Linuron
 | |
| Identifiers | |
|---|---|
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.005.779 |
| Chemical and physical data | |
| Formula | C9H10Cl2N2O2 |
| Molar mass | 249.09 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Linuron (3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea) is a phenylurea herbicide[1] that is used to control the growth of grass and weeds for the purpose of supporting the growth of crops like soybeans.[2][3]
Pharmacology
[edit]Mechanism of action
[edit]Linuron acts via inhibition of photosystem II, which is necessary for photosynthetic electron transport in plants.[2][3]
Effects in animals
[edit]Linuron has been found to produce reproductive toxicity in animals by acting as an androgen receptor (AR) antagonist, and for this reason, is considered to be an endocrine disruptor.[2][4] Consequently, in January 2017, the Standing Committee on Plants, Animals, Food and Feed (SCoPAFF) of the European Commission DG "Health and food safety" decided to not renew its regulatory approval.[5] Sales are expected to cease by June 2017.[5]
See also
[edit]References
[edit]- ^ Maier-Bode H, Härtel K (1981). "Linuron and monolinuron". Residue Reviews. Reviews of Environmental Contamination and Toxicology. Vol. 77. pp. 1–364. doi:10.1007/978-1-4612-5874-2_1. ISBN 978-1-4612-5876-6. PMID 7017855.
- ^ a b c Mercurio S (30 August 2016). Understanding Toxicology. Jones & Bartlett Learning. pp. 705–. ISBN 978-1-284-12761-4.
- ^ a b Roberts TR (1998). Metabolic Pathways of Agrochemicals. Royal Society of Chemistry. pp. 744–. ISBN 978-0-85404-494-8.
- ^ "Peer review of the pesticide risk assessment of the active substance linuron". EFSA Journal. 14 (7). July 2016. doi:10.2903/j.efsa.2016.4518.
- ^ a b Curtis M. "Linuron fails to gain renewed approval". fginsight.com. Briefing Media Ltd. Archived from the original on 31 October 2021. Retrieved 24 May 2017.