Zinc transporter 1

SLC30A1
Identifiers
Aliases	SLC30A1, ZNT1, ZRC1, solute carrier family 30 member 1
External IDs	OMIM: 609521; MGI: 1345281; HomoloGene: 6681; GeneCards: SLC30A1; OMA:SLC30A1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	211,579,161 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	191,645,359 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; caput epididymis; ; Epithelium of choroid plexus; ; skin of thigh; ; trabecular bone; ; dorsal motor nucleus of vagus nerve; ; vulva; ; cartilage tissue; ; corpus epididymis; ; human penis;
	Top expressed in
	placenta; ; lip; ; ileum; ; renal cortex; ; proximal tubule; ; human kidney; ; primary oocyte; ; hair; ; secondary oocyte; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium channel inhibitor activity; cation transmembrane transporter activity; protein binding; zinc ion transmembrane transporter activity;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; nuclear membrane; membrane; T-tubule; plasma membrane; endoplasmic reticulum; Schaffer collateral - CA1 synapse; integral component of postsynaptic density membrane;
Biological process	negative regulation of neurotransmitter secretion; calcium ion import; zinc ion transport; cellular calcium ion homeostasis; response to zinc ion; cation transport; in utero embryonic development; ion transport; negative regulation of calcium ion import; detoxification of cadmium ion; negative regulation of zinc ion transmembrane import; zinc ion transmembrane transport; cellular zinc ion homeostasis; cadmium ion transmembrane transport; regulation of sequestering of zinc ion; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	7779
	22782
	ENSG00000170385
	ENSMUSG00000037434
	Q9Y6M5
	Q60738
	NM_021194
	NM_009579
	NP_067017
	NP_033605
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene.^[5]^[6]

Function

SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn⁺⁺ influx, but also Ca⁺⁺ influx, thereby protecting cells from the effects of excessive cation permeation.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170385 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037434 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Palmiter RD, Findley SD (February 1995). "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc". The EMBO Journal. 14 (4): 639–49. doi:10.1002/j.1460-2075.1995.tb07042.x. PMC 398127. PMID 7882967.
^ Seve M, Chimienti F, Devergnas S, Favier A (May 2004). "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression". BMC Genomics. 5 (1): 32. doi:10.1186/1471-2164-5-32. PMC 428573. PMID 15154973.
^ Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I (October 2004). "A role for ZnT-1 in regulating cellular cation influx". Biochemical and Biophysical Research Communications. 323 (4): 1145–50. doi:10.1016/j.bbrc.2004.08.211. PMID 15451416.

Guey LT, GarcÃa-Closas M, Murta-Nascimento C, et al. (2009). "Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes". Eur. Urol. 57 (2): 283–292. doi:10.1016/j.eururo.2009.08.001. PMC 3220186. PMID 19692168.
Zhang LH, Wang X, Stoltenberg M, et al. (2008). "Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain". Brain Res. Bull. 77 (1): 55–60. doi:10.1016/j.brainresbull.2008.03.014. PMID 18639746. S2CID 33951242.
Lovell MA, Smith JL, Xiong S, Markesbery WR (2005). "Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease". Neurotoxicity Research. 7 (4): 265–71. doi:10.1007/BF03033884. PMID 16179263. S2CID 11433.
Zhang LY, Wang XL, Sun DX, et al. (2008). "Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts". Mol. Biol. Rep. 35 (4): 595–600. doi:10.1007/s11033-007-9129-8. PMID 17786585. S2CID 2490974.
Iguchi K, Otsuka T, Usui S, et al. (2004). "Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells". J. Androl. 25 (1): 154–61. doi:10.1002/j.1939-4640.2004.tb02771.x. PMID 14662799.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lazarczyk M, Pons C, Mendoza JA, et al. (2008). "Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses". J. Exp. Med. 205 (1): 35–42. doi:10.1084/jem.20071311. PMC 2234378. PMID 18158319.
Overbeck S, Uciechowski P, Ackland ML, et al. (2008). "Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9". J. Leukoc. Biol. 83 (2): 368–80. doi:10.1189/jlb.0307148. PMID 17971500. S2CID 21801798.
Hosgood HD, Menashe I, He X, et al. (2009). "PTEN identified as important risk factor of chronic obstructive pulmonary disease". Respiratory Medicine. 103 (12): 1866–1870. doi:10.1016/j.rmed.2009.06.016. PMC 2783799. PMID 19625176.
Hosgood HD, Menashe I, Shen M, et al. (2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway". Carcinogenesis. 29 (10): 1938–43. doi:10.1093/carcin/bgn178. PMC 2722857. PMID 18676680.
Etzion Y, Ganiel A, Beharier O, et al. (2008). "Correlation between atrial ZnT-1 expression and atrial fibrillation in humans: a pilot study". J. Cardiovasc. Electrophysiol. 19 (2): 157–64. doi:10.1111/j.1540-8167.2007.01008.x. PMID 17971132. S2CID 8430908.
Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170385 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037434 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7882967-5] Palmiter RD, Findley SD (February 1995). "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc". The EMBO Journal. 14 (4): 639–49. doi:10.1002/j.1460-2075.1995.tb07042.x. PMC 398127. PMID 7882967.

[pmid15154973-6] Seve M, Chimienti F, Devergnas S, Favier A (May 2004). "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression". BMC Genomics. 5 (1): 32. doi:10.1186/1471-2164-5-32. PMC 428573. PMID 15154973.

[pmid15451416-7] Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I (October 2004). "A role for ZnT-1 in regulating cellular cation influx". Biochemical and Biophysical Research Communications. 323 (4): 1145–50. doi:10.1016/j.bbrc.2004.08.211. PMID 15451416.

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Zinc transporter 1

Function

See also

References

Further reading