4-Chloroisobutyrylfentanyl

4-Chloroisobutyrylfentanyl
Legal status
Legal status	US: Schedule I; Illegal in Finland and Sweden;
Identifiers
	IUPAC name 2-Methyl-N-(4-chlorophenyl)-N-[1-(1-phenylpropan-2-yl)piperidin-4-yl]propanamide;
CAS Number	244195-34-4;
PubChem CID	100974915;
UNII	6DS2GH6V2D;
Chemical and physical data
Formula	C23H29ClN2O
Molar mass	384.95 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c3ccccc3CCN(CC1)CCC1N(C(=O)C(C)C)c(cc2)ccc2Cl;
	InChI InChI=InChI=1S/C23H29ClN2O/c1-18(2)23(27)26(21-10-8-20(24)9-11-21)22-13-16-25(17-14-22)15-12-19-6-4-3-5-7-19/h3-11,18,22H,12-17H2,1-2H3; Key:YWHLYGSHOQKCJG-UHFFFAOYSA-N;

4-Chloroisobutyrylfentanyl (para-Chloroisobutyrylfentanyl, 4-Cl-iBF) is an opioid analgesic that is an analog of fentanyl,^[1] and has been sold online as a designer drug.^[2]^[3]

Side effects

Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.^[4] A new wave of fentanyl analogues and associated deaths began in around 2014 in the US, and have continued to grow in prevalence; especially since 2016 these drugs have been responsible for hundreds of overdose deaths every week.^[5]

Legal status

para-Chloroisobutyrylfentanyl has been a Schedule I controlled drug in the United States since 1 February 2018.^[6] It was banned in Finland in September 2017,^[7] and in Sweden in October 2017.^[8]

References

^ Ohta H, Suzuki S, Ogasawara K (1999). "Studies on fentanyl and related compounds IV. Chromatographic and spectrometric discrimination of fentanyl and its derivatives". Journal of Analytical Toxicology. 23 (4): 280–285. doi:10.1093/jat/23.4.280. PMID 10445491.
^ Furanylfentanyl. Report on the risk assessment of N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]furan-2-carboxamide (furanylfentanyl) in the framework of the Council Decision on new psychoactive substances. EMCDDA Risk Assessments, 2017
^ "Recent Deaths Possibly Linked to Fentanyl". UK National Crime Agency. April 2017. Archived from the original on 2017-11-03. Retrieved 2018-02-03.
^ Mounteney J, Giraudon I, Denissov G, Griffiths P (July 2015). "Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe". The International Journal on Drug Policy. 26 (7): 626–631. doi:10.1016/j.drugpo.2015.04.003. PMID 25976511.
^ Armenian P, Vo KT, Barr-Walker J, Lynch KL (May 2018). "Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review". Neuropharmacology. 134 (Pt A): 121–132. doi:10.1016/j.neuropharm.2017.10.016. PMID 29042317. S2CID 21404877.
^ "Schedules of Controlled Substances: Temporary Placement of Seven Fentanyl-Related Substances in Schedule I". Federal Register. 1 February 2018.
^ "Notification detail. Government Decree amending Annex IV to the Government Decree on substances, preparations and plants to be classified as narcotics The following 9 new substances are classified: 4-chloro-isobutyrfentanyl, 4-Fluoro-isobutyrfentanyl, 3-phenylpropanoylfentanyl, benzodioxole fentanyl, benzoyl fentanyl, cyclopentyl fentanyl, cyclopropyl fentanyl, methoxyacetyl fentanyl and tetramethylcyclopropyane fentanyl". European Commission. 12 September 2017.
^ "14 nya ämnen kan klassas som narkotika eller hälsofarlig vara". The Public Health Agency of Sweden. 14 October 2017.

[1] Ohta H, Suzuki S, Ogasawara K (1999). "Studies on fentanyl and related compounds IV. Chromatographic and spectrometric discrimination of fentanyl and its derivatives". Journal of Analytical Toxicology. 23 (4): 280–285. doi:10.1093/jat/23.4.280. PMID 10445491.

[2] Furanylfentanyl. Report on the risk assessment of N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]furan-2-carboxamide (furanylfentanyl) in the framework of the Council Decision on new psychoactive substances. EMCDDA Risk Assessments, 2017

[3] "Recent Deaths Possibly Linked to Fentanyl". UK National Crime Agency. April 2017. Archived from the original on 2017-11-03. Retrieved 2018-02-03.

[4] Mounteney J, Giraudon I, Denissov G, Griffiths P (July 2015). "Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe". The International Journal on Drug Policy. 26 (7): 626–631. doi:10.1016/j.drugpo.2015.04.003. PMID 25976511.

[pmid29042317-5] Armenian P, Vo KT, Barr-Walker J, Lynch KL (May 2018). "Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review". Neuropharmacology. 134 (Pt A): 121–132. doi:10.1016/j.neuropharm.2017.10.016. PMID 29042317. S2CID 21404877.

[6] "Schedules of Controlled Substances: Temporary Placement of Seven Fentanyl-Related Substances in Schedule I". Federal Register. 1 February 2018.

[7] "Notification detail. Government Decree amending Annex IV to the Government Decree on substances, preparations and plants to be classified as narcotics The following 9 new substances are classified: 4-chloro-isobutyrfentanyl, 4-Fluoro-isobutyrfentanyl, 3-phenylpropanoylfentanyl, benzodioxole fentanyl, benzoyl fentanyl, cyclopentyl fentanyl, cyclopropyl fentanyl, methoxyacetyl fentanyl and tetramethylcyclopropyane fentanyl". European Commission. 12 September 2017.

[8] "14 nya ämnen kan klassas som narkotika eller hälsofarlig vara". The Public Health Agency of Sweden. 14 October 2017.

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Side effects

Legal status

See also

References