IL13RA2

IL13RA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LB6
Identifiers
Aliases	IL13RA2, CD213A2, CT19, IL-13R, IL13BP, interleukin 13 receptor subunit alpha 2
External IDs	OMIM: 300130; MGI: 1277954; HomoloGene: 534; GeneCards: IL13RA2; OMA:IL13RA2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	115,019,977 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	146,212,188 bp
RNA expression pattern
	Top expressed in
	sperm; ; Descending thoracic aorta; ; ascending aorta; ; right testis; ; left testis; ; gonad; ; glomerulus; ; metanephric glomerulus; ; testicle; ; anterior pituitary;
	Top expressed in
	cumulus cell; ; pineal gland; ; mesenteric lymph nodes; ; uterus; ; lip; ; gastrula; ; ascending aorta; ; aortic valve; ; dentate gyrus of hippocampal formation granule cell; ; skin of external ear;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; signal transducer activity; protein binding; cytokine binding;
Cellular component	integral component of membrane; membrane; extracellular region; extracellular space; external side of plasma membrane; receptor complex;
Biological process	negative regulation of mast cell degranulation; negative regulation of immunoglobulin production; immunoglobulin mediated immune response; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3598
	16165
	ENSG00000123496
	ENSMUSG00000031289
	Q14627
	O88786
	NM_000640
	NM_008356; NM_001306059
	NP_000631
	NP_001292988; NP_032382
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.^[5]

Function

IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however, able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.^[5]

Clinical Significance

IL-13Rα2 has been found to be over-expressed in a variety of cancers, including pancreatic, ovarian, melanomas, and malignant gliomas. ^[6]^[7]^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123496 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031289 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: IL13RA2 interleukin 13 receptor, alpha 2".
^ Fujisawa T, Joshi B, Nakajima A, Puri RK (November 2009). "A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis". Cancer Research. 69 (22): 8678–85. doi:10.1158/0008-5472.CAN-09-2100. PMID 19887609.
^ Kioi M, Kawakami M, Shimamura T, Husain SR, Puri RK (September 2006). "Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy". Cancer. 107 (6): 1407–18. doi:10.1002/cncr.22134. PMID 16902988. S2CID 70773746.
^ Okamoto H, Yoshimatsu Y, Tomizawa T, Kunita A, Takayama R, Morikawa T, Komura D, Takahashi K, Oshima T, Sato M, Komai M, Podyma-Inoue KA, Uchida H, Hamada H, Fujiu K, Ishikawa S, Fukayama M, Fukuhara T, Watabe T (February 2019). "Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma". Scientific Reports. 9 (1): 1281. Bibcode:2019NatSR...9.1281O. doi:10.1038/s41598-019-39018-3. PMC 6362032. PMID 30718742.
^ Joshi BH, Plautz GE, Puri RK (March 2000). "Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas". Cancer Research. 60 (5): 1168–72. PMID 10728667.

Andrews AL, Nasir T, Bucchieri F, Holloway JW, Holgate ST, Davies DE (October 2006). "IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts". The Journal of Allergy and Clinical Immunology. 118 (4): 858–65. doi:10.1016/j.jaci.2006.06.041. PMID 17030238.
Caput D, Laurent P, Kaghad M, Lelias JM, Lefort S, Vita N, Ferrara P (July 1996). "Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain". The Journal of Biological Chemistry. 271 (28): 16921–6. doi:10.1074/jbc.271.28.16921. PMID 8663118.
Zhang JG, Hilton DJ, Willson TA, McFarlane C, Roberts BA, Moritz RL, Simpson RJ, Alexander WS, Metcalf D, Nicola NA (April 1997). "Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains". The Journal of Biological Chemistry. 272 (14): 9474–80. doi:10.1074/jbc.272.14.9474. PMID 9083087.
Gauchat JF, Schlagenhauf E, Feng NP, Moser R, Yamage M, Jeannin P, Alouani S, Elson G, Notarangelo LD, Wells T, Eugster HP, Bonnefoy JY (April 1997). "A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor". European Journal of Immunology. 27 (4): 971–8. doi:10.1002/eji.1830270425. PMID 9130652. S2CID 23762963.
Guo J, Apiou F, Mellerin MP, Lebeau B, Jacques Y, Minvielle S (May 1997). "Chromosome mapping and expression of the human interleukin-13 receptor". Genomics. 42 (1): 141–5. doi:10.1006/geno.1997.4628. PMID 9177784.
Donaldson DD, Whitters MJ, Fitz LJ, Neben TY, Finnerty H, Henderson SL, O'Hara RM, Beier DR, Turner KJ, Wood CR, Collins M (September 1998). "The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1". Journal of Immunology. 161 (5): 2317–24. doi:10.4049/jimmunol.161.5.2317. PMID 9725226. S2CID 255357984.
Osawa M, Miyoshi S, Copeland NG, Gilbert DJ, Jenkins NA, Hiroyama T, Motohashi T, Nakamura Y, Iwama A, Nakauchi H (September 2000). "Characterization of the mouse interleukin-13 receptor alpha1 gene". Immunogenetics. 51 (11): 974–81. doi:10.1007/s002510000225. PMID 11003391. S2CID 9030454.
Kawakami K, Takeshita F, Puri RK (July 2001). "Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain". The Journal of Biological Chemistry. 276 (27): 25114–20. doi:10.1074/jbc.M100936200. PMID 11352909.
Daines MO, Hershey GK (March 2002). "A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma". The Journal of Biological Chemistry. 277 (12): 10387–93. doi:10.1074/jbc.M108109200. PMID 11786536.
Okano F, Storkus WJ, Chambers WH, Pollack IF, Okada H (September 2002). "Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain". Clinical Cancer Research. 8 (9): 2851–5. PMID 12231526.
Cancino-Díaz JC, Reyes-Maldonado E, Bañuelos-Pánuco CA, Jiménez-Zamudio L, García-Latorre E, León-Dorantes G, Blancas-González F, Paredes-Cabrera G, Cancino-Díaz ME (November 2002). "Interleukin-13 receptor in psoriatic keratinocytes: overexpression of the mRNA and underexpression of the protein". The Journal of Investigative Dermatology. 119 (5): 1114–20. doi:10.1046/j.1523-1747.2002.19509.x. PMID 12445201.
David M, Bertoglio J, Pierre J (November 2002). "TNF-alpha potentiates IL-4/IL-13-induced IL-13Ralpha2 expression". Annals of the New York Academy of Sciences. 973 (1): 207–9. Bibcode:2002NYASA.973..207D. doi:10.1111/j.1749-6632.2002.tb04633.x. PMID 12485861. S2CID 86154739.
Wu AH, Low WC (July 2003). "Molecular cloning and identification of the human interleukin 13 alpha 2 receptor (IL-13Ra2) promoter". Neuro-Oncology. 5 (3): 179–87. doi:10.1215/s1152851702000510. PMC 1920687. PMID 12816724.
Arima K, Sato K, Tanaka G, Kanaji S, Terada T, Honjo E, Kuroki R, Matsuo Y, Izuhara K (July 2005). "Characterization of the interaction between interleukin-13 and interleukin-13 receptors". The Journal of Biological Chemistry. 280 (26): 24915–22. doi:10.1074/jbc.M502571200. PMID 15870068.
Fichtner-Feigl S, Strober W, Kawakami K, Puri RK, Kitani A (January 2006). "IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis". Nature Medicine. 12 (1): 99–106. doi:10.1038/nm1332. PMID 16327802. S2CID 38397076.
Daines MO, Tabata Y, Walker BA, Chen W, Warrier MR, Basu S, Hershey GK (June 2006). "Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling". Journal of Immunology. 176 (12): 7495–501. doi:10.4049/jimmunol.176.12.7495. PMID 16751396.
Kioi M, Kawakami M, Shimamura T, Husain SR, Puri RK (September 2006). "Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy". Cancer. 107 (6): 1407–18. doi:10.1002/cncr.22134. PMID 16902988. S2CID 70773746.
Granel B, Allanore Y, Chevillard C, Arnaud V, Marquet S, Weiller PJ, Durand JM, Harlé JR, Grange C, Frances Y, Berbis P, Gaudart J, de Micco P, Kahan A, Dessein A (October 2006). "IL13RA2 gene polymorphisms are associated with systemic sclerosis". The Journal of Rheumatology. 33 (10): 2015–9. PMID 16981293.

External links

IL13RA2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: Q14627 (Interleukin-13 receptor subunit alpha-2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123496 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031289 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IL13RA2 interleukin 13 receptor, alpha 2".

[6] Fujisawa T, Joshi B, Nakajima A, Puri RK (November 2009). "A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis". Cancer Research. 69 (22): 8678–85. doi:10.1158/0008-5472.CAN-09-2100. PMID 19887609.

[7] Kioi M, Kawakami M, Shimamura T, Husain SR, Puri RK (September 2006). "Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy". Cancer. 107 (6): 1407–18. doi:10.1002/cncr.22134. PMID 16902988. S2CID 70773746.

[8] Okamoto H, Yoshimatsu Y, Tomizawa T, Kunita A, Takayama R, Morikawa T, Komura D, Takahashi K, Oshima T, Sato M, Komai M, Podyma-Inoue KA, Uchida H, Hamada H, Fujiu K, Ishikawa S, Fukayama M, Fukuhara T, Watabe T (February 2019). "Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma". Scientific Reports. 9 (1): 1281. Bibcode:2019NatSR...9.1281O. doi:10.1038/s41598-019-39018-3. PMC 6362032. PMID 30718742.

[9] Joshi BH, Plautz GE, Puri RK (March 2000). "Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas". Cancer Research. 60 (5): 1168–72. PMID 10728667.

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

IL13RA2

Function

Clinical Significance

See also

References

Further reading

External links