Ethinylestradiol/megestrol acetate

Ethinylestradiol/megestrol acetate
	Ethinylestradiol
	Megestrol acetate
Combination of
Ethinylestradiol	Estrogen
Megestrol acetate	Progestogen; Progestin
Clinical data
Trade names	Nuvacon, Volidan
Other names	EE/MGA
Routes of; administration	By mouth
Drug class	Estrogen; Progestin; Progestogen
Legal status
Legal status	US: ℞-only;
Identifiers
CAS Number	8064-66-2;
PubChem CID	66446;

Ethinylestradiol/megestrol acetate (EE/MGA), sold under the brand name Volidan among others, was a combination of ethinylestradiol (EE), an estrogen, and megestrol acetate (MGA), a progestin, which was used as a birth control pill to prevent pregnancy in women.^[1]^[2] It was taken by mouth and contained 50 to 100 μg EE and 1 to 5 mg MGA per tablet.^[2]^[1] MGA-containing birth control pills were withdrawn after reports in the early 1970s of a high incidence of venous thromboembolism in association with the preparations.^[3]

References

^ ^a ^b Lara Marks (2001). Sexual Chemistry: A History of the Contraceptive Pill. Yale University Press. pp. 77–78. ISBN 978-0-300-08943-1.
^ ^a ^b Mears E (1963). "A new type of oral contraceptive". Br Med J. 1 (5341): 1318–20. doi:10.1136/bmj.1.5341.1318. PMC 2123904. PMID 13934321.
^ El Makhzangy MN, Wynn V, Lawrence DM (January 1979). "Sex hormone binding globulin capacity as an index of oestrogenicity or androgenicity in women on oral contraceptive steroids". Clinical Endocrinology. 10 (1): 39–45. doi:10.1111/j.1365-2265.1979.tb03031.x. PMID 571314. S2CID 7262495.

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