Prosidol

Prosidol
Clinical data
ATC code	none;
Identifiers
	IUPAC name 1-(2-ethoxyethyl)-4-phenylpiperidin-4-yl propionate;
CAS Number	164231-04-3 ;
PubChem CID	10402849;
ChemSpider	8578287 ;
Chemical and physical data
Formula	C18H27NO3
Molar mass	305.418 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OC2(c1ccccc1)CCN(CCOCC)CC2)CC;
	InChI InChI=1S/C18H27NO3/c1-3-17(20)22-18(16-8-6-5-7-9-16)10-12-19(13-11-18)14-15-21-4-2/h5-9H,3-4,10-15H2,1-2H3 ; Key:IOLPYQBYMPDUNK-UHFFFAOYSA-N ;
	(verify)

Prosidol is an opioid analgesic that is an analogue of prodine. It was originally discovered by J.F. MacFarlan and Co. in the 1950s.^[1] It was further developed in Russia in the 1990s during research into the related drug pethidine.^[2]

Prosidol has seen some clinical use, but is still a relatively new drug and does not yet have an extensive history of use. It produces similar effects to other opioids, such as analgesia and sedation, along with side effects such as nausea, itching, vomiting and respiratory depression which may be harmful or fatal.^[3]^[4]

References

^ US 2960507, "Piperidine compounds"
^ Osipova NA, Novikov GA, Vetsheva MS, Prokhorov BM, Beresnev VA, Loseva NA, Zemskaia SI, Smolina TA (1994). "[First experience in the use of a new Russian narcotic analgesic prosidol in oncology]". Anesteziologiia I Reanimatologiia (in Russian) (4): 53–7. PMID 7802322.
^ Osipova NA (1996). "[The problem of opioid tolerance and dependence during clinical use thereof]". Anesteziologiia I Reanimatologiia (in Russian) (4): 17–21. PMID 8975562.
^ Abuzarova GR (2001). "[Prosidol, an original Russian opioid, in the treatment of pain syndromes]". Anesteziologiia I Reanimatologiia (in Russian) (5): 74–7. PMID 11757313.

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[1] US 2960507, "Piperidine compounds"

[pmid7802322-2] Osipova NA, Novikov GA, Vetsheva MS, Prokhorov BM, Beresnev VA, Loseva NA, Zemskaia SI, Smolina TA (1994). "[First experience in the use of a new Russian narcotic analgesic prosidol in oncology]". Anesteziologiia I Reanimatologiia (in Russian) (4): 53–7. PMID 7802322.

[pmid8975562-3] Osipova NA (1996). "[The problem of opioid tolerance and dependence during clinical use thereof]". Anesteziologiia I Reanimatologiia (in Russian) (4): 17–21. PMID 8975562.

[pmid11757313-4] Abuzarova GR (2001). "[Prosidol, an original Russian opioid, in the treatment of pain syndromes]". Anesteziologiia I Reanimatologiia (in Russian) (5): 74–7. PMID 11757313.

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