Estradiol valerate/megestrol acetate

Estradiol valerate /
megestrol acetate
	Estradiol valerate (top) and; megestrol acetate (bottom)
Combination of
Estradiol valerate	Estrogen
Megestrol acetate	Progestogen
Clinical data
Other names	EV/MGA
Routes of; administration	Intramuscular injection (microcapsules)

Estradiol valerate/megestrol acetate (EV/MGA) is a combined injectable contraceptive which was developed in China in the 1980s but was never marketed.^[1]^[2]^[3]^[4]^[5] It is an aqueous suspension of microcapsules (50–80 μm in diameter) containing 5 mg estradiol valerate (EV) and 15 mg megestrol acetate (MGA).^[1]^[2]^[4] It was also studied at doses of EV ranging from 0.5 to 5 mg and at doses of MGA ranging from 15 to 25 mg.^[3]

References

^ ^a ^b Sang GW (April 1994). "Pharmacodynamic effects of once-a-month combined injectable contraceptives". Contraception. 49 (4): 361–85. doi:10.1016/0010-7824(94)90033-7. PMID 8013220.
^ ^a ^b Toppozada MK (April 1994). "Existing once-a-month combined injectable contraceptives". Contraception. 49 (4): 293–301. doi:10.1016/0010-7824(94)90029-9. PMID 8013216.
^ ^a ^b Han ZY, Xiao RQ (August 1984). "Clinical evaluation of intramuscular injection of microencapsulated compound megestrol acetate". Int J Gynaecol Obstet. 22 (4): 319–24. doi:10.1016/0020-7292(84)90091-2. PMID 6152804. S2CID 72806071.
^ ^a ^b Han ZY, Xiao RQ (June 1985). "A follow-up study of the efficacy and safety of injectable microencapsulated megestrol acetate and a discussion on its contraceptive mechanism". Int J Gynaecol Obstet. 23 (3): 207–11. doi:10.1016/0020-7292(85)90106-7. PMID 2865183. S2CID 74276439.
^ Hong Z, Lu B, Wang C (March 1991). "[Determination of megestrol acetate and estradiol valerate in injection of microencapsulated compound megestrol acetate by secondary derivative spectrophotometry]". Hua Xi Yi Ke da Xue Xue Bao (in Chinese). 22 (1): 87–9. PMID 1774044.

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