Proxalutamide
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| Other names | Pruxelutamide; GT-0918 |
| Routes of administration | By mouth |
| Drug class | Nonsteroidal antiandrogen |
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| Formula | C24H19F4N5O2S |
| Molar mass | 517.50 g·mol−1 |
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Proxalutamide (developmental code name GT-0918) is a nonsteroidal antiandrogen (NSAA) – specifically, a selective high-affinity silent antagonist of the androgen receptor (AR) – which is under development by Suzhou Kintor Pharmaceuticals, inc., a subsidiary of Kintor Pharmaceutical Limited, for the potential treatment of COVID-19, prostate cancer, and breast cancer.[1][2][3][4][5] It was approved in Paraguay for the treatment of COVID-19 in July 2021, but has not been approved at this time in other countries.[1]
Research
[edit]Prostate cancer
[edit]Proxalutamide is in phase III studies for mCRPC as monotherapy and in combination with abiraterone. In the United States, it is in phase II study as monotherapy for mCRPC.[6][7]
Other indications
[edit]Proxalutamide is in phase Ic clinical trial in China.[1][8]
See also
[edit]References
[edit]- ^ a b c "Proxalutamide - Suzhou Kintor Pharmaceuticals". AdisInsight. Springer Nature Switzerland AG.
- ^ Tong Y, Chen C, Wu J, Yang J, Zhang H, Wu X, et al. (2014). "Proxalutamide (GT0918), a potent androgen receptor pathway inhibitor". Cancer Research. 74 (19 Supplement): 614. doi:10.1158/1538-7445.AM2014-614. ISSN 0008-5472.
- ^ Tong Y, Chen C, Wu J, Zhang H, Wu X, Duan Y, Gao W, Niu X, Ma L, Guo C (2014). "Discovery of potent androgen receptor antagonists for treating CRPC and AR+ breast cancer". Cancer Research. 73 (8 Supplement): 2460. doi:10.1158/1538-7445.AM2013-2460. ISSN 0008-5472.
- ^ Applied Biology, Inc. (2020-12-29). "Anti-Androgen Treatment for COVID-19".
{{cite journal}}: Cite journal requires|journal=(help) - ^ "EQS-News: Kintor's Proxalutamide (GT0918) COVID-19 Clinical Trial Shows Positive Re-sults in Treatment of Male and Female". Bloomberg.com. 2021-01-11. Retrieved 2021-01-29.
- ^ "Product Pipeline". Kintor Pharmaceutical. Retrieved 2021-01-29.
- ^ Suzhou Kintor Pharmaceutical (2020-03-13). "An Extended/Phase 2, Multi-Center, Randomized, Open-Label Study to Evaluate the Safety and Tolerability of GT0918 in Subjects With Metastatic Castrate Resistant Prostate Cancer (mCRPC) Who Failed Either Abiraterone or Enzalutamide". Clinical Trials. US.
- ^ "Safety, Tolerability, and Pharmacokinetics of Proxalutamide Therapy in Women With Metastatic Breast Cancer". Clinical trials. 24 September 2019. Retrieved 2021-01-29.
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