Draft:GR-45809

GR-45809
Identifiers
PubChem CID	9955378;
ChemSpider	8130988;
Chemical and physical data
Formula	C20H26Cl2N2O3
Molar mass	413.34 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CCN(C1)CC2CC3(CCN2C(=O)CC4=CC(=C(C=C4)Cl)Cl)OCCO3;

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Instructions · What links here · GR-45809 (talk: + · bio) · (log) · Copyvios report · reFill · Citation Bot · (Search: Google, Wikipedia) · Submitted 2 days ago by Mo18ekula (talk: D · +) · Last edited 30 hours ago by Boghog

GR-45809 is a kappa opioid receptor (KOR) agonist with use in the treatment of pain.^[1]^[2] It was developed over 30 years ago. It has a structure that is similar to ZT-52656A.

References

^ Vecchietti V, Giordani A, Giardina G, Colle R, Clarke GD (January 1991). "(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics". Journal of Medicinal Chemistry. 34 (1): 397–403. doi:10.1021/jm00105a061. PMID 1846921.
^ Scopes DI, Hayes NF, Bays DE, Belton D, Brain J, Brown DS, Judd DB, McElroy AB, Meerholz CA, Naylor A (February 1992). "New kappa-receptor agonists based upon a 2-[(alkylamino)methyl]piperidine nucleus". Journal of Medicinal Chemistry. 35 (3): 490–501. doi:10.1021/jm00081a009. PMID 1310743.

[pmid1846921-1] Vecchietti V, Giordani A, Giardina G, Colle R, Clarke GD (January 1991). "(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics". Journal of Medicinal Chemistry. 34 (1): 397–403. doi:10.1021/jm00105a061. PMID 1846921.

[pmid1310743-2] Scopes DI, Hayes NF, Bays DE, Belton D, Brain J, Brown DS, Judd DB, McElroy AB, Meerholz CA, Naylor A (February 1992). "New kappa-receptor agonists based upon a 2-[(alkylamino)methyl]piperidine nucleus". Journal of Medicinal Chemistry. 35 (3): 490–501. doi:10.1021/jm00081a009. PMID 1310743.

[1]

[2]