Sodium-coupled neutral amino acid transporter 2

SLC38A2
Identifiers
Aliases	SLC38A2, ATA2, PRO1068, SAT2, SNAT2, solute carrier family 38 member 2
External IDs	OMIM: 605180; MGI: 1915010; HomoloGene: 23132; GeneCards: SLC38A2; OMA:SLC38A2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	46,372,773 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	96,597,611 bp
RNA expression pattern
	Top expressed in
	tibia; ; visceral pleura; ; parietal pleura; ; gingival epithelium; ; skin of thigh; ; skin of hip; ; endothelial cell; ; lower lobe of lung; ; germinal epithelium; ; mucosa of paranasal sinus;
	Top expressed in
	epithelium of lens; ; endothelial cell of lymphatic vessel; ; medullary collecting duct; ; pineal gland; ; renal corpuscle; ; Paneth cell; ; hand; ; lacrimal gland; ; atrium; ; parotid gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; symporter activity; amino acid transmembrane transporter activity; L-glutamine transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; axon; soma; dendrite; brush border; sarcolemma;
Biological process	sodium ion transport; female pregnancy; cellular response to amino acid starvation; glutamate secretion; cellular response to mechanical stimulus; glycine betaine transport; cerebral cortex development; amino acid transport; alanine transport; ion transport; amino acid transmembrane transport; glutamine transport;
	Sources:Amigo / QuickGO
Orthologs
	54407
	67760
	ENSG00000134294
	ENSMUSG00000022462
	Q96QD8
	Q8CFE6
	NM_001307936; NM_018976
	NM_175121; NM_001355633
	NP_001294865; NP_061849; NP_061849.2
	NP_780330; NP_001342562
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium-coupled neutral amino acid transporter 2 is a protein that in humans is encoded by the SLC38A2 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134294 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022462 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sugawara M, Nakanishi T, Fei YJ, Huang W, Ganapathy ME, Leibach FH, Ganapathy V (Jul 2000). "Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A". J Biol Chem. 275 (22): 16473–7. doi:10.1074/jbc.C000205200. PMID 10747860.
^ Zhang Z, Grewer C (Mar 2007). "The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates". Biophys J. 92 (7): 2621–32. Bibcode:2007BpJ....92.2621Z. doi:10.1529/biophysj.106.100776. PMC 1864845. PMID 17237199.
^ "Entrez Gene: SLC38A2 solute carrier family 38, member 2".

Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Hatanaka T, Huang W, Wang H, et al. (2000). "Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A.". Biochim. Biophys. Acta. 1467 (1): 1–6. doi:10.1016/S0005-2736(00)00252-2. PMID 10930503.
Freeman TL, Thiele GM, Tuma DJ, et al. (2002). "ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane". Arch. Biochem. Biophys. 400 (2): 215–22. doi:10.1016/S0003-9861(02)00006-1. PMID 12054432.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Palii SS, Chen H, Kilberg MS (2004). "Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element". J. Biol. Chem. 279 (5): 3463–71. doi:10.1074/jbc.M310483200. PMID 14623874.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Franchi-Gazzola R, Gaccioli F, Bevilacqua E, et al. (2005). "The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system A transport activity". Biochim. Biophys. Acta. 1667 (2): 157–66. doi:10.1016/j.bbamem.2004.09.012. PMID 15581851.
Bevilacqua E, Bussolati O, Dall'Asta V, et al. (2005). "SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress". FEBS Lett. 579 (16): 3376–80. doi:10.1016/j.febslet.2005.05.002. PMID 15922329. S2CID 30690140.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Novak D, Quiggle F, Haafiz A (2006). "Impact of forskolin and amino acid depletion upon System A activity and SNAT expression in BeWo cells". Biochimie. 88 (1): 39–44. doi:10.1016/j.biochi.2005.07.002. PMID 16125834.
Palii SS, Thiaville MM, Pan YX, et al. (2006). "Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene". Biochem. J. 395 (3): 517–27. doi:10.1042/BJ20051867. PMC 1462688. PMID 16445384.
Melone M, Varoqui H, Erickson JD, Conti F (2006). "Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex". Neuroscience. 140 (1): 281–92. doi:10.1016/j.neuroscience.2006.02.042. PMID 16616430. S2CID 10542427.
Gaccioli F, Huang CC, Wang C, et al. (2006). "Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation". J. Biol. Chem. 281 (26): 17929–40. doi:10.1074/jbc.M600341200. PMID 16621798.
Jones HN, Ashworth CJ, Page KR, McArdle HJ (2006). "Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo)". Am. J. Physiol. Endocrinol. Metab. 291 (3): E596–603. doi:10.1152/ajpendo.00359.2005. PMID 16621896. S2CID 11068094.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134294 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022462 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10747860-5] Sugawara M, Nakanishi T, Fei YJ, Huang W, Ganapathy ME, Leibach FH, Ganapathy V (Jul 2000). "Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A". J Biol Chem. 275 (22): 16473–7. doi:10.1074/jbc.C000205200. PMID 10747860.

[pmid17237199-6] Zhang Z, Grewer C (Mar 2007). "The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates". Biophys J. 92 (7): 2621–32. Bibcode:2007BpJ....92.2621Z. doi:10.1529/biophysj.106.100776. PMC 1864845. PMID 17237199.

[entrez-7] "Entrez Gene: SLC38A2 solute carrier family 38, member 2".

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[2]

[3]

[4]

[5]

[6]

[7]

Sodium-coupled neutral amino acid transporter 2

See also

References

Further reading