SLC26A6

SLC26A6
Identifiers
Aliases	SLC26A6, solute carrier family 26 member 6
External IDs	OMIM: 610068; MGI: 2159728; HomoloGene: 99903; GeneCards: SLC26A6; OMA:SLC26A6 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 48,625,723 bp End 48,635,493 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F2 Start 108,730,482 bp End 108,742,117 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon Descending thoracic aorta popliteal artery tibial arteries ascending aorta oocyte rectum stromal cell of endometrium left coronary artery body of stomach Top expressed in duodenum jejunum ileum primary oocyte yolk sac pancreas muscle tissue skeletal muscle tissue quadriceps femoris muscle secondary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function PDZ domain binding formate transmembrane transporter activity chloride transmembrane transporter activity anion transmembrane transporter activity sulfate transmembrane transporter activity secondary active sulfate transmembrane transporter activity bicarbonate transmembrane transporter activity formate efflux transmembrane transporter activity oxalate transmembrane transporter activity protein binding efflux transmembrane transporter activity antiporter activity chloride channel activity inorganic anion exchanger activity Cellular component integral component of membrane membrane intracellular membrane-bounded organelle vesicle membrane plasma membrane integral component of plasma membrane chloride channel complex brush border membrane basolateral plasma membrane apical plasma membrane endoplasmic reticulum sperm midpiece cytoplasmic vesicle membrane cytoplasmic vesicle intracellular anatomical structure vesicle Biological process oxalic acid secretion mannitol transport oxalate transport formate transport intracellular pH elevation sulfate transport epithelial fluid transport angiotensin-activated signaling pathway regulation of membrane potential regulation of intracellular pH cellular response to fructose stimulus ion transport transepithelial chloride transport protein kinase C signaling anion transport transepithelial transport cellular response to interferon-gamma sperm capacitation intestinal absorption chloride transport positive regulation of dipeptide transmembrane transport cellular response to cAMP anion transmembrane transport sulfate transmembrane transport bicarbonate transport transmembrane transport chloride transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65010 171429 Ensembl ENSG00000225697 ENSMUSG00000023259 UniProt Q9BXS9 Q8CIW6 RefSeq (mRNA) NM_134426 NM_001040454 NM_001281732 NM_001281733 NM_022911 NM_134263 NM_134420 RefSeq (protein) NP_001035544 NP_001268661 NP_001268662 NP_075062 NP_599025 NP_602298 NP_001035544.1 NP_599252 NP_001395316 Location (UCSC) Chr 3: 48.63 – 48.64 Mb Chr 9: 108.73 – 108.74 Mb PubMed search
Wikidata
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Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.

Associated diseases

Diseases associated with SLC26A6 include sialolithiasis and urolithiasis.

See also

• Solute carrier family

Further reading

• Markovich D (2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiol. Rev. 81 (4): 1499–533. doi:10.1152/physrev.2001.81.4.1499. PMID 11581495. S2CID 30942862.
• Ignatovich O, Tomlinson IM, Popov AV, et al. (2000). "Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire". J. Mol. Biol. 294 (2): 457–65. doi:10.1006/jmbi.1999.3243. PMID 10610771.
• Xie Q, Welch R, Mercado A, et al. (2002). "Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1". Am. J. Physiol. Renal Physiol. 283 (4): F826–38. doi:10.1152/ajprenal.00079.2002. PMID 12217875.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chernova MN, Jiang L, Friedman DJ, et al. (2005). "Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity". J. Biol. Chem. 280 (9): 8564–80. doi:10.1074/jbc.M411703200. PMID 15548529.
• Kujala M, Tienari J, Lohi H, et al. (2006). "SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney". Nephron Exp. Nephrol. 101 (2): e50–8. doi:10.1159/000086345. PMID 15956810. S2CID 26671784.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Shcheynikov N, Wang Y, Park M, et al. (2006). "Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6". J. Gen. Physiol. 127 (5): 511–24. doi:10.1085/jgp.200509392. PMC 2151520. PMID 16606687.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Alper SL, Stewart AK, Chernova MN, et al. (2007). "Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides". Epithelial Anion Transport in Health and Disease: The Role of the SLC26 Transporters Family. Novartis Foundation Symposia. Vol. 273. pp. 107–19, discussion 119–25, 261–4. doi:10.1002/0470029579.ch8. ISBN 9780470016244. PMID 17120764.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.