Draft:Gimantan
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| Clinical data | |
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| Other names | Hemantane, Himantane, A-7. |
| Identifiers | |
| PubChem CID | |
| ChemSpider | |
| Chemical and physical data | |
| Formula | C16H27N |
| Molar mass | 233.399 g·mol−1 |
| 3D model (JSmol) | |
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Gimantan (Hemantane) is a Russian monoamine oxidase inhibitor. It has an adamantane amine molecular structure and is similar to related agents such as amantadine and memantine.
It is patented for the treatment of pain and inflammation,[1] alcoholism:[2] Cerebral circulation:[3] and Parkinson’s disease.[4]
The dosage is standardized to 50mg Tablets:[5]
Synthesis
[edit]Gimantan is synthesized, according to the Leuckart reaction, by heating adamantan-2-one and hexamethyleneimine in the presence of formic acid.[6][7][8]
References
[edit]- ^ Елена Артуровна Вальдман, RU2559777C2 (2014).
- ^ RU2582966C2
- ^ RU2554502C2
- ^ RU2423981C2
- ^ Tsvetkova, E. A.; Volkova, M. Yu.; Stepanenko, O. B.; Kislyak, N. A.; Shcherbakova, O. V.; Avdyunina, N. I.; Pyatin, B. M. (2002). Pharmaceutical Chemistry Journal. 36 (1): 48–50. doi:10.1023/A:1015761110991.
- ^ Sergeeva, M. S.; Grushevskaya, L. N.; Pyatin, B. M.; Avdyunina, N. I.; Gaevaya, L. M.; Klumova, V. S.; Dudenkova, M. E.; Alekseev, K. V.; Litvin, E. A. (2011). "Pharmaceutical analysis and standardization of gimantan parenteral dosage form". Pharmaceutical Chemistry Journal. 45 (8): 499–502. doi:10.1007/s11094-011-0664-1.
- ^ , SU1825499 “N-(2-adamantyl)hexamethyleneimine hydrochloride with anticataleptic activity” [in Russian], S. B. Seredenin, T. A. Voronina, N. I. Avdyunina, et al.,; Byull. Izobret., No. 4 (2010).
- ^ Tsvetkova, E. A.; Volkova, M. Yu.; Stepanenko, O. B.; Avdyunina, N. I.; Bol'shakova, R. F.; Pyatin, B. M. (2001). Pharmaceutical Chemistry Journal. 35 (11): 635–638. doi:10.1023/A:1015158213734.
Category:Adamantanes
Category:Amines
Category:Antidementia agents
Category:Antiparkinsonian agents