Draft:RU-1205

RU-1205
Identifiers
PubChem CID	4641302;
ChemSpider	3831213;
Chemical and physical data
Formula	C21H21FN4O
Molar mass	364.424 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1COCCN1CCN2C3=CC=CC=C3N4C2=NC(=C4)C5=CC=C(C=C5)F;

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Instructions · What links here · RU-1205 (talk: + · bio) · (log) · Copyvios report · reFill · Citation Bot · (Search: Google, Wikipedia) · Submitted 2 days ago by Mo18ekula (talk: D · +) · Last edited 38 hours ago by Jimfbleak

RU-1205 is a kappa opioid receptor (KOR) agonist with analgesic utility in treatment of pain. It was six times the potency of butorphanol.^[1]

RU-1205 substance has high bioavailability (44.17 and 56.03% upon peroral and subcutaneous introduction).^[2]

Granulated RU-1205 produced maximum analgesic effect (138.8% relative to control) within 4-h investigation and retained higher analgesic activity compared to that of parent substance (on the average by 58%, p < 0.05) up to 12 h.^[3]

It is established that this compound does not cause side effects typical of morphine and butorphanol including the development of withdrawal syndrome upon naloxone provocation and tolerance to analgesic activity upon 14-day administration.^[4]

References

^ Spasov AA, Grechko OIu, Shtareva DM, Anisimova VA. [Analgesic properties of morpholinoethylimidazobenzimidazole derivative RU-1205]. Eksp Klin Farmakol. 2013;76(9):15-8. Russian. PMID: 24432563.
^ Spasov AA, Smirnova LA, Rashchenko AI, Kuznetsov KA, Anisimova VA. [The absolute bioavailability of benzimidazole derivative RU-1205 in rats]. Eksp Klin Farmakol. 2014;77(1):17-9. Russian. PMID: 24649597.
^ Spasov AA, Smirnova LA, Grechko OIu, Rashchenko AI, Shtareva DM, Anisimova VA. [Pharmacokinetic and analgesic properties of tabletized dosage form of RU-1205-new imidazobenzimidazole derivative with kappa agonist activity]. Eksp Klin Farmakol. 2014;77(7):27-30. Russian. PMID: 25322651.
^ Grechko OY, Shtareva DM, Spasov AA, Litvinov LA, Rashchenko AI. STUDYING THE PHYSICAL DEPENDENCE ON AND TOLERANCE TO THE ANTINOCICEPTIVE EFFECT OF RU-1205 SUBSTANCE. Eksp Klin Farmakol. 2016 Aug;79(4):8-11. English, Russian. PMID: 29949697.

[1] Spasov AA, Grechko OIu, Shtareva DM, Anisimova VA. [Analgesic properties of morpholinoethylimidazobenzimidazole derivative RU-1205]. Eksp Klin Farmakol. 2013;76(9):15-8. Russian. PMID: 24432563.

[2] Spasov AA, Smirnova LA, Rashchenko AI, Kuznetsov KA, Anisimova VA. [The absolute bioavailability of benzimidazole derivative RU-1205 in rats]. Eksp Klin Farmakol. 2014;77(1):17-9. Russian. PMID: 24649597.

[3] Spasov AA, Smirnova LA, Grechko OIu, Rashchenko AI, Shtareva DM, Anisimova VA. [Pharmacokinetic and analgesic properties of tabletized dosage form of RU-1205-new imidazobenzimidazole derivative with kappa agonist activity]. Eksp Klin Farmakol. 2014;77(7):27-30. Russian. PMID: 25322651.

[4] Grechko OY, Shtareva DM, Spasov AA, Litvinov LA, Rashchenko AI. STUDYING THE PHYSICAL DEPENDENCE ON AND TOLERANCE TO THE ANTINOCICEPTIVE EFFECT OF RU-1205 SUBSTANCE. Eksp Klin Farmakol. 2016 Aug;79(4):8-11. English, Russian. PMID: 29949697.

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See also

References