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List of investigational antidepressants

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This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources.

This is a list of investigational antidepressants, or drugs that are currently under development for clinical use in the treatment of depression but are not yet approved. Specific indications include major depressive disorder, treatment-resistant depression, dysthymia, bipolar depression, and postpartum depression, among others.

Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

This list was last comprehensively updated in August 2024. It is likely to become outdated with time.

Under development

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Preregistration

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  • Buprenorphine/samidorphan (ALKS-5461) – μ-opioid receptor partial agonist, κ-opioid receptor antagonist, δ-opioid receptor antagonist, and μ-opioid receptor antagonist combination – New Drug Application (NDA) rejected in 2019, no updates since 2021 [1][2]

Phase 3

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  • Aticaprant (AVTX-501; CERC-501; JNJ-3964; JNJ-67953964; LY-2456302) – κ-opioid receptor antagonist [3]
  • CYB003 (CYB-003; deuterated psilocybin analogue) – serotonin 5-HT2A receptor agonist and psychedelic hallucinogen [4][5][6][7]
  • Cycloserine/lurasidone (Cyclurad; NRX-101) – ionotropic glutamate NMDA receptor glycine site partial agonist and atypical antipsychotic (non-selective monoamine receptor modulator) combination [8]
  • Esmethadone (dextromethadone; REL-1017) – ionotropic glutamate NMDA receptor antagonist and other actions [9]
  • Ketamine (HTX-100; NRX-100) – ionotropic glutamate NMDA receptor antagonist [10]
  • Navacaprant (BTRX-140; BTRX-335140; CYM-53093; NMRA-140; NMRA-335140) – κ-opioid receptor antagonist [11]
  • Pimavanserin (ACP-103; BVF-048; Nuplazid) – serotonin 5-HT2A receptor antagonist or inverse agonist [12]
  • Psilocybin (COMP-360) – non-selective serotonin receptor agonist and psychedelic hallucinogen [13][14]
  • Seltorexant (JNJ-42847922; JNJ-7922; MIN-202) – orexin OX2 receptor antagonist [15]
  • SEP-4199 (non-racemic amisulpride; aramisulpride/esamisulpride [85:15 ratio]) – atypical antipsychotic (dopamine D2 and D3 receptor antagonist and serotonin 5-HT2B and 5-HT7 receptor antagonist) [16]
  • SNG-12 (Synapsinae) – glycine transporter 1 (GlyT1) inhibitor [17]
  • Solriamfetol (Sunosi; JZP-110; SKLN05; ARL-N05; YKP-10A; R-228060; ADX-N05) – norepinephrine and dopamine reuptake inhibitor and trace amine-associated receptor 1 (TAAR1) agonist [18][19][20]
  • Ulotaront (SEP-363856; SEP-856) – serotonin 5-HT1A receptor agonist and trace amine-associated receptor 1 (TAAR1) agonist [21]

Phase 2/3

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  • PRAX-114 – extrasynaptic GABAA receptor-preferring positive allosteric modulator and neurosteroid [22]

Phase 2

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  • 4-Chlorokynurenine (4-CL-KYN; AV-101) – ionotropic glutamate NMDA receptor glycine site antagonist and kynurenine modulator [23]
  • Ademetionine (MSI-190; MSI-195; S-Adenosyl-L-Methionine; Sam-E; SAMe; Strada) – cofactor in monoamine neurotransmitter biosynthesis [24]
  • ALTO-100 (NSI-189) – unknown mechanism of action (hippocampal neurogenesis stimulant and indirect brain-derived neurotrophic factor (BDNF) modulator) [25] [26]
  • ALTO-203 – histamine H3 receptor agonist [27]
  • Apimostinel (AGN-241660; GATE-202; NRX-1074) – ionotropic glutamate NMDA receptor glycine site partial agonist [28]
  • Arketamine ((R)-ketamine; PCN-101) – ionotropic glutamate NMDA receptor antagonist [29]
  • Azetukalner (1OP-2198; Encukalner; VRX-621698; XEN-1101; XPF-008) – KCNQ potassium channel agonist [30]
  • BHV-7000 (BPN-25203; KB-3061) – KCNQ2 potassium channel stimulant [31]
  • BI-1358894 – transient receptor potential cation TRPC4 and TRPC5 channel inhibitor [32][33]
  • Brezivaptan (ANC-501; THY-1773; TS-1211; TS-121) – vasopressin V1b receptor antagonist [34]
  • Centanafadine (CTN; EB-1020) – serotonin, norepinephrine, and dopamine reuptake inhibitor [35]
  • Deudextromethorphan/quinidine (AVP-786; CTP-786; d-DM/Q; d6-DM/Q; deuterated dextromethorphan/ultra-low-dose quinidine) – sigma σ1 receptor agonist, serotonin reuptake inhibitor, ionotropic glutamate NMDA receptor antagonist, other actions, and CYP2D6 inhibitor combination [36]
  • Dimethyltryptamine (N,N-Dimethyltryptamine; DMT; N,N-DMT; BMND-01; BMND-02; BMND-03) – non-selective serotonin receptor agonist and psychedelic hallucinogen [37]
  • Emestedastat (UE-2343; Xanamem) – 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor (glucocorticoid synthesis inhibitor) [38]
  • Esketamine (CLE-100) – ionotropic glutamate NMDA receptor antagonist [39]
  • FKB-01MD (FKB01MD; TGBA-01AD; TGBA01AD) – serotonin reuptake inhibitor, serotonin 5-HT1A receptor agonist, serotonin 5-HT1D receptor modulator, and serotonin 5-HT2 receptor agonist [40]
  • GM-1020 – ionotropic glutamate NMDA receptor antagonist [41][42]
  • GM-2505 – serotonin 5-HT2A and 5-HT2C receptor agonist, psychedelic hallucinogen, and serotonin releasing agent [43]
  • Itruvone (PH-10; PH-10A; PH10-NS) – chemoreceptor cell stimulant, vomeropherine, and neurosteroid [44]
  • JNJ-54175446 (JNJ-5446) – purinergic P2X7 receptor antagonist [45]
  • JNJ-55308942 – purinergic P2X7 receptor antagonist [46]
  • Ketamine (extended-release; R-107; R107) – ionotropic glutamate NMDA receptor antagonist [47]
  • Ketamine (intranasal; Ereska; PMI-100; PMI-150; SLS-002; TUR-002) – ionotropic glutamate NMDA receptor antagonist [48]
  • Ketamine (prolonged-release oral; KET-01) – ionotropic glutamate NMDA receptor antagonist [49]
  • Liafensine (BMS-820836; DB-104) – serotonin, norepinephrine, and dopamine reuptake inhibitor [50]
  • Lisdexamfetamine (Vyvanse) – norepinephrine and dopamine releasing agent [51]
  • Lysergic acid diethylamide (LSD; MB-22001) – non-selective serotonin receptor agonist and psychedelic hallucinogen [52]
  • Mebufotenin (5-MeO-DMT; 5-Methoxy-N,N-Dimethyltryptamine; BPL-002; BPL-003) – non-selective serotonin receptor agonist and psychedelic hallucinogen [53]
  • Mifepristone (Mifeprex; RU-38486; RU-486) – progesterone receptor antagonist, glucocorticoid receptor antagonist, and androgen receptor antagonist [54]
  • NBI-1070770 – NR2B subunit-containing ionotropic glutamate NMDA receptor negative allosteric modulator [55]
  • NORA-520 (brexanolone prodrug) – GABAA receptor positive allosteric modulator and neurosteroid [56]
  • Onabotulinum toxin A (BoNTA; Botox; Botulinum toxin A injectable; GSK-1358820; OnabotA X; onabotulinumtoxinA X; Vistabel; Vistabex) – acetylcholine release inhibitor and neuromuscular blocking agent [57]
  • Onfasprodil (CAD-9271; MIJ-821; MIJ821) – NR2B subunit-containing ionotropic glutamate NMDA receptor negative allosteric modulator [58]
  • OPC-64005 – serotonin, norepinephrine, and dopamine reuptake inhibitor [59]
  • Osavampator (TAK-653; NBI-1065845; NBI-845) – ionotropic glutamate AMPA receptor positive allosteric modulator [60]
  • OSU-6162 (PNU-9639; PNU-96391; PNU-96391A) – serotonin 5-HT2A receptor partial agonist (non-hallucinogenic), dopamine D2 receptor partial agonist, and sigma σ1 receptor ligand (so-called "monoaminergic stabilizer") [61][62][63][64][65][66][67]
  • PDC-1421 (ABV-1504; ABV-1505; ABV-1601; BLI-1005) – norepinephrine reuptake inhibitor [68]
  • Pegipanermin (DN-TNF; INB-03; LIVNate; Quellor; XENP-1595; XENP-345; XPro-1595; XPro595; XPro) – tumor necrosis factor α (TNFα) inhibitor [69]
  • Pramipexole (CTC-413; CTC-501) – dopamine D2, D3, and D4 receptor agonist [70]
  • Pregnenolone methyl ether (3β-methoxypregnenolone; MAP-4343) – microtubule-associated protein (MAP) stimulant and tubulin polymerization promoter [71]
  • Ralmitaront (RG-7906; RO-6889450) – trace amine-associated receptor 1 (TAAR1) agonist [72]
  • RE-104 (FT-104; 4-HO-DiPT/iprocin prodrug) – serotonin 5-HT2A receptor agonist and psychedelic hallucinogen [73]
  • Rislenemdaz (AVTX-301; CERC-301; MK-0657) – NR2B subunit-containing ionotropic glutamate NMDA receptor negative allosteric modulator [74]
  • Ropanicant (SUVN-911) – α4β2 nicotinic acetylcholine receptor antagonist [75]
  • SP-624 – sirtuin 6 (SIRT6) stimulant [76]
  • SPN-820 (NV-5138; SPN-821) – sestrin2 modulator and mammalian target of rapamycin complex 1 (mTORC1) stimulant [77]
  • Tebideutorexant (JNJ-61393215; JNJ-3215) – orexin OX1 receptor antagonist [78]
  • Tildacerfont (SPR-001; LY-2371712) – corticotropin releasing factor receptor 1 (CRF1) antagonist [79]
  • Tramadol (controlled-release; ETS-6103; ETX-6103; Viotra) – μ-opioid receptor agonist, serotonin and norepinephrine reuptake inhibitor, serotonin 5-HT2C receptor antagonist, and other actions [80]
  • TS-161 – metabotropic glutamate mGlu2 and mGlu3 receptor antagonist [81]
  • Zelquistinel (AGN-241751; GATE-251) – ionotropic glutamate NMDA receptor partial positive allosteric modulator [82]

Phase 1/2

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  • PT-00114 (PT100114) – corticotropin releasing hormone (CRH) inhibitor [83]

Phase 1

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  • ABX-002 (LL-340001 prodrug) – thyroid hormone receptor β (TRβ) agonist [84][85]
  • Agomelatine (ALTO-300; agomelatine 25 mg formulation) – serotonin 5-HT2C receptor antagonist and melatonin MT1 and MT2 receptor agonist [84][86]
  • BI-1569912 – NR2B subunit-containing ionotropic glutamate NMDA receptor negative allosteric modulator [87]
  • BRII-296 (extended-release injectable aqueous suspension formulation of brexanolone) – GABAA receptor positive allosteric modulator and neurosteroid [87][88]
  • Brilaroxazine (RP-5000; RP-5063) – atypical antipsychotic (non-selective monoamine receptor modulator) [89]
  • Carbidopa/oxitriptan (EVX-101) – serotonin precursor (5-hydroxytryptophan; 5-HTP) and aromatic L-amino acid decarboxylase (AAAD) inhibitor combination [90]
  • Crisdesalazine (AAD-2004) – microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor [91]
  • DGX-001 – gut–brain axis modulator [92][93]
  • Dimethyltryptamine (N,N-dimethyltryptamine; DMT; N,N-DMT; VLS-01) – non-selective serotonin receptor agonist and psychedelic hallucinogen [94]
  • DLX-001 (DLX-1; AAZ; AAZ-A-154) – non-hallucinogenic serotonin 5-HT2A receptor agonist [95][96]
  • DSP-3456 – metabotropic glutamate mGlu2 and mGlu3 receptor negative allosteric modulator [92]
  • Ebselen (DR-3305; Harmokisane; PZ-51; SPI-1005; SPI-3005) – multiple mechanisms of action [97]
  • Icalcaprant (CVL-354) – κ-opioid receptor antagonist [98]
  • KAR-2618 (GFB-887) – transient receptor potential cation TRPC4 and TRPC5 channel inhibitor [99]
  • PIPE-307 – muscarinic acetylcholine M1 receptor antagonist [100]
  • SAL-0114 – undefined mechanism of action [101]
  • Scopolamine (DPI-385-CVS; DPI-386; DPI-386 Nasal Gel; DPI-386-SG; DPI-386-SS; DPI-387; DPI-521-CG; DPI-550-TBI; INSCOP spray) – non-selective muscarinic acetylcholine receptor antagonist [102]
  • Traneurocin (NA-831; Cycloprolylglycine; CPG) – unknown or undefined / ionotropic glutamate AMPA receptor positive allosteric modulator, GABAA receptor positive allosteric modulator, and racetam-like drug [103]
  • XW-10508 (oral esketamine conjugate prodrug) – ionotropic glutamate NMDA receptor antagonist [104]

Preclinical

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  • 2-Bromo-LSD (bromolysergide; BETR-001, TD-0148A) – non-hallucinogenic serotonin 5-HT2A receptor agonist and other actions[105][106][107]
  • ACD856 (ACD-856) – tropomyosin receptor kinase TrkA, TrkB, and TrkC positive allosteric modulator [108][109]
  • ALTO-202 – NR2B subunit-containing ionotropic glutamate NMDA receptor antagonist [110]
  • Brexpiprazole (long-acting injectable; MTD-211) – atypical antipsychotic (non-selective monoamine receptor modulator) [111]
  • CB-03 (CB-04; CB-003; CB03-154) – KCNQ2 and KCNQ3 potassium channel stimulant [112]
  • CRHR1 antagonist therapeutic (HMNC Brain Health) – corticotropin releasing factor receptor 1 (CRF1) antagonist [113]
  • Duloxetine (oral suspension) – serotonin and norepinephrine reuptake inhibitor [114]
  • ENX-104 – presynaptic dopamine D2 and D3 autoreceptor antagonist (at low doses) [115] [116][117][118]
  • ENX-105 – dopamine D2 and D3 receptor antagonist and serotonin 5-HT1A and 5-HT2A receptor agonist (non-hallucinogenic) [119][117][118]
  • Etifoxine deuterated (GRX-917) – GABAA receptor positive allosteric modulator and translocator protein (TSPO; peripheral benzodiazepine receptor) agonist (neurosteroidogenesis stimulant) [120]
  • GABA positive allosteric modulator (CS Bay Therapeutics) – GABAA receptor positive allosteric modulator [121]
  • INV-88 – macrophage migration inhibitory factor (MIF) inhibitor [122]
  • ITI-333 – serotonin 5-HT2A receptor antagonist, μ-opioid receptor biased partial agonist, α1A-adrenergic receptor antagonist, and dopamine D1 receptor antagonist [123]
  • ITI-1549 – non-hallucinogenic serotonin 5-HT2A receptor agonist and serotonin 5-HT2B receptor antagonist[124][125][126]
  • Ketamine (depot; ALA-3000) – ionotropic glutamate NMDA receptor antagonist [127]
  • Lithium cocrystal (AL-001; LiProSal; lithium salicylate L-proline ionic cocrystal) – unknown mechanism of action and mood stabilizer (improved formulation of lithium) [128]
  • LPH-5 – selective serotonin 5-HT2A receptor partial agonist and psychedelic hallucinogen [129][130][131]
  • LPCN-1154 (LPCN1154; oral brexanolone) – GABAA receptor positive allosteric modulator and neurosteroid [132][133]
  • Lucid-PSYCH (Lucid-201) – undefined mechanism of action and psychedelic hallucinogen [134][135][136][137]
  • Mebufotenin (5-MeO-DMT; 5-methoxy-N,N-dimethyltryptamine; LSR-1019) – non-selective serotonin receptor agonist and psychedelic hallucinogen [138]
  • Midomafetamine (microneedle transdermal patch; 3,4-methylenedioxymethamphetamine; MDMA) – serotonin, norepinephrine, and dopamine releasing agent and weak serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor agonist (entactogen and weak psychedelic hallucinogen) [139]
  • Nezavist – GABAA receptor positive allosteric modulator [140]
  • NLX-101 (F-15599) – serotonin 5-HT1A receptor full agonist [141]
  • PSIL-001 (DMT analogue) – serotonin 5-HT1 receptor modulator (non-hallucinogenic) [142][143]
  • PSIL-002 (DMT analogue) – serotonin 5-HT1 receptor modulator (non-hallucinogenic) [144][143][145]
  • Psylo-4001 – serotonin 5-HT2A receptor agonist and psychedelic hallucinogen [146][147]
  • SYT-510 – endocannabinoid reuptake inhibitor [148]
  • TF-0066 – undefined mechanism of action [149]

Research

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  • BHV-5000 – low-trapping ionotropic glutamate NMDA receptor antagonist [150]
  • NP-10679 – NR2B subunit-containing ionotropic glutamate NMDA receptor negative allosteric modulator [151]
  • Psilocybin (MYCO-001; MYCO-003) – non-selective serotonin receptor agonist and psychedelic hallucinogen [152]
  • Small molecule therapeutic - Rugen Therapeutics – undefined mechanism of action [153]


Phase unknown

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  • Amuxetine – serotonin, norepinephrine, and dopamine reuptake inhibitor [154][155]
  • EDG-005 – undefined mechanism of action [156]
  • EDG-006 – undefined mechanism of action [157]
  • Iloperidone (Fanapt; Fanaptum; Fiapta; HP-873; ILO-522; VYV-683; Zomaril) – atypical antipsychotic (non-selective monoamine receptor modulator) [158]
  • INV-407 – undefined mechanism of action [159]
  • Ketamine (intravenous/oral; Braxia) – ionotropic glutamate NMDA receptor antagonist [160]
  • SK-2110 (buprenorphine implant) – μ-opioid receptor partial agonist, κ-opioid receptor antagonist, and δ-opioid receptor antagonist – under development in China [161][162]
  • Venlafaxine (controlled-release) – serotonin and norepinephrine reuptake inhibitor [163]


Not under development

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Development suspended

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  • BVF-045 (bupropion/undisclosed serotonin reuptake inhibitor) – norepinephrine and dopamine reuptake inhibitor, nicotinic acetylcholine receptor negative allosteric modulator, and serotonin reuptake inhibitor combination [164] [165] [166]
  • Dexmedetomidine (BXCL-501; Igalmi; KalmPen) – α2-adrenergic receptor agonist [167]
  • ETX-155 – GABAA receptor positive allosteric modulator [168]
  • Ganaxolone (CCD-1042; Ztalmy) – GABAA receptor positive allosteric modulator and neurosteroid [169]

No development reported

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  • AAG-561 – corticotropin releasing hormone (CRH) inhibitor [170]
  • Adinazolam (Deracyn; U-41123; U-41123F) – GABAA receptor positive allosteric modulator and benzodiazepine [171]
  • Amitifadine (DOV-21947; EB-1010) – serotonin, norepinephrine, and dopamine reuptake inhibitor [172]
  • AN-788 (NSD-788) – serotonin and dopamine reuptake inhibitor [173]
  • ANAVEX 1-41 (blarcamesine analogue) – sigma σ1 receptor agonist, muscarinic acetylcholine receptor modulator, and sodium and chloride channel modulator [174]
  • Aripiprazole (transdermal; AQS-1301) – atypical antipsychotic (non-selective monoamine receptor modulator) [175]
  • Arketamine (HR-071603; (R)-ketamine nasal spray) – ionotropic glutamate NMDA receptor antagonist [176]
  • AZD-8108 – ionotropic glutamate NMDA receptor antagonist [177]
  • BCI-632 – metabotropic glutamate mGlu2 and mGlu3 receptor antagonist [178]
  • BCI-838 – metabotropic glutamate mGlu2 and mGlu3 receptor antagonist [179]
  • BMS-866949 (CSTI-500) – serotonin, norepinephrine, and dopamine reuptake inhibitor [180]
  • BNC-210 (IW-2143) – α7 nicotinic acetylcholine receptor negative allosteric modulator [181]
  • Bryostatin 1 (MW-904) – protein kinase C (PKC) stimulant [182]
  • BTRX-246040 (LY-2940094) – nociceptin receptor antagonist [183]
  • Bupropion/naltrexone (Contrave) – norepinephrine and dopamine reuptake inhibitor, nicotinic acetylcholine receptor negative allosteric modulator, and μ-opioid receptor antagonist combination [184]
  • Cericlamine (JO-1017) – serotonin reuptake inhibitor [185]
  • Citalopram/pipamperone (PipCit; PNB-01) – serotonin reuptake inhibitor and typical antipsychotic combination [186]
  • Depression therapy - Genopia Biomedical – undefined mechanism of action [187]
  • (R)-Desmethylsibutramine ((+)-desmethylsibutramine; or (R)-desmethylsibutramine/(+)-didesmethylsibutramine) – serotonin, norepinephrine, and dopamine reuptake inhibitor [188]
  • Dipraglurant (ADX-48621; mGluR5-NAM) – metabotropic glutamate mGlu5 receptor negative allosteric modulator [189]
  • Erteberel (LY-500307; SERBA-1) – estrogen receptor β (ERβ) agonist [190]
  • Esketamine (esketamine DPI; Falkieri; PG061; S-ketamine) – ionotropic glutamate NMDA receptor antagonist [191]
  • Eszopiclone (Lunesta) – GABAA receptor positive allosteric modulator and Z-drug [192]
  • EVT-101 (ENS-101) – NR2B subunit-containing ionotropic glutamate NMDA receptor negative allosteric modulator [193]
  • Fananserin (RP-62203) – serotonin 5-HT2A receptor antagonist and dopamine D4 receptor antagonist [194]
  • Fibroblast growth factor 1 (FGF-1) – fibroblast growth factor receptor (FGFR) agonist [195]
  • Filorexant (MK-6096) – orexin OX1 and OX2 receptor antagonist [196]
  • GEA-857 (alaproclate analogue) – potassium conductance putative blocker [197]
  • GSK-588045 – serotonin 5-HT1A, 5-HT1B, and 5-HT1D receptor antagonist [198]
  • GSK-1360707 – serotonin, norepinephrine, and dopamine reuptake inhibitor [199]
  • HS-10353 – GABAA receptor positive allosteric modulator [200][201]
  • Hypidone – serotonin reuptake inhibitor and serotonin 5-HT1A and 5-HT6 receptor agonist [202]
  • Igmesine (CI-1019; JO-1784) – sigma σ1 receptor agonist [203]
  • Imiloxan (RS-21361) – α2-adrenergic receptor antagonist [204]
  • IN-ASTR-001 – undefined mechanism of action [205]
  • Ketamine (transdermal patch; SHX-001) – ionotropic glutamate NMDA receptor antagonist [206]
  • Ketamine (sublingual; ketamine wafer; SLS-003; Wafermine) – ionotropic glutamate NMDA receptor antagonist [207]
  • KFM-19 – adenosine A1 receptor antagonist [208]
  • LSM-6 (3-hydroxy-N,N-dimethylphenethylamine) – undefined mechanism of action (adrenergic and serotonergic agent; constituent of Limacia scanden Lour.) – was under development in Malaysia [209][210]
  • Lumateperone deuterated (ITI-1284) – atypical antipsychotic (non-selective monoamine receptor modulator) [211]
  • Midomafetamine (3,4-methylenedioxymethamphetamine; MDMA; ecstasy) – serotonin, norepinephrine, and dopamine releasing agent and weak serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor agonist (entactogen and weak psychedelic hallucinogen) [212]
  • Mitizodone (HEC-113995) – serotonin reuptake inhibitor and serotonin 5-HT1A and 5-HT1B receptor partial agonist [213][214][215]
  • Nivacortol (nivazole; NEBO-174; novozola) – glucocorticoid receptor antagonist [216]
  • Omiloxetine – serotonin reuptake inhibitor [217]
  • Oxitriptan (5-hydroxytryptophan; 5-HTP; EVX-301) – serotonin precursor [218]
  • Pseudohypericin – undefined mechanism of action (constituent of St John's wort) [219]
  • Psilocybin (CYB-001; INT0052/2020) – non-selective serotonin receptor agonist and psychedelic hallucinogen [220]
  • Psilocybin (biosynthetic psilocybin; PB-1818) – non-selective serotonin receptor agonist and psychedelic hallucinogen [221]
  • QRX-002 – ionotropic glutamate NMDA receptor antagonist [222]
  • RG-7351 – trace amine-associated receptor 1 (TAAR1) agonist [223]
  • Riluzole (sublingual; BHV-0223; Nurtec) – complex mechanism of action or glutamatergic modulator [224]
  • Risperidone (Risperdal) – atypical antipsychotic (non-selective monoamine receptor modulator) [225]
  • SAR-102779 (SAR-10279) – neurokinin NK2 receptor antagonist [226]
  • SD-254 (deuterated venlafaxine) – serotonin and norepinephrine reuptake inhibitor [227]
  • SEP-378614 – undefined mechanism of action [228]
  • SNA-1 – undefined mechanism of action [229]
  • SPL-801-B ((2R,6R)-hydroxynorketamine; 6-HNK) – non-hallucinogenic ketamine derivative/metabolite [230]
  • TrkB receptor antagonist (Celon Pharma) – tropomyosin receptor kinase TrkB antagonist [231]
  • YDP-2225 – undefined mechanism of action [232]


Development discontinued

[edit]
  • ABT-436 – vasopressin V1b receptor antagonist [233]
  • Adatanserin (WAY-SEB-324; WY-50324; SEB-324) – serotonin 5-HT1A receptor partial agonist and serotonin 5-HT2A and 5-HT2C receptor antagonist [234]
  • ADX-71149 (JNJ-1813; JNJ-40411813; JNJ-mGluR2-PAM) – metabotropic glutamate mGlu2 receptor modulator [235]
  • Amesergide (LY-237733) – serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor antagonist, α2-adrenergic receptor antagonist, and other actions [236]
  • Amibegron (SR-58611; SR-58611A) – β3-adrenergic receptor agonist [237]
  • Aprepitant (MK-869) – neurokinin NK1 receptor antagonist[238][239][240]
  • ARA-014418 (AR-A014418; GSK-3β Inhibitor VIII) – glycogen synthase kinase GSK-3β inhibitor [241]
  • Armodafinil (CEP-10953; Nuvigil; (R)-modafinil) – atypical dopamine reuptake inhibitor [242]
  • Atipamezole (antisedan; MPV-1248) – α2-adrenergic receptor antagonist [243]
  • Atomoxetine (LY-139603; Strattera; Tomoxetine) – norepinephrine reuptake inhibitor [244]
  • AZD-2066 – metabotropic glutamate mGlu5 receptor antagonist [245]
  • AZD-2327 – δ-opioid receptor agonist [246]
  • AZD-7268 – δ-opioid receptor agonist [247]
  • AZD-8129 (AR-A000002; AR-A2XX; AR-A2) – serotonin 5-HT1B receptor antagonist [248]
  • Basimglurant (NOE-101; RG-7090; RO-4917523) – metabotropic glutamate mGlu5 receptor antagonist [249]
  • Befloxatone (MD-370503) – monoamine oxidase MAO-A reversible inhibitor [250]
  • BMS-181101 (BMY-42569) – serotonin reuptake inhibitor and serotonin 5-HT1A and 5-HT1D receptor agonist [251]
  • Buspirone (transdermal; BuSpar Patch) – serotonin 5-HT1A receptor partial agonist [252]
  • Casopitant (GW-679769; GW679769) – neurokinin NK1 receptor antagonist[253]
  • Centpropazine – unknown mechanism of action [254][255]
  • Cibinetide (ARA-290) – erythropoietin receptor (EpoR) agonist [256]
  • Citalopram (controlled-release) – serotonin reuptake inhibitor [257]
  • Clavulanic acid (RX-10100; Serdaxin; Zoraxel) – β-lactamase inhibitor and unknown mechanism of action (glutamate transporter GLT1 expression enhancer, dopamine, glutamate, and serotonin modulator, possibly via Munc18-1 and Rab4 interactions) [258][259][260][261][262][263]
  • Clovoxamine (DU-23811) – serotonin and norepinephrine reuptake inhibitor [264]
  • Coluracetam (BCI-540; MKC-231) – ionotropic glutamate AMPA receptor positive allosteric modulator, choline uptake and acetylcholine synthesis enhancer, and racetam [265][266][267][268]
  • CP-316311 – corticotropin releasing hormone (CRH) inhibitor [269]
  • Crinecerfont (NBI-74788; SSR-125543; SSR-125543A) – corticotropin releasing factor receptor 1 (CRF1) antagonist [270]
  • CRL-41789 – undefined mechanism of action [271]
  • Cutamesine (AGY-94806; Msc-1; SA-4503) – sigma σ1 receptor agonist [272]
  • CX157 (KP157; TriRima; Tyrima) – monoamine oxidase MAO-A reversible inhibitor[273]
  • Dapoxetine (LY-210448; Priligy) – serotonin reuptake inhibitor [274]
  • Dasotraline (DSP-225289; SEP-225289; SEP-0225289; SEP-289) – serotonin, norepinephrine, and dopamine reuptake inhibitor [275]
  • DDP-225 – norepinephrine reuptake inhibitor and serotonin 5-HT3 receptor antagonist [276]
  • Decoglurant – metabotropic glutamate mGlu2 and mGlu3 receptor antagonist [277]
  • Delequamine (RS-15385; RS-15385197) – α2-adrenergic receptor antagonist [278]
  • Delucemine (NPS-1506) – ionotropic glutamate NMDA receptor polyamine site antagonist and serotonin reuptake inhibitor [279]
  • Dexmecamylamine (AT-5214; NIH-11008; S-mecamylamine; TC-5214) – α3β4 and α4β2 nicotinic acetylcholine receptor negative allosteric modulator [280]
  • Dexnafenodone (LU-43706) – serotonin and norepinephrine reuptake inhibitor [281]
  • DMP-695 – corticotropin releasing hormone (CRH) inhibitor [282]
  • DOV-216303 – serotonin, norepinephrine, and dopamine reuptake inhibitor [283]
  • DPC-368 – undefined mechanism of action [284]
  • DSP-1200 – serotonin 5-HT2A receptor antagonist, dopamine D2 receptor antagonist, and α2A-adrenergic receptor antagonist [285]
  • Edivoxetine (EDP-125; LY-2216684) – norepinephrine reuptake inhbitor [286]
  • Elzasonan (CP-448187) – serotonin 5-HT1B and 5-HT1D receptor antagonist[287]
  • Emapunil (AC-5216; XBD-173) – translocator protein (TSPO; peripheral benzodiazepine receptor) agonist (neurosteroidogenesis stimulant) [288]
  • Emicerfont (GW-876008; GW-876008X) – corticotropin releasing factor receptor 1 (CRF1) antagonist [289]
  • Eplivanserin (Ciltyri; Sliwens; SR-46349; SR-46349B; SR-46615A) – serotonin 5-HT2A receptor antagonist [290]
  • Eptapirone (F-11440) – serotonin 5-HT1A receptor full agonist [291]
  • Esreboxetine ((S,S)-Reboxetine; AXS-14; PNU-165442G) – norepinephrine reuptake inhibitor [292]
  • Esuprone (LU-43839) – monoamine oxidase MAO-A reversible inhibitor [293]
  • Ethyl eicosapentaenoic acid (Ethyl-EPA) – omega-3 fatty acid [294]
  • Farampator (CX-691; ORG-24448) – ionotropic glutamate AMPA receptor positive allosteric modulator [295]
  • Fasoracetam (AEVI-001; LAM-105; MDGN-001; NFC-1; NS-105) – unknown mechanism of action (metabotropic glutamate receptor modulator) and racetam [296][297][266]
  • FCE-25876 – serotonin reuptake inhibitor [298]
  • Flerobuterol (CRL-40827) – β-adrenergic receptor agonist [299]
  • Flesinoxan (DU-29373) – serotonin 5-HT1A receptor agonist [300]
  • Flibanserin (Addyi; BIMT-17; Girosa) – serotonin 5-HT1A receptor agonist, serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor antagonist, and dopamine D4 receptor antagonist [301]
  • (R)-Fluoxetine – serotonin reuptake inhibitor [302]
  • Fluparoxan (GR-50360; GR-50360A) – α2-adrenergic receptor antagonist [303]
  • Gaboxadol (LU-02030; LU-2-030; MK-0928; OV-101; THIP) – GABAA receptor agonist [304]
  • Girisopam (EGIS-5810; GYKI-51189) – GABAA receptor positive allosteric modulator and benzodiazepine [305]
  • GYKI-52895 – dopamine reuptake inhibitor [306]
  • Haloperidol (CLR-3001) – typical antipsychotic (non-selective monoamine receptor modulator; low-dose withdrawal therapy) [307][308]
  • HT-2157 (SNAP-37889) – galanin GAL3 receptor antagonist [309]
  • ICI-170809 (ZM-170809) – serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor antagonist [310]
  • Idazoxan – α2-adrenergic receptor antagonist [311]
  • Ipsapirone (BAY-Q-7821; TVX-Q-7821) – serotonin 5-HT1A receptor partial agonist [312]
  • IRFI-165 – adenosine A1 receptor antagonist [313]
  • Istradefylline (KW-6002; Nourianz; Nouriast) – adenosine A2 receptor antagonist [314]
  • JNJ-18038683 – serotonin 5-HT7 receptor antagonist [315]
  • JNJ-19567470 (CRA-5626; R-317573) – corticotropin releasing factor receptor 1 (CRF1) antagonist [316]
  • JNJ-26489112 – unknown mechanism of action (topiramate successor) [317]
  • JNJ-39393406 – α7 nicotinic acetylcholine receptor positive allosteric modulator [318]
  • Lanicemine (AZD-6765) – low-trapping ionotropic glutamate NMDA receptor antagonist [319]
  • LB-100 (LB-1) – protein phosphatase 2A (PP2A) inhibitor [320]
  • Levoprotiline (CGP-12103; CGP-12103A; CGS-12103; R(–)-oxaprotiline; R(–)-hydroxymaprotiline) – histamine H1 receptor antagonist, other actions, and tetracyclic antidepressant [321][322]
  • Lithium – unknown mechanism of action and mood stabilizer [323]
  • Litoxetine (IXA-001; SL-810385) – serotonin reuptake inhibitor and weak serotonin 5-HT3 receptor antagonist [324]
  • Losmapimod (FTX-1821; GS-856553; GSK-856553; GW-856553; GW-856553X) – p38-α/β mitogen-activated protein kinase (MAPK) inhibitor and double homeobox 4 (DUX4) inhibitor [325]
  • LU-AA34893 (LU-AA-34893) – serotonin receptor modulator [326]
  • LU-AA39959 (LU-AA-39959) – ion channel modulator [327]
  • Lubazodone (SM-50C; YM-35992; YM-992) – serotonin reuptake inhibitor and serotonin 5-HT2A receptor antagonist [328]
  • Masitinib (AB-07105; AB-1010; Alsitek; Masican; Masipro; Masiviera) – tyrosine kinase inhibitor and other actions [329]
  • Mecamylamine (Inversine; Tridmac) – nicotinic acetylcholine receptor negative allosteric modulator [330]
  • MIN-117 (WF-516) – serotonin and dopamine reuptake inhibitor, serotonin 5-HT1A and 5-HT7 receptor antagonist, and α1-adrenergic receptor antagonist [331]
  • MK-1942 – undefined mechanism of action [332][333]
  • ML-105 – undefined mechanism of action [334]
  • Naloxone/tianeptine (TNX-601; TNX-601-CR; TNX-601-ER) – weak and atypical μ- and δ-opioid receptor agonist, other actions, tricyclic antidepressant, and μ-opioid receptor antagonist combination [335][336][337]
  • Naluzotan (PRX-00023) – serotonin 5-HT1A receptor partial agonist and sigma σ1 receptor antagonist [338]
  • NB-415 – vasopressin V1b receptor antagonist [339]
  • Neboglamine (nebostinel; CR-2249; XY-2401) – ionotropic glutamate NMDA receptor glycine site positive allosteric modulator [340]
  • Nefiracetam (BRN 6848330; CCRIS 6729; DM 9384; DMPPA; DN-9384; DZL-221; HL-0812; HPI-001; Motiva; Translon) – unknown mechanism of action (voltage-gated calcium channel potentiator, α4β2 nicotinic acetylcholine receptor potentiator, ionotropic glutamate NMDA receptor potentiator (possible glycine site partial positive allosteric modulator), ionotropic glutamate AMPA receptor potentiator, and GABAA receptor agonist) and racetam [341][342][343][344][345][266]
  • Nemifitide (INN-00835) – unknown mechanism of action [346]
  • NS-2359 (GSK-372475) – serotonin, norepinephrine, and dopamine reuptake inhibitor [347]
  • NS-2389 (GW-650250; GW-650250A) – serotonin, norepinephrine, and dopamine reuptake inhibitor [348]
  • ORM-10921 – α2C-adrenergic receptor antagonist [349]
  • Orvepitant (GW-823296; GW-823296X; GW823296) – neurokinin NK1 receptor antagonist [350][351]
  • Osanetant (ACER-801; SR-142801; SR-142806) – neurokinin NK3 receptor antagonist [352]
  • Pexacerfont (BMS-562086) – corticotropin releasing factor receptor 1 (CRF1) antagonist [353]
  • PF-04455242 – κ-opioid receptor antagonist [354]
  • PT-150 (ORG-34517; SCH-900636) – glucocorticoid receptor antagonist and androgen receptor antagonist [355]
  • Radafaxine (GW-353162; (2S,3S)-hydroxybupropion) – norepinephrine and dopamine reuptake inhibitor [356]
  • Ramelteon (Rozerem; TAK-375) – melatonin MT1 and MT2 receptor agonist [357]
  • Rapastinel (BV-102; GLYX-13; TPPT-amide) – ionotropic glutamate NMDA receptor glycine site partial agonist [358]
  • RG-7166 – serotonin, norepinephrine, and dopamine reuptake inhibitor [359]
  • Ritanserin (R-55667) – serotonin 5-HT2A and 5-HT2C receptor antagonist [360]
  • Robalzotan (AZD-7371; NAD-299) – serotonin 5-HT1A receptor antagonist
  • Rolipram (ME-3167; ZK-62711) – phosphodiesterase 4 (PDE4) inhibitor [361]
  • Sabcomeline (BCI-224; CEB-242; Memric; SB-202026) – muscarinic acetylcholine M1 receptor agonist [362]
  • Saredutant (SR-48968) – neurokinin NK2 receptor antagonist[363][364]
  • SB-236057 – serotonin 5-HT1B receptor inverse agonist [365]
  • SB-245570 – serotonin 5-HT1B receptor antagonist [366]
  • Sibutramine (Aoquqing; BTS-54524; Ectiva; KES-524; Meridia; Reductase; Reductil; Reduxade; Sibutral) – serotonin, norepinephrine, and dopamine reuptake inhibitor [367]
  • Siramesine (LU-28179) – sigma σ2 receptor agonist [368]
  • Sirukumab (CNTO-136; Plivensia) – interleukin 6 (IL-6) inhibitor [369]
  • SKL-10406 (SKL-DEP) – serotonin, norepinephrine, and dopamine reuptake inhibitor [370]
  • SKL-PSY (FZ-016) – serotonin 5-HT1A receptor agonist [371]
  • Sodium phenylbutyrate (slow-release; LU-901; Lunaphen) – histone deacetylase (HDAC) inhibitor [372]
  • SSR-149415 (SR-149415) – vasopressin V1b receptor antagonist [373]
  • SSR-241586 – neurokinin NK2 and NK3 receptor antagonist [374]
  • Tandospirone (metanopirone; Sediel; SM-3997) – serotonin 5-HT1A receptor partial agonist and α2-adrenergic receptor antagonist [375]
  • Tasimelteon (BMS-214778; Hetlioz; VEC-162) – melatonin MT1 and MT2 receptor agonist [376]
  • Tedatioxetine (LU-AA24530) – serotonin, norepinephrine, and dopamine reuptake inhibitor, serotonin 5-HT2A, 5-HT2C, and 5-HT3 receptor antagonist, and α1A-adrenergic receptor antagonist [377]
  • Tianeptine (JNJ-39823277; TPI-1062) – weak and atypical μ- and δ-opioid receptor agonist, other actions, and tricyclic antidepressant [378][336][337]
  • TS-111 – undefined mechanism of action [379]
  • Tulrampator (CX-1632; S-47445) – ionotropic glutamate AMPA receptor positive allosteric modulator [380]
  • Vanoxerine (boxeprazine; GBR-12909) – atypical dopamine reuptake inhibitor [381]
  • Verucerfont (GSK-561679; NBI-77860) – corticotropin releasing factor receptor 1 (CRF1) antagonist [382]
  • Vestipitant (GW-597599; GW-597599B) – neurokinin NK1 receptor antagonist [383][253]
  • Viloxazine (Qelbree) – norepinephrine reuptake inhibitor [384]
  • VN-2222 – serotonin reuptake inhibitor and serotonin 5-HT1A receptor partial agonist [385]
  • VUFB-17649 – serotonin reuptake inhibitor [386]
  • VUFB-18285 – serotonin reuptake inhibitor [387]
  • ZD-4974 – neurokinin NK1 receptor antagonist [388]
  • Zelatriazin (TAK-041; NBI-1065846; NBI-846) – G protein-coupled receptor 139 (GPR139) agonist [389]
  • Ziprasidone (Geodon) – atypical antipsychotic (non-selective monoamine receptor modulator) [390]


Preregistration submission withdrawal

[edit]
  • Aripiprazole/sertraline (ASC-01) – atypical antipsychotic (non-selective monoamine receptor modulator) and serotonin reuptake inhibitor combination [391]

Formal development never or not yet started

[edit]
  • Mevidalen (LY-3154207; D1 PAM) – dopamine D1 receptor positive allosteric modulator – under development for Lewy body disease [392][393]
  • Nitrous oxide (N2O; "laughing gas") – ionotropic glutamate NMDA receptor antagonist – being studied for depression but doesn't seem to be being formally developed towards approval[394][395][396][364]

Clinically used drugs

[edit]
Main article: List of antidepressants

Approved drugs

[edit]
  • Agomelatine (Valdoxan) – serotonin 5-HT2C receptor antagonist and melatonin MT1 and MT2 receptor agonist [397]
  • Amineptine (Survector, Maneon) – norepinephrine and dopamine reuptake inhibitor – withdrawn[398]
  • Amisulpride (Solian) – atypical antipsychotic (dopamine D2 and D3 receptor antagonist and serotonin 5-HT2B and 5-HT7 receptor antagonist) [399]
  • Amitriptyline (Elavil) – tricyclic antidepressant (non-selective monoamine reuptake inhibitor and/or receptor modulator)[364]
  • Amoxapine (Asendin) – tetracyclic antidepressant (non-selective monoamine reuptake inhibitor and/or receptor modulator)[364][398]
  • Aripiprazole (Abilify) – atypical antipsychotic (non-selective monoamine receptor modulator) [400]
  • Brexanolone (allopregnanolone; SAGE-547; SGE-102; Zulresso) – GABAA receptor positive allosteric modulator and neurosteroid – approved for postpartum depression [401]
  • Brexpiprazole (Rexulti) – atypical antipsychotic (non-selective monoamine receptor modulator) [402]
  • Bupropion (Wellbutrin) – norepinephrine and dopamine reuptake inhibitor and nicotinic acetylcholine receptor negative allosteric modulator [403]
  • Bupropion/dextromethorphan (Auvelity) – sigma σ1 receptor agonist, serotonin reuptake inhibitor, norepinephrine and dopamine reuptake inhibitor, nicotinic acetylcholine receptor negative allosteric modulator, ionotropic glutamate NMDA receptor antagonist, other actions, and CYP2D6 inhibitor combination [404]
  • Butriptyline (Evadyne) – tricyclic antidepressant (non-selective monoamine reuptake inhibitor and/or receptor modulator) – discontinued[398]
  • Cariprazine (Vraylar) – atypical antipsychotic (non-selective monoamine receptor modulator) [405]
  • Citalopram (Celexa) – serotonin reuptake inhibitor [406]
  • Desipramine (Norpramin) – tricyclic antidepressant (non-selective monoamine reuptake inhibitor and/or receptor modulator)[364]
  • Desvenlafaxine (Pristiq) – serotonin and norepinephrine reuptake inhibitor [407] [408]
  • Desvenlafaxine (extended-release; Khedezla) – serotonin and norepinephrine reuptake inhibitor – withdrawn [409]
  • Desvenlafaxine (extended-release; WIP-DF17) – serotonin and norepinephrine reuptake inhibitor – registered in South Korea [410][411][412]
  • Dosulepin (dothiepin; Prothiaden) – tricyclic antidepressant (non-selective monoamine reuptake inhibitor and/or receptor modulator)[398]
  • Doxepin (Sinequan) – tricyclic antidepressant (non-selective monoamine reuptake inhibitor and/or receptor modulator)[364]
  • Duloxetine (Cymbalta; Drizalma Sprinkle) – serotonin and norepinephrine reuptake inhibitor [413] [414]
  • Escitalopram (Lexapro) – serotonin reuptake inhibitor [415]
  • Esketamine (Spravato) – ionotropic glutamate NMDA receptor antagonist [416]
  • Fluoxetine (Prozac; Sarafem) – serotonin reuptake inhibitor [417] [418]
  • Fluvoxamine (Luvox) – serotonin reuptake inhibitor[364]
  • Gepirone (Exxua) – serotonin 5-HT1A receptor partial agonist and α2-adrenergic receptor antagonist [419]
  • Hypericum extract (LI-160; St John's wort) – undefined mechanism of action [420]
  • Imipramine (Tofranil) – tricyclic antidepressant (non-selective monoamine reuptake inhibitor and/or receptor modulator)[364]
  • Iproniazid (Marsilid) – monoamine oxidase MAO-A and MAO-B irreversible inhibitor – withdrawn[421]
  • Isocarboxazid (Marplan) – monoamine oxidase MAO-A and MAO-B irreversible inhibitor[364][421]
  • Levomilnacipran (Fetzima) – serotonin and norepinephrine reuptake inhibitor [422]
  • Levosulpiride (L-sulpiride; Levobren; Levopraid; Levosulpride; RV-12309; Sulpepta) – dopamine D2 and D3 receptor antagonist and serotonin 5-HT4 receptor agonist [423]
  • Lofepramine (Lomont) – tricyclic antidepressant (non-selective monoamine reuptake inhibitor and/or receptor modulator)[398]
  • Lumateperone (Caplyta) – atypical antipsychotic (non-selective monoamine receptor modulator) [424]
  • Lurasidone (Latuda) – atypical antipsychotic (non-selective monoamine receptor modulator) [425]
  • Maprotiline (Ludiomil) – tetracyclic antidepressant (non-selective monoamine reuptake inhibitor and/or receptor modulator)[398]
  • Mianserin (Tolvon) – tetracyclic antidepressant (non-selective monoamine reuptake inhibitor and/or receptor modulator)[398]
  • Milnacipran (Dalcipran; Ixel; Savella) – serotonin and norepinephrine reuptake inhibitor [426]
  • Mirtazapine (Remeron) – α2-adrenergic receptor antagonist, serotonin 5-HT2A, 5-HT2C, and 5-HT3 receptor antagonist, histamine H1 receptor inverse agonist, and tetracyclic antidepressant [427]
  • Moclobemide (Aurorix; Manerix) – monoamine oxidase MAO-A reversible inhibitor [428][421]
  • Nefazodone (BMY-13754; Dutonin; MJ-13754; MS-13754; Nefadar; Serzone) – serotonin 5-HT1A receptor ligand, serotonin 5-HT2A and 5-HT2C receptor antagonist, α1- and α2-adrenergic receptor antagonist, weak serotonin, norepinephrine, and dopamine reuptake inhibitor, and other actions – mostly withdrawn [429]
  • Nomifensine (Merital; Alival) – norepinephrine and dopamine reuptake inhibitor – withdrawn[398]
  • Nortriptyline (Aventyl) – tricyclic antidepressant (non-selective monoamine reuptake inhibitor and/or receptor modulator)[364]
  • Olanzapine (Zyprexa) – atypical antipsychotic (non-selective monoamine receptor modulator) [430]
  • Olanzapine/fluoxetine (OFC; Symbyax; ZypZac) – atypical antipsychotic (non-selective monoamine receptor modulator) and serotonin reuptake inhibitor combination [431]
  • Opipramol (Ensidon; G-33040; Insidon; Nisidana) – sigma σ1 and σ2 receptor agonist, serotonin 5-HT2A receptor antagonist, dopamine D2 receptor antagonist, α1-adrenergic receptor antagonist, histamine H1 receptor antagonist, other actions, and tricyclic antidepressant [432]
  • Paroxetine (Paxil; Seroxat) – serotonin reuptake inhibitor [433] [434]
  • Phenelzine (Nardil) – monoamine oxidase MAO-A and MAO-B irreversible inhibitor[364][421]
  • Protriptyline (Vivactil) – tricyclic antidepressant (non-selective monoamine reuptake inhibitor and/or receptor modulator)[398]
  • Quetiapine (Seroquel) – atypical antipsychotic (non-selective monoamine receptor modulator) [435]
  • Reboxetine (Edronax) – norepinephrine reuptake inhibitor [436]
  • Selegiline (Emsam) – monoamine oxidase MAO-B irreversible inhibitor, catecholaminergic activity enhancer, and weak norepineprhine releasing agent (via metabolites) [437]
  • Sertraline (Zoloft; Lustral) – serotonin reuptake inhibitor [438]
  • Setiptiline (Tecipul; Tesolon) – serotonin receptor antagonist, α2-adrenergic receptor antagonist, norepinephrine reuptake inhibitor, and tetracyclic antidepressant [439]
  • Tianeptine (Coaxil; Stablon; Tatinol) – weak and atypical μ- and δ-opioid receptor agonist, other actions, and tricyclic antidepressant [440][336][337]
  • Toludesvenlafaxine (ansofaxine; 4-methylbenzoate desvenlafaxine; desvenlafaxine prodrug; LPM-570065; LY-03005; Ruoxinlin) – serotonin, norepinephrine, and dopamine reuptake inhibitor [441]
  • Tranylcypromine (Parnate) – monoamine oxidase MAO-A and MAO-B irreversible inhibitor[364][421]
  • Trazodone (Oleptro; Trittico) – serotonin 5-HT1A receptor partial agonist, serotonin 5-HT2A and 5-HT2C receptor antagonist, α1- and α2-adrenergic receptor antagonist, weak serotonin reuptake inhibitor, and other actions [442]
  • Trimipramine (Surmontil) – tricyclic antidepressant (non-selective monoamine reuptake inhibitor and/or receptor modulator)[364]
  • Venlafaxine (Effexor) – serotonin and norepinephrine reuptake inhibitor [443]
  • Vilazodone (Viibryd) – serotonin reuptake inhibitor and serotonin 5-HT1A receptor agonist [444]
  • Viloxazine (Vivalan) – norepinephrine reuptake inhibitor[398]
  • Vortioxetine (Trintellix) – serotonin reuptake inhibitor, serotonin 5-HT1A and 5-HT1B receptor agonist, and serotonin 5-HT1D, 5-HT3, and 5-HT7 receptor antagonist [445]
  • Zimelidine (Zelmid) – serotonin reuptake inhibitor – withdrawn[398]
  • Zuranolone (BIIB-125; S-812217; SAGE-217; SGE-797; Zurzuvae) – GABAA receptor positive allosteric modulator and neurosteroid – approved for postpartum depression [446]

See also

[edit]

References

[edit]
  1. ^ "Buprenorphine/samidorphan - Alkermes - AdisInsight". adisinsight.springer.com.
  2. ^ Taylor NP (4 February 2019). "FDA rejects Alkermes' depression drug ALKS 5461". Fierce Biotech. Retrieved 8 August 2024.
  3. ^ "Aticaprant - Johnson & Johnson Innovative Medicine - AdisInsight". adisinsight.springer.com.
  4. ^ "CYB 003 - AdisInsight". adisinsight.springer.com.
  5. ^ "Delving into the Latest Updates on CYB-003 with Synapse". synapse.patsnap.com.
  6. ^ Palfreyman M, Krakowsky J, Morgan M, Canal C, Pathare P, Avery K, et al. (December 2022). "ACNP 61st Annual Meeting: Poster Abstracts P271-P540: P361. In Vitro and In Vivo Profile of CYB003: A Novel, Deuterated Psilocybin Analog for the Potential Treatment of Major Depressive Disorder" (PDF). Neuropsychopharmacology. 47 (Suppl 1): 220–370 (271). doi:10.1038/s41386-022-01485-0. PMC 9714399. PMID 36456694.
  7. ^ Inamdar A, Morgan M, Krakowsky J, Reichelt A, Canal C, Mueller T, et al. (December 2022). "ACNP 61st Annual Meeting: Poster Abstracts P271-P540: P362. Pharmacokinetic Profile of CYB003: A Novel, Deuterated Psilocybin Analog for the Potential Treatment of Major Depressive Disorder" (PDF). Neuropsychopharmacology. 47 (Suppl 1): 220–370 (271–272). doi:10.1038/s41386-022-01485-0. PMC 9714399. PMID 36456694.
  8. ^ "Cycloserine/lurasidone - NRx Pharmaceuticals - AdisInsight". adisinsight.springer.com.
  9. ^ "Esmethadone - Relmada Therapeutics - AdisInsight". adisinsight.springer.com.
  10. ^ "Ketamine - NRx Pharmaceuticals - AdisInsight". adisinsight.springer.com.
  11. ^ "Navacaprant - Neumora Therapeutics - AdisInsight". adisinsight.springer.com.
  12. ^ "Pimavanserin - ACADIA Pharmaceuticals - AdisInsight". adisinsight.springer.com.
  13. ^ "Psilocybin - COMPASS Pathways - AdisInsight". adisinsight.springer.com.
  14. ^ Najib J (August 2024). "The role of psilocybin in depressive disorders". Curr Med Res Opin. 40 (10): 1793–1808. doi:10.1080/03007995.2024.2396536. PMID 39177339.
  15. ^ "Seltorexant - Janssen Research & Development/Minerva Neurosciences - AdisInsight". adisinsight.springer.com.
  16. ^ "SEP 4199 - AdisInsight". adisinsight.springer.com.
  17. ^ "SNG 12 - AdisInsight". adisinsight.springer.com.
  18. ^ "Solriamfetol - Jazz Pharmaceuticals/SK Biopharmaceuticals - AdisInsight". adisinsight.springer.com.
  19. ^ "YKP 10A - AdisInsight". adisinsight.springer.com.
  20. ^ Abad VC, Guilleminault C (December 2018). "Solriamfetol for the treatment of daytime sleepiness in obstructive sleep apnea". Expert Rev Respir Med. 12 (12): 1007–1019. doi:10.1080/17476348.2018.1541742. PMID 30365900. Solriamfetol hydrochloride, previously known as JZP-110, SKLN05, ARL-N05, YKP-10A, R-228060, ADX-N05, was initially developed by the SK Group as YKP-10A, a drug to treat depression. SK Group licensed rights outside of 11 countries in Asia to Aerial BioPharma in 2011. [...]
  21. ^ "Ulotaront - Otsuka Pharmaceutical/Sumitomo Pharma - AdisInsight". adisinsight.springer.com.
  22. ^ "PRAX 114 - AdisInsight". adisinsight.springer.com.
  23. ^ "AV 101 - AdisInsight". adisinsight.springer.com.
  24. ^ "Ademetionine - AdisInsight". adisinsight.springer.com.
  25. ^ "ALTO 100 - AdisInsight". adisinsight.springer.com.
  26. ^ "NSI 189 - AdisInsight". adisinsight.springer.com.
  27. ^ "ALTO 203 - AdisInsight". adisinsight.springer.com.
  28. ^ "Apimostinel - AbbVie - AdisInsight". adisinsight.springer.com.
  29. ^ "Arketamine - ATAI Life Sciences - AdisInsight". adisinsight.springer.com.
  30. ^ "Azetukalner - Xenon Pharmaceuticals - AdisInsight". adisinsight.springer.com.
  31. ^ "BHV 7000 - AdisInsight". adisinsight.springer.com.
  32. ^ "BI 1358894 - AdisInsight". adisinsight.springer.com.
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  34. ^ "ANC 501 - AdisInsight". adisinsight.springer.com.
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  227. ^ "SD 254 - AdisInsight". adisinsight.springer.com.
  228. ^ "SEP 378614 - AdisInsight". adisinsight.springer.com.
  229. ^ "SNA 1 - AdisInsight". adisinsight.springer.com.
  230. ^ "SPL 801 B - AdisInsight". adisinsight.springer.com.
  231. ^ "Tropomyosin-related kinase B receptor antagonist - Celon Pharma - AdisInsight". adisinsight.springer.com.
  232. ^ "YDP 2225 - AdisInsight". adisinsight.springer.com.
  233. ^ "ABT 436 - AdisInsight". adisinsight.springer.com.
  234. ^ "Adatanserin - AdisInsight". adisinsight.springer.com.
  235. ^ "ADX 71149 - AdisInsight". adisinsight.springer.com.
  236. ^ "Amesergide - AdisInsight". adisinsight.springer.com.
  237. ^ "Amibegron - sanofi-aventis - AdisInsight". adisinsight.springer.com.
  238. ^ Rupniak NM, Kramer MS (December 2017). "NK1 receptor antagonists for depression: Why a validated concept was abandoned". J Affect Disord. 223: 121–125. doi:10.1016/j.jad.2017.07.042. PMID 28753469.
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  240. ^ "Aprepitant Completed Phase 3 Trials for Major Depressive Disorder (MDD) Treatment". DrugBank Online. Retrieved 9 August 2024.
  241. ^ "ARA 014418 - AdisInsight". adisinsight.springer.com.
  242. ^ "Armodafinil - Teva Pharmaceutical Industries - AdisInsight". adisinsight.springer.com.
  243. ^ "Atipamezole - AdisInsight". adisinsight.springer.com.
  244. ^ "Atomoxetine - Eli Lilly and Company - AdisInsight". adisinsight.springer.com.
  245. ^ "AZD 2066 - AdisInsight". adisinsight.springer.com.
  246. ^ "AZD 2327 - AdisInsight". adisinsight.springer.com.
  247. ^ "AZD 7268 - AdisInsight". adisinsight.springer.com.
  248. ^ "AZD 8129 - AdisInsight". adisinsight.springer.com.
  249. ^ "Basimglurant - Noema Pharma - AdisInsight". adisinsight.springer.com.
  250. ^ "Befloxatone - AdisInsight". adisinsight.springer.com.
  251. ^ "BMS 181101 - AdisInsight". adisinsight.springer.com.
  252. ^ "Buspirone transdermal - Bristol-Myers Squibb/Elan - AdisInsight". adisinsight.springer.com.
  253. ^ a b Trist DG, Ratti E, Bye A (December 2013). "Why receptor reserve matters for neurokinin1 (NK1) receptor antagonists". J Recept Signal Transduct Res. 33 (6): 333–7. doi:10.3109/10799893.2013.843194. PMID 24106886.
  254. ^ "Centpropazine - AdisInsight". adisinsight.springer.com.
  255. ^ Ashrafuzzaman M, Ji SH, Ahn H, Chung HW, Choi D, Park JJ, et al. (29 March 2023). "Identification of 1-phenoxy-3-(piperazin-1-yl)propan-2-ol derivatives as novel triple reuptake inhibitors". Bulletin of the Korean Chemical Society. 44 (7). Wiley: 596–599. doi:10.1002/bkcs.12693. ISSN 1229-5949. Centpropazine, possessing the 1-aryloxy-3-(piperazin-1-yl)propan-2-ol scaffold is an antidepressant, only marketed in India, and has never been clinically approved likely due to its low bioavailability (Figure 2).10 To the best of our knowledge, the exact modes of action of centpropazine are unclear. The fact that centpropazine possesses antidepressant effects is remarkable. Although its efficacy in treating depressive symptoms has been previously investigated,11-13 its pharmacological studies of the specific monoamines affected have not been reported.
  256. ^ "Cibinetide - Araim Pharmaceuticals - AdisInsight". adisinsight.springer.com.
  257. ^ "Citalopram controlled release - Lundbeck A/S/Bausch Health Companies - AdisInsight". adisinsight.springer.com.
  258. ^ "Clavulanic acid - Opus Genetics - AdisInsight". adisinsight.springer.com.
  259. ^ Balcazar-Ochoa LG, Ventura-Martínez R, Ángeles-López GE, Gómez-Acevedo C, Carrasco OF, Sampieri-Cabrera R, et al. (January 2024). "Clavulanic Acid and its Potential Therapeutic Effects on the Central Nervous System". Arch Med Res. 55 (1): 102916. doi:10.1016/j.arcmed.2023.102916. PMID 38039802.
  260. ^ Ochoa-Aguilar A, Ventura-Martinez R, Sotomayor-Sobrino MA, Gómez C, Morales-Espinoza MR (2016). "Review of Antibiotic and Non-Antibiotic Properties of Beta-lactam Molecules". Anti-Inflamm Anti-Allergy Agents Med Chem. 15 (1): 3–14. doi:10.2174/1871523015666160517114027. PMID 27185396.
  261. ^ Connolly KR, Thase ME (March 2012). "Emerging drugs for major depressive disorder". Expert Opin Emerg Drugs. 17 (1): 105–126. doi:10.1517/14728214.2012.660146. PMID 22339643.
  262. ^ Riesenberg R, Rosenthal J, Moldauer L, Peterson C (June 2012). "Results of a proof-of-concept, dose-finding, double-blind, placebo-controlled study of RX-10100 (Serdaxin®) in subjects with major depressive disorder". Psychopharmacology (Berl). 221 (4): 601–610. doi:10.1007/s00213-011-2604-x. PMID 22203317.
  263. ^ Kost GC, Selvaraj S, Lee YB, Kim DJ, Ahn CH, Singh BB (October 2011). "Clavulanic acid increases dopamine release in neuronal cells through a mechanism involving enhanced vesicle trafficking". Neurosci Lett. 504 (2): 170–175. doi:10.1016/j.neulet.2011.09.032. PMC 3195833. PMID 21964384.
  264. ^ "Clovoxamine - AdisInsight". adisinsight.springer.com.
  265. ^ "Coluracetam - AdisInsight". adisinsight.springer.com.
  266. ^ a b c Malykh AG, Sadaie MR (February 2010). "Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders". Drugs. 70 (3): 287–312. doi:10.2165/11319230-000000000-00000. PMID 20166767.
  267. ^ Schifano F, Catalani V, Sharif S, Napoletano F, Corkery JM, Arillotta D, et al. (April 2022). "Benefits and Harms of 'Smart Drugs' (Nootropics) in Healthy Individuals". Drugs. 82 (6): 633–647. doi:10.1007/s40265-022-01701-7. PMID 35366192.
  268. ^ Zarate CA, Machado-Vieira R (March 2017). "Ketamine: translating mechanistic discoveries into the next generation of glutamate modulators for mood disorders". Mol Psychiatry. 22 (3): 324–327. doi:10.1038/mp.2016.249. PMC 5641407. PMID 28070122. Because AMPA appeared critical to ketamine's antidepressant effects, researchers reasoned that AMPA positive modulators—also known as AMPAkines—could positively influence mood. Previous studies evaluating AMPAkines in mood disorders achieved mixed results, potentially due to low bioavailability and toxicity profile.20 To overcome the issue of low bioavailability, other AMPAkines were recently developed and tested in initial Phase 1 and 2 studies, particularly coluracetam (BCI-540)21 and ORG-26576.22 Both agents showed preliminary therapeutic effects in major depressive disorder when tested in small samples.23,24
  269. ^ "CP 316311 - AdisInsight". adisinsight.springer.com.
  270. ^ "Crinecerfont - Neurocrine Biosciences - AdisInsight". adisinsight.springer.com.
  271. ^ "CRL 41789 - AdisInsight". adisinsight.springer.com.
  272. ^ "Cutamesine - AdisInsight". adisinsight.springer.com.
  273. ^ Borbély É, Simon M, Fuchs E, Wiborg O, Czéh B, Helyes Z (March 2022). "Novel drug developmental strategies for treatment-resistant depression". Br J Pharmacol. 179 (6): 1146–1186. doi:10.1111/bph.15753. PMC 9303797. PMID 34822719.
  274. ^ "Dapoxetine - AdisInsight". adisinsight.springer.com.
  275. ^ "Dasotraline - Sumitomo Pharma - AdisInsight". adisinsight.springer.com.
  276. ^ "DDP 225 - AdisInsight". adisinsight.springer.com.
  277. ^ "Decoglurant - AdisInsight". adisinsight.springer.com.
  278. ^ "Delequamine - AdisInsight". adisinsight.springer.com.
  279. ^ "Delucemine - AdisInsight". adisinsight.springer.com.
  280. ^ "Dexmecamylamine - Atacama Therapeutics - AdisInsight". adisinsight.springer.com.
  281. ^ "Dexnafenodone - AdisInsight". adisinsight.springer.com.
  282. ^ "DMP 695 - AdisInsight". adisinsight.springer.com.
  283. ^ "DOV 216303 - AdisInsight". adisinsight.springer.com.
  284. ^ "DPC 368 - AdisInsight". adisinsight.springer.com.
  285. ^ "DSP 1200 - AdisInsight". adisinsight.springer.com.
  286. ^ "Edivoxetine - AdisInsight". adisinsight.springer.com.
  287. ^ Dale E, Pehrson AL, Jeyarajah T, Li Y, Leiser SC, Smagin G, et al. (April 2016). "Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function". CNS Spectr. 21 (2): 143–161. doi:10.1017/S1092852915000425. PMC 4825106. PMID 26346726. The 5-HT1B/1D receptor antagonist elzasonan (CP-448187) was recently under development for the treatment of MDD and was tested in several phase-2 clinical trials, but its development program was also discontinued.140
  288. ^ "Emapunil - Dainippon Sumitomo/Novartis - AdisInsight". adisinsight.springer.com.
  289. ^ "Emicerfont - AdisInsight". adisinsight.springer.com.
  290. ^ "Eplivanserin - AdisInsight". adisinsight.springer.com.
  291. ^ "Eptapirone - AdisInsight". adisinsight.springer.com.
  292. ^ "Esreboxetine - Axsome Therapeutics - AdisInsight". adisinsight.springer.com.
  293. ^ "Esuprone - AdisInsight". adisinsight.springer.com.
  294. ^ "Ethyl eicosapentaenoic acid - Amarin - AdisInsight". adisinsight.springer.com.
  295. ^ "Farampator - AdisInsight". adisinsight.springer.com.
  296. ^ "Fasoracetam - Avalo Therapeutics - AdisInsight". adisinsight.springer.com.
  297. ^ Connolly JJ, Glessner JT, Elia J, Hakonarson H (September 2015). "ADHD & Pharmacotherapy: Past, Present and Future: A Review of the Changing Landscape of Drug Therapy for Attention Deficit Hyperactivity Disorder". Ther Innov Regul Sci. 49 (5): 632–642. doi:10.1177/2168479015599811. PMC 4564067. PMID 26366330.
  298. ^ "FCE 25876 - AdisInsight". adisinsight.springer.com.
  299. ^ "Flerobuterol - AdisInsight". adisinsight.springer.com.
  300. ^ "Flesinoxan - AdisInsight". adisinsight.springer.com.
  301. ^ "Flibanserin - Sprout Pharmaceuticals - AdisInsight". adisinsight.springer.com.
  302. ^ "R-fluoxetine - AdisInsight". adisinsight.springer.com.
  303. ^ "Fluparoxan - AdisInsight". adisinsight.springer.com.
  304. ^ "Gaboxadol - Lundbeck A/S - AdisInsight". adisinsight.springer.com.
  305. ^ "Girisopam - AdisInsight". adisinsight.springer.com.
  306. ^ "GYKI 52895 - AdisInsight". adisinsight.springer.com.
  307. ^ "CLR 3001 - AdisInsight". adisinsight.springer.com.
  308. ^ Kennedy SH, Giacobbe P, Placenza F, Hudson CJ, Seeman P, Seeman MV (September 2014). "Depression treatment by withdrawal of short-term low-dose antipsychotic, a proof-of-concept randomized double-blind study". J Affect Disord. 166: 139–143. doi:10.1016/j.jad.2014.04.014. PMID 25012422.
  309. ^ "HT 2157 - AdisInsight". adisinsight.springer.com.
  310. ^ "ICI 170809 - AdisInsight". adisinsight.springer.com.
  311. ^ "Idazoxan - AdisInsight". adisinsight.springer.com.
  312. ^ "Ipsapirone - AdisInsight". adisinsight.springer.com.
  313. ^ "IRFI 165 - AdisInsight". adisinsight.springer.com.
  314. ^ "Istradefylline - Kyowa Kirin - AdisInsight". adisinsight.springer.com.
  315. ^ "JNJ 18038683 - AdisInsight". adisinsight.springer.com.
  316. ^ "JNJ 19567470 - AdisInsight". adisinsight.springer.com.
  317. ^ "JNJ 26489112 - AdisInsight". adisinsight.springer.com.
  318. ^ "JNJ 39393406 - AdisInsight". adisinsight.springer.com.
  319. ^ "Lanicemine - AstraZeneca - AdisInsight". adisinsight.springer.com.
  320. ^ "LB 100 - AdisInsight". adisinsight.springer.com.
  321. ^ "Levoprotiline - AdisInsight". adisinsight.springer.com.
  322. ^ Noguchi S, Inukai T (May 1992). "Repeated treatment with levoprotiline, a novel antidepressant, up-regulates histamine H1 receptors and phosphoinositide hydrolysis response in vivo". Jpn J Pharmacol. 59 (1): 31–35. doi:10.1254/jjp.59.31. PMID 1324374.
  323. ^ "Lithium - Columbia Northwest Pharmaceuticals - AdisInsight". adisinsight.springer.com.
  324. ^ "Litoxetine - IXALTIS - AdisInsight". adisinsight.springer.com.
  325. ^ "Losmapimod - Fulcrum Therapeutics - AdisInsight". adisinsight.springer.com.
  326. ^ "LU AA34893 - AdisInsight". adisinsight.springer.com.
  327. ^ "LUAA 399599 - AdisInsight". adisinsight.springer.com.
  328. ^ "Lubazodone - AdisInsight". adisinsight.springer.com.
  329. ^ "Masitinib - AB Science - AdisInsight". adisinsight.springer.com.
  330. ^ "Mecamylamine - Targacept - AdisInsight". adisinsight.springer.com.
  331. ^ "MIN 117 - AdisInsight". adisinsight.springer.com.
  332. ^ "MK 1942 - AdisInsight". adisinsight.springer.com.
  333. ^ "Delving into the Latest Updates on MK-1942 with Synapse". Synapse. 15 October 2024. Retrieved 31 October 2024.
  334. ^ "ML 105 - AdisInsight". adisinsight.springer.com.
  335. ^ "Naloxone/tianeptine - Tonix Pharmaceuticals - AdisInsight". adisinsight.springer.com.
  336. ^ a b c Edinoff AN, Sall S, Beckman SP, Koepnick AD, Gold LC, Jackson ED, et al. (October 2023). "Tianeptine, an Antidepressant with Opioid Agonist Effects: Pharmacology and Abuse Potential, a Narrative Review". Pain Ther. 12 (5): 1121–1134. doi:10.1007/s40122-023-00539-5. PMC 10444703. PMID 37453966.
  337. ^ a b c Alamo C, García-Garcia P, Lopez-Muñoz F, Zaragozá C (2019). "Tianeptine, an atypical pharmacological approach to depression". Rev Psiquiatr Salud Ment (Engl Ed). 12 (3): 170–186. doi:10.1016/j.rpsmen.2018.09.001. PMID 30612921.
  338. ^ "Naluzotan - Proximagen - AdisInsight". adisinsight.springer.com.
  339. ^ "NB 415 - AdisInsight". adisinsight.springer.com.
  340. ^ "Neboglamine - AdisInsight". adisinsight.springer.com.
  341. ^ "Nefiracetam - AdisInsight". adisinsight.springer.com.
  342. ^ Narahashi T, Moriguchi S, Zhao X, Marszalec W, Yeh JZ (November 2004). "Mechanisms of action of cognitive enhancers on neuroreceptors". Biol Pharm Bull. 27 (11): 1701–1706. doi:10.1248/bpb.27.1701. PMID 15516710.
  343. ^ Yoshii M, Watabe S, Murashima YL, Nukada T, Shiotani T, Nishizaki T (2001). "Neuronal Ca 2+ Channels and Nicotinic ACh Receptors as Functional Targets of the Nootropic Nefiracetam". Psychogeriatrics. 1 (1): 39–49. doi:10.1111/j.1479-8301.2001.tb00071.x. ISSN 1346-3500.
  344. ^ Gualtieri F, Manetti D, Romanelli MN, Ghelardini C (2002). "Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs". Curr Pharm Des. 8 (2): 125–38. doi:10.2174/1381612023396582. PMID 11812254. In general, piracetam-like nootropics show no affinity for the most important central receptors (Ki > 10 μM). A modest affinity for muscarinic receptors is shown by aniracetam (Ki = 4.4 μM [58]) and nebracetam (Ki = 6.3 μM [61]). Nefiracetam is the only one showing affinity in the nanomolar range (Ki = 8.5 nM on the GABAA receptor [58]). [...] Nefiracetam (chart (1)) is awaiting approval. It presents a variety of pharmacological actions as it is reported to activate the cholinergic, GABAergic and other monaminergic systems and to modulate N-type calcium channels [78-81].
  345. ^ Gouliaev AH, Senning A (May 1994). "Piracetam and other structurally related nootropics". Brain Res Brain Res Rev. 19 (2): 180–222. doi:10.1016/0165-0173(94)90011-6. PMID 8061686. As mentioned above, no commonly accepted mechanism for the racetam nootropics has yet been established, They do not seem to act on any well characterised receptor site with the exception of nefiracetam which has high affinity for GABA, receptors (see Table 1). [...] Receptor: GABAA. Receptor ligand: [3H]muscimolA. Compound: nefiracetam. IC50: 8.5 nMB. Refs.: 222. [...] From Table 1 it is, however, evident that the piracetam-like nootropics do not exhibit high affinity for any of the receptor types tested so far (except for nefiracetam, which shows some activity at GABAA receptors)
  346. ^ "Nemifitide - AdisInsight". adisinsight.springer.com.
  347. ^ "NS 2359 - AdisInsight". adisinsight.springer.com.
  348. ^ "NS 2389 - AdisInsight". adisinsight.springer.com.
  349. ^ "ORM 10921 - AdisInsight". adisinsight.springer.com.
  350. ^ "Orvepitant - NeRRe therapeutics - AdisInsight". adisinsight.springer.com.
  351. ^ Ratti E, Bettica P, Alexander R, Archer G, Carpenter D, Evoniuk G, et al. (May 2013). "Full central neurokinin-1 receptor blockade is required for efficacy in depression: evidence from orvepitant clinical studies". J Psychopharmacol. 27 (5): 424–434. doi:10.1177/0269881113480990. PMID 23539641.
  352. ^ "Osanetant - Acer Therapeutics - AdisInsight". adisinsight.springer.com.
  353. ^ "Pexacerfont - AdisInsight". adisinsight.springer.com.
  354. ^ "PF 4455242 - AdisInsight". adisinsight.springer.com.
  355. ^ "PT 150 - AdisInsight". adisinsight.springer.com.
  356. ^ "Radafaxine - AdisInsight". adisinsight.springer.com.
  357. ^ "Ramelteon - Takeda - AdisInsight". adisinsight.springer.com.
  358. ^ "Rapastinel - Gate Neurosciences - AdisInsight". adisinsight.springer.com.
  359. ^ "RG 7166 - AdisInsight". adisinsight.springer.com.
  360. ^ "Ritanserin - AdisInsight". adisinsight.springer.com.
  361. ^ "Rolipram - AdisInsight". adisinsight.springer.com.
  362. ^ "Sabcomeline - AdisInsight". adisinsight.springer.com.
  363. ^ Quartara L, Altamura M, Evangelista S, Maggi CA (December 2009). "Tachykinin receptor antagonists in clinical trials". Expert Opin Investig Drugs. 18 (12): 1843–1864. doi:10.1517/13543780903379530. PMID 19938899.
  364. ^ a b c d e f g h i j k l m Namiot ED, Smirnovová D, Sokolov AV, Chubarev VN, Tarasov VV, Schiöth HB (July 2024). "Depression clinical trials worldwide: a systematic analysis of the ICTRP and comparison with ClinicalTrials.gov". Transl Psychiatry. 14 (1): 315. doi:10.1038/s41398-024-03031-6. PMC 11291508. PMID 39085220.
  365. ^ "SB 236057 - AdisInsight". adisinsight.springer.com.
  366. ^ "SB 245570 - AdisInsight". adisinsight.springer.com.
  367. ^ "Sibutramine - Abbvie - AdisInsight". adisinsight.springer.com.
  368. ^ "Siramesine - AdisInsight". adisinsight.springer.com.
  369. ^ "Sirukumab - Janssen Biotech - AdisInsight". adisinsight.springer.com.
  370. ^ "SKL 10406 - AdisInsight". adisinsight.springer.com.
  371. ^ "SKL PSY - AdisInsight". adisinsight.springer.com.
  372. ^ "Sodium phenylbutyrate slow-release - LUNAMeD AG - AdisInsight". adisinsight.springer.com.
  373. ^ "SSR 149415 - AdisInsight". adisinsight.springer.com.
  374. ^ "SSR 241586 - AdisInsight". adisinsight.springer.com.
  375. ^ "Tandospirone - AdisInsight". adisinsight.springer.com.
  376. ^ "Tasimelteon - Vanda Pharmaceuticals - AdisInsight". adisinsight.springer.com.
  377. ^ "Tedatioxetine - AdisInsight". adisinsight.springer.com.
  378. ^ "Tianeptine oral - Johnson & Johnson - AdisInsight". adisinsight.springer.com.
  379. ^ "TS 111 - AdisInsight". adisinsight.springer.com.
  380. ^ "Tulrampator - RespireRx Pharmaceuticals/Servier - AdisInsight". adisinsight.springer.com.
  381. ^ "Vanoxerine - AdisInsight". adisinsight.springer.com.
  382. ^ "Verucerfont - GlaxoSmithKline - AdisInsight". adisinsight.springer.com.
  383. ^ "Vestipitant - AdisInsight". adisinsight.springer.com.
  384. ^ "Viloxazine hydrochloride - Supernus Pharmaceuticals - AdisInsight". adisinsight.springer.com.
  385. ^ "VN 2222 - AdisInsight". adisinsight.springer.com.
  386. ^ "VUFB 17649 - AdisInsight". adisinsight.springer.com.
  387. ^ "VUFB 18285 - AdisInsight". adisinsight.springer.com.
  388. ^ "ZD 4974 - AdisInsight". adisinsight.springer.com.
  389. ^ "TAK 041 - AdisInsight". adisinsight.springer.com.
  390. ^ "Ziprasidone - Pfizer - AdisInsight". adisinsight.springer.com.
  391. ^ "Aripiprazole/sertraline - Otsuka Pharmaceutical - AdisInsight". adisinsight.springer.com.
  392. ^ "Mevidalen - Eli Lilly and Company - AdisInsight". adisinsight.springer.com.
  393. ^ Svensson KA, Hao J, Bruns RF (2019). "Positive allosteric modulators of the dopamine D1 receptor: A new mechanism for the treatment of neuropsychiatric disorders". Neuropsychotherapeutics. Adv Pharmacol. Vol. 86. pp. 273–305. doi:10.1016/bs.apha.2019.06.001. ISBN 978-0-12-816668-0. PMID 31378255. The close structural analog of DETQ, LY3154207, is currently in phase 2 testing for Lewy Body dementias, including patients with Parkinson's disease.
  394. ^ Sakurai H, Yonezawa K, Tani H, Mimura M, Bauer M, Uchida H (July 2022). "Novel Antidepressants in the Pipeline (Phase II and III): A Systematic Review of the US Clinical Trials Registry". Pharmacopsychiatry. 55 (4): 193–202. doi:10.1055/a-1714-9097. PMC 9259184. PMID 35045580.
  395. ^ Brenna CT, Goldstein BI, Zarate CA, Orser BA (August 2024). "Repurposing General Anesthetic Drugs to Treat Depression: A New Frontier for Anesthesiologists in Neuropsychiatric Care". Anesthesiology. 141 (2): 222–237. doi:10.1097/ALN.0000000000005037. PMID 38856663.
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  397. ^ "Agomelatine - Servier - AdisInsight". adisinsight.springer.com.
  398. ^ a b c d e f g h i j k Sharma H, Santra S, Dutta A (2015). "Triple reuptake inhibitors as potential next-generation antidepressants: a new hope?". Future Med Chem. 7 (17): 2385–406. doi:10.4155/fmc.15.134. PMC 4976848. PMID 26619226.
  399. ^ "Amisulpride - AdisInsight". adisinsight.springer.com.
  400. ^ "Aripiprazole - Bristol-Myers Squibb/Otsuka Pharmaceutical - AdisInsight". adisinsight.springer.com.
  401. ^ "Brexanolone - Sage Therapeutics - AdisInsight". adisinsight.springer.com.
  402. ^ "Brexpiprazole - Lundbeck/Otsuka - AdisInsight". adisinsight.springer.com.
  403. ^ "Bupropion - Biovail Corporation - AdisInsight". adisinsight.springer.com.
  404. ^ "Bupropion/dextromethorphan - Axsome Therapeutics - AdisInsight". adisinsight.springer.com.
  405. ^ "Cariprazine - Gedeon Richter - AdisInsight". adisinsight.springer.com.
  406. ^ "Citalopram orally disintegrating tablets - Bausch Health Companies - AdisInsight". adisinsight.springer.com.
  407. ^ "Desvenlafaxine - Pfizer - AdisInsight". adisinsight.springer.com.
  408. ^ "Desvenlafaxine - extended release - Alembic - AdisInsight". adisinsight.springer.com.
  409. ^ "Desvenlafaxine extended-release - RVL Pharmaceuticals - AdisInsight". adisinsight.springer.com.
  410. ^ "WIP DF17 - AdisInsight". adisinsight.springer.com.
  411. ^ "인하대병원 임상시험센터". 인하대병원 (in Korean). 15 April 2019. Retrieved 8 August 2024.
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  413. ^ "Duloxetine - Eli Lilly and Company - AdisInsight". adisinsight.springer.com.
  414. ^ "Duloxetine delayed-release capsules - Sun Pharma Global FZE - AdisInsight". adisinsight.springer.com.
  415. ^ "Escitalopram - Lundbeck A/S - AdisInsight". adisinsight.springer.com.
  416. ^ "Esketamine - Johnson & Johnson - AdisInsight". adisinsight.springer.com.
  417. ^ "Fluoxetine - Eli Lilly - AdisInsight". adisinsight.springer.com.
  418. ^ "Fluoxetine - Edgemont Pharmaceuticals - AdisInsight". adisinsight.springer.com.
  419. ^ "Gepirone - Fabre-Kramer Pharmaceuticals - AdisInsight". adisinsight.springer.com.
  420. ^ "Hypericum extract - Lichtwer Pharma - AdisInsight". adisinsight.springer.com.
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  422. ^ "Levomilnacipran - AbbVie/Pierre Fabre - AdisInsight". adisinsight.springer.com.
  423. ^ "Levosulpiride - AdisInsight". adisinsight.springer.com.
  424. ^ "Lumateperone - Intra-Cellular Therapies - AdisInsight". adisinsight.springer.com.
  425. ^ "Lurasidone - Sumitomo Pharma - AdisInsight". adisinsight.springer.com.
  426. ^ "Milnacipran - Pierre Fabre - AdisInsight". adisinsight.springer.com.
  427. ^ "Mirtazapine - Merck & Co - AdisInsight". adisinsight.springer.com.
  428. ^ "Moclobemide - AdisInsight". adisinsight.springer.com.
  429. ^ "Nefazodone - AdisInsight". adisinsight.springer.com.
  430. ^ "Olanzapine - Eli Lilly and Company - AdisInsight". adisinsight.springer.com.
  431. ^ "Olanzapine/fluoxetine - Eli Lilly and Company - AdisInsight". adisinsight.springer.com.
  432. ^ "Opipramol - AdisInsight". adisinsight.springer.com.
  433. ^ "Paroxetine - Novo Nordisk - AdisInsight". adisinsight.springer.com.
  434. ^ "Paroxetine hydrochloride - Italfarmaco - AdisInsight". adisinsight.springer.com.
  435. ^ "Quetiapine - AstraZeneca - AdisInsight". adisinsight.springer.com.
  436. ^ "Reboxetine - AdisInsight". adisinsight.springer.com.
  437. ^ "Selegiline transdermal - Somerset Pharmaceuticals - AdisInsight". adisinsight.springer.com.
  438. ^ "Sertraline - Pfizer - AdisInsight". adisinsight.springer.com.
  439. ^ "Setiptiline - AdisInsight". adisinsight.springer.com.
  440. ^ "Tianeptine - Servier - AdisInsight". adisinsight.springer.com.
  441. ^ "Toludesvenlafaxine extended release - Luye Pharma - AdisInsight". adisinsight.springer.com.
  442. ^ "Trazodone - Angelini Group/Labopharm - AdisInsight". adisinsight.springer.com.
  443. ^ "Venlafaxine - Pfizer - AdisInsight". adisinsight.springer.com.
  444. ^ "Vilazodone - AbbVie - AdisInsight". adisinsight.springer.com.
  445. ^ "Vortioxetine - Lundbeck - AdisInsight". adisinsight.springer.com.
  446. ^ "Zuranolone - Biogen/SAGE Therapeutics - AdisInsight". adisinsight.springer.com.

Further reading

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