TPM4

TPM4
Identifiers
Aliases	TPM4, HEL-S-108, tropomyosin 4
External IDs	OMIM: 600317; MGI: 2449202; HomoloGene: 100849; GeneCards: TPM4; OMA:TPM4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.12-p13.11 Start 16,067,021 bp End 16,103,002 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 B3.3 Start 72,884,018 bp End 72,906,986 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii stromal cell of endometrium right coronary artery gallbladder ascending aorta body of uterus left uterine tube smooth muscle tissue Descending thoracic aorta tibial arteries Top expressed in genital tubercle tail of embryo umbilical cord left lung lobe mandibular prominence maxillary prominence dermis endothelial cell of lymphatic vessel vas deferens abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding actin binding structural constituent of muscle protein binding metal ion binding identical protein binding protein homodimerization activity protein heterodimerization activity actin filament binding Cellular component cytoplasm filamentous actin podosome cytosol muscle thin filament tropomyosin cortical cytoskeleton extracellular exosome cytoskeleton membrane stress fiber focal adhesion actin filament actin cytoskeleton Biological process osteoblast differentiation muscle filament sliding muscle contraction actin filament organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7171 326618 Ensembl ENSG00000167460 ENSMUSG00000031799 UniProt P67936 Q6IRU2 RefSeq (mRNA) NM_001145160 NM_003290 NM_001367836 NM_001367837 NM_001367838 NM_001001491 RefSeq (protein) NP_001138632 NP_003281 NP_001354765 NP_001354766 NP_001354767 NP_001001491 Location (UCSC) Chr 19: 16.07 – 16.1 Mb Chr 8: 72.88 – 72.91 Mb PubMed search
Wikidata
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Tropomyosin alpha-4 chain is a protein that in humans is encoded by the TPM4 gene.

Further reading

• Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.
• MacLeod AR, Talbot K, Smillie LB, Houlker C (1987). "Characterization of a cDNA defining a gene family encoding TM30p1, a human fibroblast tropomyosin". J. Mol. Biol. 194 (1): 1–10. doi:10.1016/0022-2836(87)90710-8. PMID 3612796.
• MacLeod AR, Houlker C, Reinach FC, et al. (1986). "A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism". Proc. Natl. Acad. Sci. U.S.A. 82 (23): 7835–9. doi:10.1073/pnas.82.23.7835. PMC 390864. PMID 3865200.
• Lawrence B, Perez-Atayde A, Hibbard MK, et al. (2000). "TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors". Am. J. Pathol. 157 (2): 377–84. doi:10.1016/S0002-9440(10)64550-6. PMC 1850130. PMID 10934142.
• Meech SJ, McGavran L, Odom LF, et al. (2001). "Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4--anaplastic lymphoma kinase gene fusion". Blood. 98 (4): 1209–16. doi:10.1182/blood.V98.4.1209. PMID 11493472.
• Yi J, Kloeker S, Jensen CC, et al. (2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". J. Biol. Chem. 277 (11): 9580–9. doi:10.1074/jbc.M106922200. PMID 11782456.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884. PMID 15456888.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.