353–8. doi:10.1016/j.bbrc.2005.05.109. PMID 15946646.

[5] Yea K, Kim J, Lim S, Kwon T, Park HS, Park KS, Suh PG, Ryu SH (Jan 2009). "Lysophosphatidylserine regulates blood glucose by enhancing glucose transport in myotubes and adipocytes". Biochemical and Biophysical Research Communications. 378 (4): 783–8. doi:10.1016/j.bbrc.2008.11.122. PMID 19063864.

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