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Frizzled-1

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(Redirected from FZD1 (gene))
FZD1
Identifiers
AliasesFZD1, frizzled class receptor 1
External IDsOMIM: 603408; MGI: 1196625; HomoloGene: 20750; GeneCards: FZD1; OMA:FZD1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003505

NM_021457

RefSeq (protein)

NP_003496

NP_067432

Location (UCSC)Chr 7: 91.26 – 91.27 MbChr 5: 4.8 – 4.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Frizzled-1 (Fz-1) is a protein that in humans is encoded by the FZD1 gene.[5][6]

Function

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Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157240Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044674Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Nov 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochemical and Biophysical Research Communications. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
  6. ^ a b "Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)".

Further reading

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[edit]
  • "Frizzled Receptors: FZD1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.